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Diclofenac potassium

Description References
Diclofenac potassium
Diclofenac potassium structure
CAS No.
15307-81-0
Chemical Name:
Diclofenac potassium
Synonyms
Keflan;ProSorb;K-fenak;Cataflam;Voltfast;CGP-45840B;Unii-L4D5ua6cb4;PotassiuM diclofenac;Diclofenic potassiuM;DICLOFENAC POTASSIUM
CBNumber:
CB9348932
Molecular Formula:
C14H10Cl2KNO2
Formula Weight:
334.24
MOL File:
15307-81-0.mol

Diclofenac potassium Properties

Melting point:
300-330 °C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
form 
neat
CAS DataBase Reference
15307-81-0(CAS DataBase Reference)
FDA UNII
L4D5UA6CB4
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H411
Precautionary statements  P301+P312+P330-P273
Hazard Codes  Xn,N
Risk Statements  22-51/53
Safety Statements  61
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2922492050

Diclofenac potassium price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1039990 Diclofenac potassium European Pharmacopoeia (EP) Reference Standard 15307-81-0 d1039990 $190 2020-08-18 Buy
Sigma-Aldrich D1039990 Diclofenac potassium European Pharmacopoeia (EP) Reference Standard 15307-81-0 $190 2021-03-22 Buy
Sigma-Aldrich PHR2441 Diclofenac potassium Pharmaceutical Secondary Standard; Certified Reference Material 15307-81-0 500MG $229 2021-03-22 Buy
Sigma-Aldrich 1188709 Diclofenac potassium 15307-81-0 200mg $366 2021-03-22 Buy

Diclofenac potassium Chemical Properties,Uses,Production

Description

Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.

References

Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.

Chemical Properties

White or slightly yellowish, slightly hygroscopic, crystalline powder.

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

Definition

ChEBI: The potassium salt of diclofenac.

brand name

Cataflam (Novartis).

Diclofenac potassium Preparation Products And Raw materials

Raw materials

Preparation Products


Diclofenac potassium Suppliers

Global( 277)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Hebei Zhuangkai Biotechnology Co.,Ltd.
+8618033787409
0311-89850048 zhuangkai@zk-chem.com China 299 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5508 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58

View Lastest Price from Diclofenac potassium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-27 Diclofenac potassium
15307-81-0
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-21 Diclofenac potassium
15307-81-0
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-10-20 Diclofenac potassium
15307-81-0
US $10.00 / KG 100g 99% 2000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

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