ChemicalBook >> CAS DataBase List >>2-Bromo-4'-hydroxyacetophenone

2-Bromo-4'-hydroxyacetophenone

CAS No.
2491-38-5
Chemical Name:
2-Bromo-4'-hydroxyacetophenone
Synonyms
2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;Cyclohexane Impurity 5
CBNumber:
CB9306895
Molecular Formula:
C8H7BrO2
Molecular Weight:
215.04
MDL Number:
MFCD00072424
MOL File:
2491-38-5.mol
Last updated:2023-06-08 09:02:43

2-Bromo-4'-hydroxyacetophenone Properties

Melting point 123-126°C
Boiling point 338.7±17.0 °C(Predicted)
Density 1.622±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 7.69±0.15(Predicted)
form White powder
color White to Light Beige
Sensitive Lachrymatory
BRN 1865388
Stability Hygroscopic
Indirect Additives used in Food Contact Substances 2-BROMO-4'-HYDROXYACETOPHENONE
FDA 21 CFR 176.170; 176.300
CAS DataBase Reference 2491-38-5(CAS DataBase Reference)
FDA UNII 6H0QU4I6BA
EPA Substance Registry System 2-Bromo-4-hydroxyacetophenone (2491-38-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  C,Xn
Risk Statements  22-36
Safety Statements  26
RIDADR  1760
WGK Germany  1
RTECS  AM5982000
Hazard Note  Corrosive/Lachrymatory/Keep Cold
HazardClass  8
PackingGroup  III
HS Code  2914500090
NFPA 704
0
2 0

2-Bromo-4'-hydroxyacetophenone price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS013566 2-bromo-4′-hydroxyacetophenone AldrichCPR 2491-38-5 1G $81.6 2023-06-20 Buy
TCI Chemical B4115 2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T) 2491-38-5 5g $48 2024-03-01 Buy
TCI Chemical B4115 2-Bromo-4'-hydroxyacetophenone >98.0%(HPLC)(T) 2491-38-5 25g $151 2024-03-01 Buy
Cayman Chemical 19766 PTP Inhibitor I ≥98% 2491-38-5 5g $60 2023-06-20 Buy
Cayman Chemical 19766 PTP Inhibitor I ≥98% 2491-38-5 10g $112 2023-06-20 Buy
Product number Packaging Price Buy
CDS013566 1G $81.6 Buy
B4115 5g $48 Buy
B4115 25g $151 Buy
19766 5g $60 Buy
19766 10g $112 Buy

2-Bromo-4'-hydroxyacetophenone Chemical Properties,Uses,Production

Description

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.

Chemical Properties

Pale Beige Solid

Uses

A covalent inhibitor of protein tyrosine phosphatases (PTPs)

Preparation

Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.

in vitro

in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].

References

[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.

Global( 312)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2169 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81148696 +8615536356810 1047@dideu.com China 3984 58
Tangshan Moneide Trading Co., Ltd.
+86-315-8309571 +8615633399667 sales@moneidechem.com China 568 58

View Lastest Price from 2-Bromo-4'-hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-4'-hydroxyacetophenone pictures 2022-09-20 2-Bromo-4'-hydroxyacetophenone
2491-38-5
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Bromo-4'-hydroxyacetophenone       pictures 2020-06-30 2-Bromo-4'-hydroxyacetophenone
2491-38-5
US $2230.00 / KG 1KG 98.0% 1T Shaanxi Dideu Medichem Co. Ltd
2-Bromo-4'-hydroxyacetophenone pictures 2019-07-06 2-Bromo-4'-hydroxyacetophenone
2491-38-5
US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co

2-Bromo-4'-hydroxyacetophenone Spectrum

PTP INHIBITOR I PROTEIN TYROSINE PHOSPHATASE INHIBITOR I ALPHA-BROMO-4-HYDROXYACETOPHENONE 4-HYDROXYPHENACYL BR 4-HYDROXYPHENACYL BROMIDE 2-BROMO-1-(4-HYDROXY-PHENYL)-ETHANONE 2'-BROMO-4'-HYDROXYACETOPHENONE 2-BROMO-4'-HYDROXYACETOPHENONE 4-Hydroxy α-Bromoacetophenone 4-HYDROXY A-BROMOACETOPHENONE Ethanone, 2-bromo-1-(4-hydroxyphenyl)- A-BROMO-4-HYDROXY ACETOPHENONE 1-(4-hydroxyphenyl)-2-bromoethanone BROMOHYDROXYACETOPHENONE BUSAN1130 BUSAN90 2-Brom-1-(4-hydroxyphenyl)ethan-1-on α-Bromo-4-hydroxyacetophenone 4-Hydroxy-alpha-bromoacetophenone 2-Bromo-4-Hydroxyacetophenone98% Alpha broMine generation of hydroxy acetophenone α-broMo p-hydroxyacetophenone 4-(Bromoacetyl)phenol p-Hydroxy α-Bromoacetophenone 2-Bromo-4'-hydroxyacetophenone, 2-Bromo-1-(4-hydroxyphenyl)ethan-1-one Aipha-BroMo-4-hydroxyacetophenone Butrol 1130 p-Hydroxyphenacyl BroMide 4-Hydroxyphenacyl bromide 97% PTP Inhibitor I - CAS 2491-38-5 - Calbiochem 2-Bromo-4'-hydroxyacetophenone > SHP-1 Inhibitor II 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) BHAP 2-bromo-1-(4-hydroxyphenyl)ethan-1-one α-Bromo-4-hydroxyacetophenone Cyclohexane Impurity 5 2491-38-5 Aromatics Inhibitors Aromatic Acetophenones & Derivatives (substituted)