Dextran Sulfate Sodium Salt

Dextran Sulfate Sodium Salt price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	265152-M	Dextran Sulfate, Sodium Salt, Molecular Biology Grade	9011-18-1	10gm-m	$62.5	2017-11-08	Buy
Sigma-Aldrich	265152-M	Dextran Sulfate, Sodium Salt, Molecular Biology Grade	9011-18-1	50gm-m	$205	2017-11-08	Buy
Alfa Aesar	J14489	Dextran sulfate sodium salt, Affymetrix/USB	9011-18-1	10g	$152	2017-11-08	Buy
Alfa Aesar	J14489	Dextran sulfate sodium salt, Affymetrix/USB	9011-18-1	50g	$463	2017-11-08	Buy
Sigma-Aldrich	51227	Dextran sulfate sodium salt		25g	$466.5	2017-11-08	Buy

Dextran Sulfate Sodium Salt Chemical Properties,Uses,Production

Description

Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.

• Enzyme inhibition, activation and release
• Adjuvant effect on immune response
• Cellular interactions and response
• Effect on virus infectivity

Uses

1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

Toxicity

The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

Chemical Properties

White to off-white powder

Uses

Clinical reagent (HDL cholesterol determination).

Dextran Sulfate Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

Dextran Sulfate Sodium Salt Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
Herbon International Holdings Company Limited	(+86) 0762 3499803	(+86) 0762 3499555	info@herbon-international.com	CHINA	3	55
Henan DaKen Chemical CO.,LTD.	+86-371-55531817		inquiry@dakenchem.com	CHINA	22144	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	0371-55170693	info@tianfuchem.com	CHINA	20803	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038		zheyansh@163.com	CHINA	3625	58
Beijing NuoqiYa Biotechnology Co., Ltd.	4000-819-385 010-62329685 13718666987	010-62340519	good@nuoqiya.com	China	1978	55
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-85201366 18018719207	0755-85201366	sales@regentsciences.com	China	3291	58
Herbon International Polysaccharide Biotechnology (Heyuan) Co. Ltd.	0762 3499803;18027990213	-	2141594860@qq.com	China	4	68
Beijing OKA biological technology co., LTD	010-62971590; 62971690; 13718666987	010-62971690	1534154405@qq.com	China	5359	58
Hubei XinghengKang Chemical Technology Co., Ltd.	027-88878869 18162384755	027-88878869	xhkhu2014@163.com	China	276	58
J & K SCIENTIFIC LTD.	400-666-7788 +86-10-82848833	+86-10-82849933	jkinfo@jkchemical.com;market6@jkchemical.com	China	96815	76

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