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3-Fluoro-4-broMoaniline

3-Fluoro-4-broMoaniline structure

CAS No.: 656-65-5

Chemical Name:: 3-Fluoro-4-broMoaniline

Synonyms: 4-Bromo-3-fluoroanil;3-Fluoro-4-broMoanilin;4-BROMO-3-FLUOROANILINE;4-Bromo-3-fluoroaniline98%;4-Bromo-3-fluorobenzenamine;4-BROMO-3-FLUOROPHENYLAMINE;4-Bromo-3-fluoroaniline >4-BroMo-3-fluoroaniline, 97+%;Benzenamine, 4-bromo-3-fluoro-;4 - broMine - 3 - fluoro aniline

CBNumber:: CB9345779

Molecular Formula:: C6H5BrFN

Molecular Weight:: 190.01

MDL Number:: MFCD00672933

MOL File:: 656-65-5.mol

MSDS File:: SDS

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
4-Bromo-3-fluoroaniline 97%	518719	5g	$31.2
4-Bromo-3-fluoroaniline >98.0%(GC)	B2102	1g	$24
4-Bromo-3-fluoroaniline >98.0%(GC)	B2102	5g	$65
4-Bromo-3-fluoroaniline	B684550	25g	$80
4-BROMO-3-FLUOROANILINE 95.00%	HCH0023078	5G	$780.78
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3-Fluoro-4-broMoaniline Properties

Melting point	72-73°C
Boiling point	65-68 °C (lit.)
Density	0.982 g/mL at 25 °C (lit.)
refractive index	n20/D 1.471(lit.)
Flash point	105 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Acetonitrile, Methanol
form	Crystalline Powder
pka	2.88±0.10(Predicted)
color	Yellow to tan
Water Solubility	Soluble in acetonitrile, methanol. Insoluble in water.
BRN	3236457
InChI	InChI=1S/C6H5BrFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
InChIKey	YTMVYYAKOPIJCZ-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(Br)C(F)=C1
CAS DataBase Reference	656-65-5(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Xi,T,Xn

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN2811

WGK Germany

Hazard Note

Toxic

HazardClass

6.1

PackingGroup

III

HS Code

29214200

NFPA 704

	1
2		0

3-Fluoro-4-broMoaniline price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	518719	4-Bromo-3-fluoroaniline 97%	656-65-5	5g	$31.2	2025-07-31	Buy
TCI Chemical	B2102	4-Bromo-3-fluoroaniline >98.0%(GC)	656-65-5	1g	$24	2025-07-31	Buy
TCI Chemical	B2102	4-Bromo-3-fluoroaniline >98.0%(GC)	656-65-5	5g	$65	2025-07-31	Buy
TRC	B684550	4-Bromo-3-fluoroaniline	656-65-5	25g	$80	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0023078	4-BROMO-3-FLUOROANILINE 95.00%	656-65-5	5G	$780.78	2021-12-16	Buy

Product number	Packaging	Price	Buy
518719	5g	$31.2	Buy
B2102	1g	$24	Buy
B2102	5g	$65	Buy
B684550	25g	$80	Buy
HCH0023078	5G	$780.78	Buy

3-Fluoro-4-broMoaniline Chemical Properties,Uses,Production

Chemical Properties

Beige to brown needles and crystalline powder

Uses

4-Bromo-3-fluoroaniline is a intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4 ,4"-alkoxyalkylterphenyls.

Uses

4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.

Synthesis

351-30-4

656-65-5

General procedure for the synthesis of 4-bromo-3-fluoroaniline from 3-fluoro-4-bromoacetanilide: N-(4-bromo-3-fluorophenyl)acetamide (12.9 g, 12.9 mmol) was dissolved in ethanol (30 mL), and stirred until completely dissolved. Subsequently, concentrated hydrochloric acid (15 mL) was added to the solution and the reaction was refluxed at 80 °C for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with ice water and extracted with ethyl acetate. The organic layers were combined and washed sequentially with water and brine solution. Finally, the solvent was removed by vacuum distillation to afford 4-bromo-3-fluoroaniline (2.45 g, 100.0% yield) as an off-white solid.

