19-Norethindrone acetate
- CAS No.
- 51-98-9
- Chemical Name:
- 19-Norethindrone acetate
- Synonyms
- NORETHISTERONE ACETATE;NORETHINDRONE ACETATE;ENTA;Aygestin;sh420;17-Ent;SH 420;SH-420C;Orlutate;progylut
- CBNumber:
- CB9307049
- Molecular Formula:
- C22H28O3
- Molecular Weight:
- 340.46
- MDL Number:
- MFCD00271615
- MOL File:
- 51-98-9.mol
- MSDS File:
- SDS
| Melting point | 161-162° |
|---|---|
| Boiling point | 416.25°C (rough estimate) |
| Density | 1.1236 (rough estimate) |
| refractive index | -34 ° (C=1, Dioxane) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol. |
| color | Crystals from Me2CO/hexane |
| Water Solubility | 3.162mg/L(10 ºC) |
| Merck | 14,6697 |
| InChIKey | IMONTRJLAWHYGT-ZCPXKWAGSA-N |
| CAS DataBase Reference | 51-98-9(CAS DataBase Reference) |
| FDA UNII | 9S44LIC7OJ |
| Proposition 65 List | Norethisterone Acetate (Norethindrone Acetate) |
| NCI Drug Dictionary | Aygestin |
| NIST Chemistry Reference | Norethindrone acetate(51-98-9) |
19-Norethindrone acetate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R752029 | NORETHINDRONE ACETATE AldrichCPR | 51-98-9 | 50MG | $179 | 2024-03-01 | Buy |
| Sigma-Aldrich | R182265 | NORETHISTERONE ACETATE AldrichCPR | 51-98-9 | 1MG | $139 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR2534 | Norethindrone acetate Pharmaceutical Secondary Standard; Certified Reference Material | 51-98-9 | 200MG | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP267 | Norethisterone acetate British Pharmacopoeia (BP) Reference Standard | 51-98-9 | 100MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1470004 | Norethindrone acetate United States Pharmacopeia (USP) Reference Standard | 51-98-9 | 100mg | $436 | 2024-03-01 | Buy |
19-Norethindrone acetate Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Norlestrin,Parke Davis ,US,1964
Uses
Oral contraceptive (in combination with estrogen)
Uses
Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.
Definition
ChEBI: A 3-oxo Delta4-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.
Manufacturing Process
2.98 grams of 17-ethinyl-19-nor-testosterone (norethindrone) are suspended in 30 cc of acetic anhydride and a solution of 1.9 grams of p-toluenesulfonic acid in 19 cc of acetic anhydride is gradually added while cooling and stirring. Complete dissolution takes place after about one hour. After additional 30 to 60 minutes, a thick, pasty mass separates. The reaction is permitted to continue for a total period of 5 hours, whereupon water is added to the reaction mixture and the 3-enol-17-diacetate which separates after stirring for 1 to 2 hours is filtered off, washed until neutral and dried in vacuo over calcium chloride at room temperature.
In order to prepare the monoacetate, the crude diacetate is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetete, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C.
brand name
Aygestin (Duramed); Norlutate (Parke-Davis).
Therapeutic Function
Chemical Name: 19-Nor-17α-pregn-4-en-20-yn-3one, 17-hydroxy-, acetate
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Safety Profile
Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual dsorders and uterine bleedmg.
19-Norethindrone acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 269 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from 19-Norethindrone acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-01 | 19-Norethindrone acetate
51-98-9
|
US $0.00-0.00 / KG | 1KG | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2024-03-08 | 19-Norethindrone acetate
51-98-9
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd | |
 |
2023-11-27 | 19-Norethindrone acetate
51-98-9
|
US $0.00 / kg | 1kg | 99% min | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd |
-
- 19-Norethindrone acetate
51-98-9
- US $0.00-0.00 / KG
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- 19-Norethindrone acetate
51-98-9
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd
-
- 19-Norethindrone acetate
51-98-9
- US $0.00 / kg
- 99% min
- Wuhan Senwayer Century Chemical Co.,Ltd