Alizarin Complexone
- CAS No.
- 3952-78-1
- Chemical Name:
- Alizarin Complexone
- Synonyms
- ALIZARIN COMPLEXON;ALIZARIN FLUORINE BLUE;ALC【Dotite】;nyl)methyl]-;cenyl)methyl)-;alizarinkomplexon;alizarinecomplexon;Alizarincompiexone;alizarinecomplexone;ALIZARIN COMPLEXONE
- CBNumber:
- CB9321290
- Molecular Formula:
- C19H15NO8
- Molecular Weight:
- 385.32
- MDL Number:
- MFCD00001202
- MOL File:
- 3952-78-1.mol
| Melting point | ~185 °C (dec.) |
|---|---|
| Boiling point | 511.79°C (rough estimate) |
| Density | 1.4951 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml |
| form | Fine Powder |
| pka | 1.71±0.10(Predicted) |
| color | Brown |
| Water Solubility | Slightly soluble (0.2 g/L) |
| BRN | 2190028 |
| Stability | Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C19H15NO8/c21-13(22)7-20(8-14(23)24)6-9-5-12-15(19(28)16(9)25)18(27)11-4-2-1-3-10(11)17(12)26/h1-5,25,28H,6-8H2,(H,21,22)(H,23,24) |
| InChIKey | PWIGYBONXWGOQE-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CN(CC(O)=O)CC1=C(O)C(O)=C2C(=C1)C(=O)C1=C(C=CC=C1)C2=O |
| CAS DataBase Reference | 3952-78-1(CAS DataBase Reference) |
| FDA UNII | TX8W05MTS6 |
| EPA Substance Registry System | Glycine, N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]- (3952-78-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AH0585000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29225090 | |||||||||
| NFPA 704 |
|
Alizarin Complexone price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A3882 | Alizarin-3-methyliminodiacetic acid | 3952-78-1 | 1g | $171 | 2024-03-01 | Buy |
| Sigma-Aldrich | A3882 | Alizarin-3-methyliminodiacetic acid | 3952-78-1 | 5g | $531 | 2024-03-01 | Buy |
| TCI Chemical | A3227 | Alizarin Complexone >70.0%(HPLC) | 3952-78-1 | 1g | $44 | 2024-03-01 | Buy |
| TCI Chemical | A3227 | Alizarin Complexone >70.0%(HPLC) | 3952-78-1 | 5g | $132 | 2024-03-01 | Buy |
| Alfa Aesar | A16699 | Alizarin Complexone, may cont. up to 10% water | 3952-78-1 | 1g | $94.6 | 2024-03-01 | Buy |
Alizarin Complexone Chemical Properties,Uses,Production
Description
Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions. It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae. It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).
Chemical Properties
Brown-orange crystals, insoluble in water
Uses
Alizarin Complexone is used for the determination of fluorine and other anions. ATA is also a potent inhibitor of protein-nucleic acid interactions.
Uses
Alizarin is the main ingredient for the manufacture of the madder lake pigments known to painters as Rose madder and Alizarin crimson. A notable use of alizarin in modern times is as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Alizarin Red is used in a biochemical assay to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage.
Uses
Alizarin-3-methyliminodiacetic acid has been used:
- for live staining of mineralized bone matrix
- to double-label the bone for dynamic bone histomorphometry at the femoral mid-diaphysis in the rat
- as a label in histomorphometry of the tibial diaphysis to indicate new bone formation in the rat
Definition
ChEBI: A dihydroxyanthraquinone compound in which the hydroxy groups are at C-1 and C-2 and which has a bis[(carboxymethyl)amino]methyl substituent at the 3-position.
General Description
Alizarin-3-methyliminodiacetic acid is used in the colorimetric detection of fluorine. It is a dye employed to stain mineralized bones of the preserved specimen from vertebrates.
Hazard
Anthraquinones are toxic by ingestion: vomiting, diarrhea, kidney and
liver damage, and coma;
Deaths have been reported after children
ingested Rhamnus berries;
Has antiretroviral activity;
An irritant;
Harmful by ingestion, inhalation, or skin
absorption;
Toxic if swallowed.
Purification Methods
It is purified by suspending it in 0.1M NaOH (1g in 50mL), filtering the solution and extracting alizarin with 5 successive portions of CH2Cl2. Then add HCl dropwise to precipitate the reagent, stirring the solution in an ice bath. Filter the precipitate onto a glass filter, wash it with cold water and dry it in a vacuum desiccator over KOH [Ingman Talanta 20 135 1973, Beilstein 14 IV 931].
Mode of action
Alizarin (1,2-dihydroxyanthraquinone) could form deeply colored metal complexes. Their stability can be increased considerably when edta-derived substituents are attached to the alizarin frame as a commercially available product of this type, alizarin complexone (AC) is a very useful reagent for the spectrophotometric determination of metals. The high stability of such metal complexes is essentially based on the chelate formation at the tridentate complexone substituent. However, if the coordination is restricted to this substituent, the spectral properties of alizarin should not be affected by metal cations owing to the electronically insulating methylene group between the complexone substituent and the alizarine nucleus. Accordingly, the color change observed upon complexation of AC is a consequence of forming an additional bond from a phenolate of the alizarin ring system to the metal[1]. Due to AC's low solubility in water, it could be soluble in ethanol in experiments. A solution of AC is yellow and displays an absorption with λmax = 430 nm(e = 5200 M-1 cm-1). The luminescence spectrum consists of two bands at λmax = 476 nm and 629 nm.
References
[1] Horst Kunkely, Arnd Vogler. “Fluorescence of alizarin complexone and its metal complexes.” Inorganic Chemistry Communications 10 3 (2007): Pages 355-357.
Alizarin Complexone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hongxiong | +undefined18915499068 | Suzhouhongxiong@163.com | China | 120 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
View Lastest Price from Alizarin Complexone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-08 | Alizarin Complexone
3952-78-1
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2023-09-08 | ALIZARIN COMPLEXONE
3952-78-1
|
US $100.00 / bag | 1bag | 99 | 5000 | Hebei Fengqiang Trading Co., LTD | |
 |
2023-05-04 | Alizarin Fluorine Blue/Alizarin-3-methyliminodiacetic acid
3952-78-1
|
US $48.00-40.00 / KG | 1KG | 99% | 200tons | Guangzhou Sunton Biotechnology Co., Ltd. |
-
- Alizarin Complexone
3952-78-1
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- ALIZARIN COMPLEXONE
3952-78-1
- US $100.00 / bag
- 99
- Hebei Fengqiang Trading Co., LTD
-
- Alizarin Fluorine Blue/Alizarin-3-methyliminodiacetic acid
3952-78-1
- US $48.00-40.00 / KG
- 99%
- Guangzhou Sunton Biotechnology Co., Ltd.