References

[1] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 97; 98
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 43 - 64
[3] Journal of the Chemical Society, 1958, p. 2815,2818

3-Fluoro-4-broMoaniline Preparation Products And Raw materials

Raw materials

4'-Bromo-3'-fluoroacetanilide Ethanol Hydrochloric acid Water

Preparation Products

2-Bromo-5-fluoroaniline 4-Bromo-3-fluorophenol 4-Bromo-2-fluoro-1-(methylsulfonyl)benzene 6-Bromo-7-fluoroquinoline 4-AMINO-2-FLUOROBENZONITRILE

Methyl N-(4-bromo-3-fluorophenyl)carbamate 4-Bromo-5-fluoro-2-[(trimethylsilyl)ethynyl]aniline ethyl 3-(4-amino-2-fluorophenyl)propanoate

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3-Fluoro-4-broMoaniline Suppliers

Global( 395)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20171	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	299	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Bojing Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Changzhou Ansciep Chemical Co., Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 3-Fluoro-4-broMoaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	4-Bromo-3-fluoroaniline 656-65-5	US $8.00-0.80 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-08	4-Bromo-3-fluoroaniline 656-65-5	US $0.00 / KG Ton	1KG Ton	98%+	2 tons/month	Zhuhai Hairuide Bioscience and Technology Co., Ltd
2023-03-14	4-Bromo-3-fluoroaniline 656-65-5	US $0.00-0.00 / kg	1kg	98%Min	1000kg	LY Global chemicals co.,ltd .

4-Bromo-3-fluoroaniline
656-65-5
US $8.00-0.80 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Bromo-3-fluoroaniline
656-65-5
US $0.00 / KG Ton
98%+
Zhuhai Hairuide Bioscience and Technology Co., Ltd

4-Bromo-3-fluoroaniline
656-65-5
US $0.00-0.00 / kg
98%Min
LY Global chemicals co.,ltd .

3-Fluoro-4-broMoaniline Spectrum

3-Fluoro-4-broMoaniline(656-65-5)MS 3-Fluoro-4-broMoaniline(656-65-5)¹HNMR

656-65-5(3-Fluoro-4-broMoaniline)Related Search:

4-(Trifluoromethoxy)aniline 4-Fluoroaniline 2-Bromoaniline 2,4,5-Trifluoroaniline Ethyl bromodifluoroacetate

3-Fluoroaniline 2-Fluoroaniline 4-Bromoaniline Torezolid bis(((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl) hydrogen phosphate

Tedizolid Impurity 36 (S)-(+)-Glycidyl butyrate Tedizolid Impurity 39 (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl) phenyl)-2-oxooxazolidin-5-yl)methyl butyrate (R)-Glycidyl butyrate

(R)-3-(4-(6-(1H-tetrazol-5-yl)pyridin-3-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one Tedizolid phosphate impurity 5-Bromo-2-pyridinecarbonitrile

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4-BROMO-3-FLUOROPHENYLAMINE 4-BROMO-3-FLUOROANILINE 4-Bromo-3-fluoroaniline98% 4-Bromo-3-fluorobenzenamine 4-Bromo-3-fluoroanil 4-BroMo-3-fluoroaniline, 98% 5GR 4-BroMo-3-fluoroaniline, 97+% 4 - broMine - 3 - fluoro aniline 4-Bromo-3-fluoroaniline > Benzenamine, 4-bromo-3-fluoro- 4-Bromo-3-fluoroaniline ISO 9001：2015 REACH 4-Bromo-3-fluoroaniline 656-65-5 3-Fluoro-4-broMoanilin 656-65-5 BrC6H3FNH2 C6H5BrNF Nitrogen Compounds Organic Building Blocks Amines Building Blocks C2 to C6 Aryl Fluorinated Building Blocks Building Blocks Chemical Synthesis Fluorinated Building Blocks Nitrogen Compounds Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Amines blocks Bromides FluoroCompounds Fluorobenzene Anilines, Aromatic Amines and Nitro Compounds Aniline Anilines, Amides & Amines Bromine Compounds Fluorine Compounds Phenyls & Phenyl-Het C2 to C6 Nitrogen Compounds bc0001 C6