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Bestatin

Bestatin
Bestatin structure
CAS No.
58970-76-6
Chemical Name:
Bestatin
Synonyms
nk421;BENIMEX;UBENIMEX;BESTATIN;NSC 265489;Bestatin, >=99%;Ubenimex Ubenimex;Bestatin free base;UbeniMex(Bestatin);Bestatin, UbeniMex
CBNumber:
CB9324019
Molecular Formula:
C16H24N2O4
Formula Weight:
308.37
MOL File:
58970-76-6.mol

Bestatin Properties

Melting point:
245 °C (dec.)(lit.)
alpha 
D20 -15.5° (c = 1.0 in 1N HCl)
Boiling point:
448.76°C (rough estimate)
Density 
1.0917 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Powder
pka
8.1, 3.1(at 25℃)
color 
White
optical activity
[α]20/D 11°, c = 1 in 1 M NaOH
Water Solubility 
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.
Merck 
13,9910
InChIKey
VGGGPCQERPFHOB-RDBSUJKOSA-N
CAS DataBase Reference
58970-76-6(CAS DataBase Reference)
FDA UNII
I0J33N5627
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
RTECS  OH2915000
HS Code  29242998
Toxicity LD50 in male, female mice, male, female rats (g/kg): 1.3, 1.9, 1.9, 2.1 s.c.; 0.19, 0.19, 0.90, 0.78 i.p.; >4.0, >4.0, >2.0, >2.0 orally (Sakakibara)

Bestatin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 200484-M Bestatin - CAS 58970-76-6 - Calbiochem Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. 58970-76-6 10 mg $146.15 2021-03-22 Buy
Sigma-Aldrich 200484-M Bestatin 58970-76-6 10mg-m $158 2020-08-18 Buy
Sigma-Aldrich 10874515001 Bestatin [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride 58970-76-6 10 mg $230 2021-03-22 Buy
Sigma-Aldrich 482609 N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine 97% 58970-76-6 500mg $298 2021-03-22 Buy
TCI Chemical U0111 Ubenimex 58970-76-6 1G $395 2021-03-22 Buy

Bestatin Chemical Properties,Uses,Production

Description

Ubenimex is an immunostimulant useful in the treatment of non-lymphocytic leukemia. In other types of cancers ubenimex added to radiotherapy or chemotherapy following surgery significantly inmases survival time through immunopotentiation.

Chemical Properties

white powder

Originator

Inst. of Microbial Chem (Japan)

Uses

Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of all the cell lines except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were highly sensitive, with 50% growth inhibitory concentration

Uses

Bestatin is "pseudo"-dipeptide isolated from Strepotmyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits good antitumour activity and is has been investigated in clinical trials.

Uses

Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials.

brand name

Bestatin

Biological Activity

Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation.

Safety Profile

Poison by intraperitoneal route.Moderately toxic by subcutaneous route. Experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.

Bestatin Preparation Products And Raw materials

Raw materials

Preparation Products


Bestatin Suppliers

Global( 335)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chengdu Aslee Biopharmaceuticals, Inc.
+86 28 85305008
may.yang@asleechem.com CHINA 964 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58

View Lastest Price from Bestatin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Bestatin
58970-76-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 Bestatin
58970-76-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02 Ubenimex
58970-76-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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