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Phenyl salicylate

Description References
Phenyl salicylate
Phenyl salicylate structure
CAS No.
118-55-8
Chemical Name:
Phenyl salicylate
Synonyms
SALOL;Musol;FEMA 3960;Salphenyl;Seesorb 201;'LGC' (2411);'LGC' (2613);Phenyl salicy;Seesorb K 201;AURORA KA-3673
CBNumber:
CB9322550
Molecular Formula:
C13H10O3
Formula Weight:
214.22
MOL File:
118-55-8.mol

Phenyl salicylate Properties

Melting point:
41-43 °C(lit.)
Boiling point:
172-173 °C12 mm Hg(lit.)
Density 
1.250g/cm3
refractive index 
1.5090 (estimate)
FEMA 
3960 | PHENYL SALICYLATE
Flash point:
>230 °F
storage temp. 
room temp
solubility 
dioxane: 0.1 g/mL, clear, colorless
form 
Fine Crystalline Powder
pka
8.71±0.10(Predicted)
color 
White
Water Solubility 
Soluble in alcohol, ether, chloroform, turpentine, acetone and benzene. Sparingly soluble in chloroformbenzene. Insoluble in water.
JECFA Number
736
Merck 
14,7310
BRN 
393969
Stability:
Light sensitive. Incompatible with strong oxidants. Flammable.
CAS DataBase Reference
118-55-8(CAS DataBase Reference)
FDA 21 CFR
177.1010; 310.545
Substances Added to Food (formerly EAFUS)
PHENYL SALICYLATE
EWG's Food Scores
1-3
FDA UNII
28A37T47QO
NIST Chemistry Reference
Benzoic acid, 2-hydroxy-, phenyl ester(118-55-8)
EPA Substance Registry System
Phenyl salicylate (118-55-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H303
Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
RIDADR  UN 3077 9 / PGIII
WGK Germany  2
RTECS  VO6125000
TSCA  Yes
HS Code  29182300
NFPA 704
1
2 0

Phenyl salicylate price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 149187 Phenyl salicylate ReagentPlus , 99% 118-55-8 50g $47.5 2020-08-18 Buy
Sigma-Aldrich 149187 Phenyl salicylate ReagentPlus , 99% 118-55-8 250g $52.9 2020-08-18 Buy
TCI Chemical S0017 Phenyl Salicylate >98.0%(GC) 118-55-8 25g $23 2020-06-24 Buy
TCI Chemical S0017 Phenyl Salicylate >98.0%(GC) 118-55-8 500g $85 2020-06-24 Buy
Alfa Aesar B20686 Phenyl salicylate, 99% 118-55-8 100g $25.2 2020-06-24 Buy

Phenyl salicylate Chemical Properties,Uses,Production

Description

Phenyl salicylate (chemical formula: C13H10O3) belongs to the family of hydroxybenzoic acid which are compound containing a hydroxybenzoic acid or its derivative. It is manufactured through the chemical reaction between phenol and salicylic acid. Phenyl salicylate has several medical properties. It can be used as analgesic to relieve pain, as an antiseptic with antibacterial effect as well as a kind of antipyretic for the treatment of fever. It is also used for the treatment of inflammation triggered by the lower urinary tract. However, it is no longer commonly applied to human medicine, but is still used in veterinary medicine.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Phenyl_salicylate#section=Top
http://www.wisegeek.com/what-are-the-medical-uses-of-phenyl-salicylate.htm

Chemical Properties

white crystalline solid with an aromatic odour

Chemical Properties

Phenyl salicylate has a distinctive aromatic odor and taste.

Occurrence

Has apparently not been reported to occur in nature.

Uses

Phenyl salicylate is used as an analgesic and antipyretic. It is also used in the manufacture of polymer plastics, lacquers, waxes, polishes, adhesives, and sunscreen products. It is also a fragrance ingredient, but has limited use.

Uses

In the manufacture of various polymers for the plastics industry, also in lacquers, adhesives, waxes, polishes. In suntan oils and cremes. As light absorber to prevent discoloration of plastics. Has some plasticizer properties.

Uses

Phenyl salicylate is used as analgesie; antipyretie; anti-rheumatie agent; manufacture of polymer plastics, lacquers, waxes, polishes, and adhesives; in suntan oils and creams; light absorber to prevent discoloration of plastics; in veterinary use as an external disinfectant and intestinal antiseptic agent.

Definition

ChEBI: A benzoate ester that is the phenyl ester of salicylic acid. Also known as salol, it can be formed by heating salicylic acid with phenol and is used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes.

Preparation

By the action of phosphorus oxychloride on a mixture of phenol and salicylic acid (Merck Index, 1968).

Toxicity evaluation

The acute oral LD50 value in rats was reported as 3 g/kg and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Levenstein, 1975). The probable LD in man is 50-500 mg/kg. The toxic effects of phenyl salicylate are similar to those of phenol but do not include a corrosive action on the alimentary canal (Dittmer, 1959).

General Description

White crystals. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Incompatible with bromine water, ferric salts, camphor, phenol, chloral hydrate, monobrominated camphor, thymol, or urethane in trituration. .

Fire Hazard

Flash point data for Phenyl salicylate are not available, however Phenyl salicylate is probably combustible.

Pharmacology

Phenyl salicylate was found to have slight analgesic activity against pain stimuli in mice (Kameyama, 1961), but ip administration of 500 mg/kg showed no analgesic action against an electric shock applied to the tails of mice (McKenzie & Beechey, 1962). In vitro studies on cartilage and rat-liver mitochondria have shown that phenyl salicylates are more active than salicylates in uncoupling oxidative phosphorylation (Bostrom, Berntsen & Whitehouse, 1964).

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS

Chemical Synthesis

Prepared by a synthetic process whereby the phenol group is made to unite with the salicylic acid radical. Also obtained by heating salicylic acid, the air being excluded.

Metabolism

According to Baas (1890) from 44 to 96% of a dose (5-8 g) of phenyl salicylate is hydrolysed in man and none of it is found in the faeces. An increase in the ethereal sulphates of the urine after its ingestion is due, no doubt, to the phenol liberated (Williams, 1959). Phenyl salicylate is hydrolysed in the gut primarily to phenol and salicylic acid, which are rapidly absorbed and excreted (Fassett, 1963), but it was not hydrolysed by a partially purified preparation of acetylarylesterase from human plasma (Augustinsson & Ekedahl, 1962). Intestinal absorption and excretion of orally administered phenyl salicylate were studied in rabbits and dogs by analysis of blood and urine samples; oral administration of glucosamine hydrochloride increased the blood concentration of phenyl salicylate but had little effect on urinary excretion (Tanaka, Kojima & Matsubara, 1961).

Purification Methods

Fractionally crystallise salol from its melt, then crystallise it from *benzene. [Beilstein 10 IV 154.]

Phenyl salicylate Preparation Products And Raw materials

Raw materials

Preparation Products


Phenyl salicylate Suppliers

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View Lastest Price from Phenyl salicylate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-09-18 PHENYL-O-HYDROXYBENZOATE
118-55-8
US $5.00 / g 1g 99.99% 20tons Xingtai pinmai biology science and technology co., ltd
2020-09-17 Disperse Dye Blue EXSF
118-55-8
US $10.00 / g 1g 99+% 50tons Xingtai pinmai biology science and technology co., ltd
2020-08-19 Phenyl salicylate
118-55-8
US $1.50 / g 1g 99% 50tons Xingtai pinmai biology science and technology co., ltd

Phenyl salicylate Spectrum


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