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Siremadlin

Siremadlin structure

CAS No.: 1448867-41-1

Chemical Name:: Siremadlin

Synonyms: Siremadlin;HDM-201;CS-2787;CS-2613;NVP-HDM201;Siremadlin，HDM 201;NVP-HDM201 S-ISOMER;HDM201 (Siremadlin);Siremadlin (NVP-HDM201);HDM201 (Siremadlin) HCl

CBNumber:: CB93133461

Molecular Formula:: C26H24Cl2N6O4

Molecular Weight:: 555.41

MDL Number:: MFCD30502893

MOL File:: 1448867-41-1.mol

Last updated:2023-05-21 10:59:17

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Siremadlin Properties

Boiling point	736.5±70.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : ≥ 56.75 mg/mL (102.18 mM)
pka	1.33±0.29(Predicted)
FDA UNII	0282IF4JC8
NCI Drug Dictionary	siremadlin

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Siremadlin price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-7654	Siremadlin 99.82%	1448867-41-1	1mg	$70	2021-12-16	Buy
ChemScene	CS-7654	Siremadlin 99.82%	1448867-41-1	5mg	$150	2021-12-16	Buy
Biosynth Carbosynth	BH166424	NVP HDM 201	1448867-41-1	10mg	$175	2021-12-16	Buy
ChemScene	CS-7654	Siremadlin 99.82%	1448867-41-1	10mg	$220	2021-12-16	Buy
AK Scientific	1697DV	Siremadlin	1448867-41-1	10mg	$286	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-7654	1mg	$70	Buy
CS-7654	5mg	$150	Buy
BH166424	10mg	$175	Buy
CS-7654	10mg	$220	Buy
1697DV	10mg	$286	Buy

Siremadlin Chemical Properties,Uses,Production

Uses

Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies. the safety profile of Siremadlin did not differ significantly between tumor types and treatment regimens.

Siremadlin Preparation Products And Raw materials

Raw materials

Preparation Products

Siremadlin Suppliers

Global( 61)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3915	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
ShangHai ChuanQian Chemcial Technique Centre	58

View Lastest Price from Siremadlin manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-02	(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one 1448867-41-1	US $1.00-1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one
1448867-41-1
US $1.00-1.00 / KG
98%
Career Henan Chemical Co

Siremadlin Spectrum

Siremadlin(1448867-41-1)MS

1448867-41-1(Siremadlin)Related Search:

NVP-BAW2881 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride NVP-BSK805 NVP-BGT226 N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

TAE226 (NVP-TAE226) NVP-LCQ195 NVP-TAE684 NVP-BEZ 235

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(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)- Siremadlin (NVP-HDM201) NVP-HDM201 CS-2613 CS-2787 HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201 (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one NVP-HDM201;HDM-201;NVP-HDM-201 Siremadlin HDM-201 NVP-HDM201 S-ISOMER HDM201 (Siremadlin) HCl Siremadlin，HDM 201 HDM 201,E1/E2/E3 Enzyme,MDM-2/p53,E2 conjugating enzyme,HDM201,Inhibitor,HDM-201,Siremadlin,Ubiquitin activating enzyme,E3 ligating enzyme,inhibit,E1 activating enzyme,Ubiquitin ligase,NVP-HDM201,Ubiquitin conjugating enzyme NVP-HDM201(Siremadlin ) HDM201 (Siremadlin) NVP-HDM201 (SIREMADLIN) (HDM-201) 1448867-41-1 C26H24Cl2N6O4