ChemicalBook >> CAS DataBase List >>3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL

CAS No.
57717-80-3
Chemical Name:
3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
Synonyms
CGP 7930;3-(3',5'-DI-TERT-BUTYL-4'-HYDROXY)PHENYL-2,2-DIMETHYLPROPANOL;3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol;3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL;Benzenepropanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl-;3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol
CBNumber:
CB9331718
Molecular Formula:
C19H32O2
Molecular Weight:
292.46
MDL Number:
MFCD04040028
MOL File:
57717-80-3.mol
Last updated:2023-07-21 08:27:59

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Properties

storage temp. Desiccate at RT
solubility DMSO: 22 mg/mL, soluble
form solid
color white
FDA UNII ZAM4WWA5Y4

SAFETY

Risk and Safety Statements

WGK Germany  3

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29429 CGP 7930 57717-80-3 1mg $44 2024-03-01 Buy
Cayman Chemical 29429 CGP 7930 57717-80-3 5mg $130 2024-03-01 Buy
Cayman Chemical 29429 CGP 7930 57717-80-3 10mg $172 2024-03-01 Buy
Tocris 1513 CGP7930 ≥98%(HPLC) 57717-80-3 10 $159 2021-12-16 Buy
Tocris 1513 CGP7930 ≥98%(HPLC) 57717-80-3 50 $658 2021-12-16 Buy
Product number Packaging Price Buy
29429 1mg $44 Buy
29429 5mg $130 Buy
29429 10mg $172 Buy
1513 10 $159 Buy
1513 50 $658 Buy

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Chemical Properties,Uses,Production

Description

CGP 7930 is a positive allosteric modulator of GABAB receptors. It enhances GABA binding with a maximal effect of 143% compared to a GABA-only control in CHO cells membranes expressing the GABAB(1b/2) receptor and enhances GABA binding to rat cortical membranes when used at a concentration of 30 μM. It is selective for GABA binding to heterodimeric GABAB(1b/2) over monomeric GABAB(1b) receptors. CGP 7930 potentiates the efficacy of the GABAB receptor agonist baclofen in decreasing the spontaneous firing rate of dopaminergic neurons in the rat ventral tegmental area (VTA) in vitro (EC50 = 0.27 μM). It also potentiates the sedative-reducing effects induced by the GABAB receptor agonists baclofen and γ-hydroxybutyric acid (GHB) in rats when administered at doses ranging from 10 to 170 mg/kg, effects that can be blocked by the GABAB receptor antagonist SCH 50911. CGP 7930 reduces self-administration of nicotine, alcohol, and cocaine in rodent models. It suppresses the acquisition of alcohol drinking behavior in alcohol-naïve Sardinian alcohol-preferring rats over a five-day period when administered at doses ranging from 25 to 100 mg/kg and transiently reduces the maintenance of alcohol drinking behavior in alcohol-experienced rats at a dose of 100 mg/kg.

Definition

ChEBI: 2,6-ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol is an alkylbenzene.

Biological Activity

Positive allosteric modulator of GABA B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA B receptors (EC 50 values are 5.37 and 4.60 μ M respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.

storage

Desiccate at RT

128-39-2
57717-80-3
Synthesis of 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL from 2,6-Di-tert-butylphenol

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL Suppliers

Global( 37)Suppliers
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TargetMol Chemicals Inc.
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Shanghai Universal Biotech Co.,Ltd 18768175414 gaojun@univ-bio.com China 24998 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 3913 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 4141 58

57717-80-3(3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL)Related Search:

CGP 7930 3-(3',5'-DI-TERT-BUTYL-4'-HYDROXY)PHENYL-2,2-DIMETHYLPROPANOL 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL 3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol Benzenepropanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl- 57717-80-3 GABA/Glycine receptor