TYRPHOSTIN B48
- CAS No.
- 133550-35-3
- Chemical Name:
- TYRPHOSTIN B48
- Synonyms
- 494;AG 494;CS-2755;TYRPHOSTIN B48;-494 Tyrphostin;TYRPHOSTIN AG 494;AG-494 Tyrphostin;TyrphostinAG494>AG-494;AG 494;AG494;AG 494 (Tyrphostin AG 494)
- CBNumber:
- CB9319132
- Molecular Formula:
- C16H12N2O3
- Molecular Weight:
- 280.28
- MDL Number:
- MFCD00209863
- MOL File:
- 133550-35-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| RIDADR | 3439 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2926.90.4801 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
TYRPHOSTIN B48 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2704 | Tyrphostin AG 494 >98.0%(HPLC)(N) | 133550-35-3 | 20mg | $91 | 2024-03-01 | Buy |
| TCI Chemical | A2704 | Tyrphostin AG 494 >98.0%(HPLC)(N) | 133550-35-3 | 100mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 10010242 | AG-494 ≥98% | 133550-35-3 | 5mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 10010242 | AG-494 ≥98% | 133550-35-3 | 10mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 10010242 | AG-494 ≥98% | 133550-35-3 | 25mg | $150 | 2024-03-01 | Buy |
TYRPHOSTIN B48 Chemical Properties,Uses,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).
References
[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.
TYRPHOSTIN B48 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24539 | 81 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
View Lastest Price from TYRPHOSTIN B48 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | TYRPHOSTIN B48
133550-35-3
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- TYRPHOSTIN B48
133550-35-3
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co