OTIORHLXOLCOAV-UHFFFAOYSA-N
- CAS No.
- 51938-11-5
- Chemical Name:
- OTIORHLXOLCOAV-UHFFFAOYSA-N
- Synonyms
- OTIORHLXOLCOAV-UHFFFAOYSA-N;Chlorpromazine 7-Hydroxy Impurity;7-Hydroxy-chlorpromazine hydrochloride salt;10H-Phenothiazin-3-ol, 8-chloro-10-[3-(dimethylamino)propyl]-,monohydrochloride
- CBNumber:
- CB93415259
- Molecular Formula:
- C17H20Cl2N2OS
- Molecular Weight:
- 371.32
- MDL Number:
- MOL File:
- 51938-11-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H330 | |||||||||
| Precautionary statements | P260-P264-P270-P271-P284-P301+P310-P330-P304+P340-P320-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
OTIORHLXOLCOAV-UHFFFAOYSA-N Chemical Properties,Uses,Production
Uses
7-Hydroxychlorpromazine is the 7-hydroxy analogue and a major metabolite of the atypical antipsychotic Chlorpromazine (C424750).
Biological Activity
7-hydroxy Chlorpromazine is an active metabolite of the typical antipsychotic chlorpromazine .1 In vivo, 7-hydroxy chlorpromazine (5 mg/kg) increases plasma prolactin levels in male rats. It also reverses D-amphetamine-induced depression of the dopaminergic neuronal firing rate in the rat substantia nigra in rats when administered at a dose of 1.6 mg/kg.2
References
1.Meltzer, H.Y., Fang, V.S., Simonovich, M., et al.Effect of metabolites of chlorpromazine on plasma prolactin levels in male ratsEur. J. Pharmacol.41(4)431-436(1977) 2.Bunney, B.S., and Aghajanian, G.K.A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neuronsLife Sci.15(2)309-318(1974)
OTIORHLXOLCOAV-UHFFFAOYSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
OTIORHLXOLCOAV-UHFFFAOYSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shenzhen Botel Biotechnology Co. Ltd. | 0755-22202135 13316968096 | 1979313431@qq.com | China | 8065 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Shanghai YuZn Pharm. Technology Co.,Ltd. | 15921286451; 15921286451 | 2010681527@qq.com | China | 5063 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |