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Cysteamine hydrochloride

CAS No.
156-57-0
Chemical Name:
Cysteamine hydrochloride
Synonyms
CYSTEAMINE HCL;2-AMINOETHANETHIOL HYDROCHLORIDE;2-MERCAPTOETHYLAMINE HYDROCHLORIDE;Mercaptamine hydrochloride;mercaptoethylammonium chloride;2-Mercaptoethylammonium chloride;2-AMINOETHANE-1-THIOL HYDROCHLORIDE;2-AMINOETHANETHIOL HCL;Aminoethanethiol hydrochloride;DECARBOXYCYSTEINE HYDROCHLORIDE
CBNumber:
CB9337215
Molecular Formula:
C2H8ClNS
Molecular Weight:
113.61
MDL Number:
MFCD00012904
MOL File:
156-57-0.mol
MSDS File:
SDS
Last updated:2023-12-25 17:47:29

Cysteamine hydrochloride Properties

Melting point 67-71 °C
Boiling point 238.5℃[at 101 325 Pa]
Density 0.75
vapor pressure 5.333Pa at 25℃
refractive index 1.6100 (estimate)
storage temp. 2-8°C
solubility H2O: 1 m at 20 °C, clear, colorless
form Crystalline Powder or Pellets
color White
PH 3.3-5.0 (400g/l, H2O, 20℃)
Water Solubility VERY SOLUBLE
Sensitive Hygroscopic
λmax λ: 280 nm Amax: ≤0.3
Merck 14,2779
BRN 3590083
Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents.
InChIKey OGMADIBCHLQMIP-UHFFFAOYSA-N
LogP -2.14 at 25℃
CAS DataBase Reference 156-57-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII IF1B771SVB
EPA Substance Registry System Cysteamine hydrochloride (156-57-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317-H319-H335
Precautionary statements  P261-P264-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  36/37/39-26-36
RIDADR  UN 3335
WGK Germany  3
RTECS  KJ0200000
1-3-10-13
TSCA  Yes
HS Code  29309070
Toxicity LD50 orally in Rabbit: 642 mg/kg
NFPA 704
1
2 1

Cysteamine hydrochloride price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.02835 Cysteaminium chloride for synthesis 156-57-0 10g $44.5 2024-03-01 Buy
Sigma-Aldrich 8.02835 Cysteaminium chloride for synthesis 156-57-0 25g $55.1 2024-03-01 Buy
Sigma-Aldrich 8.02835 Cysteaminium chloride for synthesis 156-57-0 100g $148 2024-03-01 Buy
Sigma-Aldrich 30078 Cysteamine hydrochloride BioXtra 156-57-0 25g $139 2024-03-01 Buy
TCI Chemical A0296 2-Aminoethanethiol Hydrochloride >95.0%(T) 156-57-0 25g $40 2024-03-01 Buy
Product number Packaging Price Buy
8.02835 10g $44.5 Buy
8.02835 25g $55.1 Buy
8.02835 100g $148 Buy
30078 25g $139 Buy
A0296 25g $40 Buy

Cysteamine hydrochloride Chemical Properties,Uses,Production

Description

Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

Chemical Properties

White Solid

Uses

Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd2+ and S2-.

Uses

An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.

Uses

Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.

General Description

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.

Hazard

Toxic by inhalation and ingestion.

Biochem/physiol Actions

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles.

Synthesis

In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.

Purification Methods

Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]

870-24-6
156-57-0
Synthesis of Cysteamine hydrochloride from 2-Chloroethylamine hydrochloride
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View Lastest Price from Cysteamine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cysteamine hydrochloride pictures 2024-03-19 Cysteamine hydrochloride
156-57-0
US $20.00-1.00 / kg 1kg 99% 600tona Hebei Dangtong Import and export Co LTD
Cysteamine hydrochloride pictures 2024-03-19 Cysteamine hydrochloride
156-57-0
US $15.00-5.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD
Cysteamine hydrochloride pictures 2024-03-19 Cysteamine hydrochloride
156-57-0
US $80.00-70.00 / kg 1kg 99% 20Tons Hebei Dangtong Import and export Co LTD
DECARBOXYCYSTEINE HCL CYSTEAMINIUM CHLORIDE CYSTEAMINE HYDROCHLORIDE BETA-MERCAPTOETHYLAMINE HYDROCHLORIDE B-MERCAPTOETHYLAMINE HYDROCHLORIDE 2-AMINOETHYL MERCAPTAN HYDROCHLORIDE 2-AMINOETHANOTHIOL HYDROCHLORIDE 2-MERCAPTOETHYLAMINE HCL 2-amino-ethanethiohydrochloride 2-Aminoethylmercaptarhydrochloride 2-mercapto-ethylaminhydrochloride bekaptan THIOETHANOLAMINE HYDROCHLORIDE L-Cysteine HCL anhydrouse Aminoethanethiol hydrochloride~Cysteamine hydrochloride L-Cysteamine hydrochloride 2-MERCAPTOETHYLAMINE HYDROCHLORIDE, PRIMARY STANDARD 2-MERCAPTOETHYLAMINE HYDROCHLORIDE 98+% 2-MercaptoethylamineHydrochloride,~97% 1-Aminoethanethiol hydrochloride CYSTEAMINE HCL (2-AMINO ETHANE THIOL) TheFinePurification Cysteamine Hydrochloride 2-Aminoethanethiol hydrochloride ( cysteamine hydrochloride) Cysteamine hydrichloride (2-Mercaptoethylamine hydrochloride) CYSTEAMINE HCL 95% IN 75% SOLUTION 2-Aminoethanethiol h Cysteamine hydrochloride 99% CysteaMine hydrochloride / 2-AMinoethanothiol hydrochloride Cysteamine hydrochloride, 2-Mercaptoethylamine hydrochloride 2-Aminoethanethiol HCI 2-AMinoethanethiol hydrochloride, 98% 25GR 2-AMinoethanethiol hydrochloride, 98% 5GR 2-AMino­ ethane­ thiol hydrochloride CYSTEAMINIUM CHLORIDE FOR SYNTHESIS Ethanethiol, 2-aMino-, hydrochloride (1:1) H-Cys-NH2·HCl Cysteamine hydrochloride Vetec(TM) reagent grade, 98% Cysteamine hydrochloride, >=99% FREE SAMPLE NCV CYSTEAMINE HYDROCHLORIDE 2-Aminoethanethiol hydrochloride Cysteamine HCl β-Mercapto­ amine hydrochloride Cysteamine hydrochloride 2-Aminoethane-1-thiol hydrochloride 2-M cysteine hydrochloride Thio­ 2-MERCAPTOETHYLAMINE HYDROCHLORIDE +99% 2-MERCAPTOETHYLAMINE HYDROCHLORIDE 99+% PHARM GRADE CYSTEAMINE HCL 99% IN 75% SOLUTION CYSTEAMINE HCL POWDER CYSTEAMINE HCL SOLID beta-mercaptoaethylaminchlorhydrat cysteaminhydrochlorid Ethanethiol,2-amino-,hydrochloride mercaptoethylaminehydrochloride usafee-3 CYSTEAMINEHYDROCHLORIDEWATERSOLUTION 1-Amino-2-mercaptoethane hydrochloride 2-Mercaptoethanamine hydrochloride 2-Thioethylamine hydrochloride