ChemicalBook
Chinese Japanese Germany Korea

tert-Butylchlorodiphenylsilane

tert-Butylchlorodiphenylsilane
tert-Butylchlorodiphenylsilane structure
CAS No.
58479-61-1
Chemical Name:
tert-Butylchlorodiphenylsilane
Synonyms
TBDP;TBDPCL;CB2805;TBDPSCI;TBDPSCl;CFS-611;Redistilled;orodiphenyL;SILANE TBP2;TBDPSCl FandaChem
CBNumber:
CB9302079
Molecular Formula:
C16H19ClSi
Formula Weight:
274.86
MOL File:
58479-61-1.mol

tert-Butylchlorodiphenylsilane Properties

Boiling point:
90 °C0.01 mm Hg(lit.)
Density 
1.057 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.568(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
miscible in most organic solvents.
form 
Liquid
Specific Gravity
1.074
color 
Clear colorless to yellow or slightly brown
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
BRN 
644023
CAS DataBase Reference
58479-61-1(CAS DataBase Reference)
FDA UNII
3BEU48UI4E
NIST Chemistry Reference
Silane, chloro(1,1-dimethylethyl)diphenyl-(58479-61-1)
EPA Substance Registry System
Silane, chloro(1,1-dimethylethyl)diphenyl- (58479-61-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H290-H314-H318
Precautionary statements  P280-P305+P351+P338-P310-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501-P303+P361+P353
Hazard Codes  C,Xi
Risk Statements  14-34-37-29-20/21/22-40
Safety Statements  26-36/37/39-45-8
RIDADR  UN 2987 8/PG 2
WGK Germany  3
10
Hazard Note  Irritant/Corrosive
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29310095

tert-Butylchlorodiphenylsilane price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 195537 tert-Butyl(chloro)diphenylsilane 98% 58479-61-1 2g $36.7 2021-12-16 Buy
Sigma-Aldrich 195537 tert-Butyl(chloro)diphenylsilane 98% 58479-61-1 1kg $1530 2021-12-16 Buy
TCI Chemical B1223 tert-Butyldiphenylchlorosilane >95.0%(GC) 58479-61-1 5mL $22 2021-12-16 Buy
TCI Chemical B1223 tert-Butyldiphenylchlorosilane >95.0%(GC) 58479-61-1 25mL $62 2021-12-16 Buy
Alfa Aesar A12721 tert-Butyldiphenylchlorosilane 97% 58479-61-1 10g $45.7 2021-12-16 Buy

tert-Butylchlorodiphenylsilane Chemical Properties,Uses,Production

Chemical Properties

Tert-Butylchlorodiphenylsilane is a colorless to pale brown oily liquid with pungent odor, may be used as silylating agent for derivatization of alcohols, ketones, carboxylic acids, amines, amides and mercaptanes selectively into functional groups in different sterical environments.

Physical properties

colorless liquid, bp 93–95°C/0.015 mmHg; n20 D 1.5680; d 1.057 g cm?3.

Uses

Several newmethods have been developed for using the reagent to protect primary and secondary alcohols as their TBDPS ethers. In the presence of ammonium nitrate or ammonium perchlorate, reaction between TBDPS-Cl and a primary alcohol, such as benzyl alcohol, in DMF provided excellent yields of the corresponding silyl ethers in just 15 min (eq 1).19 When silver nitrate was used as promoter, the reactions gave inferior yields under otherwise identical conditions.


When TBDPS-Cl is used to react with hemiacetals, it converts hemiacetals into ring-opened silyl ether carbonyl compounds, instead of mixed acetals.Presumably, the sizable TBDPS group presents too much steric hindrance for the formation of the corresponding mixed silyl acetals.

Uses

tert-Butyldiphenylchlorosilane acts as a silylating reagent used to protect alcohols and in the preparation of silyl ethers. It plays a major role as a raw material and a precursor in organic synthesis and pharmaceuticals. It is also used for the synthesis of interphenylene phenyloxazoles which can be used for the treatment of circulatory disorders, angina and stroke.

Preparation

a dry 1 L, three-necked round bottomed flask is equipped with a magnetic stirring bar, a 500mL equalizing dropping funnel fitted with a rubber septum, a reflux condenser, and nitrogen inlet tube. The flask is flushed with nitrogen, then charged with 127 g (0.5 mol) of diphenyldichlorosilane in 300mL of redistilled pentane. A solution of tbutyllithium in pentane (500 mL, 0.55 mol), is transferred under nitrogen pressure to the dropping funnel using a stainless steel, double-tip transfer needle. This solution is slowly added to the contents of the flask and when the addition is complete, the mixture is refluxed 30 h under nitrogen with stirring. The suspension is allowed to cool to rt, the precipitated lithium chloride is rapidly filtered through a pad of Celite, and the latter is washed with 200mL of pentane. The solvent is removed by evaporation, and the colorless residue is distilled through a short (10 cm), Vigreux column, to give 125–132 g of the colorless title compound.

Purification Methods

Purify it by repeated fractional distillaton. It is soluble in DMF and pentane [Hanessian & Lavalee Can J Chem 53 2975 1975, Robl et al. J Med Chem 34 2804 1991]. [Beilstein 4 IV 4076 for tert-butylchlorodimethylsilane.]

tert-Butylchlorodiphenylsilane Preparation Products And Raw materials

Raw materials

Preparation Products


tert-Butylchlorodiphenylsilane Suppliers

Global( 394)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
CD Chemical Group Limited
+8613651442114
0086-13651442114 info@codchem.com China 20383 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15427 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9128 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58

View Lastest Price from tert-Butylchlorodiphenylsilane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 tert-Butylchlorodiphenylsilane
58479-61-1
US $195.00 / T 1T 98% 1-10mt Baoji Guokang Bio-Technology Co., Ltd.
2021-08-25 tert-Butylchlorodiphenylsilane
58479-61-1
US $1.00 / KG 1KG 99 10T Henan Xiangtong Chemical Co., Ltd.
2021-07-09 tert-Butylchlorodiphenylsilane
58479-61-1
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

tert-Butylchlorodiphenylsilane Spectrum


58479-61-1(tert-Butylchlorodiphenylsilane)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved