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DISTAMYCIN A HYDROCHLORIDE

DISTAMYCIN A HYDROCHLORIDE structure

CAS No.: 6576-51-8

Chemical Name:: DISTAMYCIN A HYDROCHLORIDE

Synonyms: fi6426;herperal;MEN-10399;DISTAMYCIN A HCL;estalimicinaclorhidrato;stallimycinhydrochloride;DISTAMYCIN A HYDROCHLORIDE;distamycin A hydrochloride from*streptomyces dist;DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL;Distamycin A hydrochloride from Streptomyces distallicus

CBNumber:: CB9316227

Molecular Formula:: C22H28ClN9O4

Molecular Weight:: 517.97

MDL Number:: MFCD00058165

MOL File:: 6576-51-8.mol

Last updated:2023-05-04 15:15:38

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DISTAMYCIN A HYDROCHLORIDE Properties

Melting point	184-187° (Arcamone, 1967). Also reported as 189-193° from ethanol-ethyl acetate (Bialer)
storage temp.	−20°C
FDA UNII	F6010N240F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
WGK Germany	3
RTECS	WZ7110000
Toxicity	LD50 in mice (mg/kg): 75 i.v.; 500 i.p. (DiMarco)

DISTAMYCIN A HYDROCHLORIDE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0010151	DISTAMYCIN A HYDROCHLORIDE 95.00%	6576-51-8	5MG	$498.26	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0010151	5MG	$498.26	Buy

DISTAMYCIN A HYDROCHLORIDE Chemical Properties,Uses,Production

Originator

Herperal,Farmitalia,Italy,1978

Manufacturing Process

A spore suspension obtained upon washing a culture of Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following:Dextrose 2% Corn steep liquor extract 2% CaCO3 1% (NH4)2SO4 0.3% NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250 rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.
300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment is repeated twice. The butanolic extracts are combined, washed with water, evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution is carried out with the same solvent. The effluent (central fractions) is collected and evaporated to dryness to yield 0.43 g of pure distamycin A: decomposition point, 183°C to 185°C. The product can be further purified by crystallization from aqueous n-butanol.

Therapeutic Function

Antibiotic

DISTAMYCIN A HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

CORN STEEP LIQUOR D(+)-Glucose

Preparation Products

DISTAMYCIN A HYDROCHLORIDE Suppliers

Global( 20)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9503	50
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
Shaanxi Dideu Newmaterial Co., Ltd.	029-63373950 15353716720	1052@dideu.com	China	10007	58
Hubei Enxing Biotechnology Co., Ltd	16621771607	exbio_tech@163.com	China	8366	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
TopScience Biochemical	58
Alfa Chemistry	58
Chizhou Kailong Import and Export Trade Co., Ltd.	50
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	58
Shaanxi Dideu Newmaterial Co., Ltd.	58
Hubei Enxing Biotechnology Co., Ltd	58

6576-51-8(DISTAMYCIN A HYDROCHLORIDE)Related Search:

(1-METHYL-1H-PYRROL-2-YL)METHYLAMINE 1H-PYRROLE-2-CARBOXAMIDE Tallimustine Stallimycin 1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((2-(aminoiminomethy l)-1-methylethyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, d ihydrochloride

DISTAMYCIN A HYDROCHLORIDE METHYL-(1-METHYL-1H-PYRROL-2-YLMETHYL)-AMINE 1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-amino-3-iminopro pyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, dihydrochlorid e N-Methylpyrrole-2-carboxaldehyde propionamidine hydrochloride

1of2

1H-Pyrrole-2-carboxaMide,N-[5-[[(3-aMino-3-iMinopropyl)aMino]carbonyl]-1-Methyl-1H-pyrrol-3-yl]-4-[[[4-(forMylaMino)-1-Methyl-1H-pyrrol-2-yl]carbonyl]aMino]-1-Methyl-,hydrochloride (1:1) N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-me distamycin A hydrochloride from*streptomyces dist N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide monohydrochloride Distamycin A hydrochloride from Streptomyces distallicus MEN-10399 DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL estalimicinaclorhidrato fi6426 herperal stallimycinhydrochloride DISTAMYCIN A HCL DISTAMYCIN A HYDROCHLORIDE 6576-51-8 C22H27N9O4HCl C22H28O4N9Cl Antibiotics A to Z Antibiotics A-F Antibiotics BioChemical