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1,4-Benzoquinone structure
Chemical Name:
pbq2;Chinon;QUINONE;CHINONE;p-Chinon;stearapbq;P-QUINONE;usafp-220;NSC 36324;Steara PBQ
Molecular Formula:
Formula Weight:
MOL File:

1,4-Benzoquinone Properties

Melting point:
113-115 °C(lit.)
Boiling point:
vapor density 
3.73 (vs air)
vapor pressure 
0.1 mm Hg ( 25 °C)
refractive index 
n20/D 1.453
Flash point:
storage temp. 
room temp
Yellow to green
4 (1g/l, H2O, 20℃)
Water Solubility 
10 g/L (25 ºC)
Exposure limits
TLV-TWA 0.4 mg/m3 (0.1 ppm); STEL 1.2 mg/m3 (0.3 ppm) (ACGIH); IDLH 75 ppm (NIOSH).
Stable, but light sensitive. Incompatible with strong oxidizing agents. Flammable.
CAS DataBase Reference
106-51-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
3 (Vol. 15, Sup 7, 71) 1999
NIST Chemistry Reference
EPA Substance Registry System
Quinone (106-51-4)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H371-H301+H331-H315-H319-H335-H410-H301-H331-H400
Precautionary statements  P260-P264-P270-P271-P280-P302+P352+P332+P313+P362+P364-P304+P340+P311-P305+P351+P338+P337+P313-P308+P311-P391-P405-P280a-P301+P310a-P501a-P261-P304+P340+P312-P305+P351+P338-P403+P233-P273-P301+P310+P330-P501
Hazard Codes  T,N,Xn,F
Risk Statements  23/25-36/37/38-50-20/21/22-11
Safety Statements  26-28-45-61-28A-23-16
RIDADR  UN 2587 6.1/PG 2
WGK Germany  3
RTECS  DK2625000
Autoignition Temperature 815 °F
HS Code  2914 69 80
HazardClass  6.1
PackingGroup  II
Toxicity LD50 orally in rats: 130 mg/kg (Woodard)
NFPA 704
3 0

1,4-Benzoquinone price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.02410 p-Benzoquinone for synthesis 106-51-4 100 g $28.58 2021-03-22 Buy
Sigma-Aldrich 12309 p-Benzoquinone for spectrophotometric det. of amines, ≥99.5% (HPLC) 106-51-4 25g $87.6 2021-03-22 Buy
Sigma-Aldrich 8.02410 p-Benzoquinone for synthesis 106-51-4 1 kg $142.45 2021-03-22 Buy
Sigma-Aldrich 1056504 1,4-Benzoquinone United States Pharmacopeia (USP) Reference Standard 106-51-4 200mg $373 2021-03-22 Buy
Sigma-Aldrich 8.02410 p-Benzoquinone for synthesis 106-51-4 25 kg $2950.75 2021-03-22 Buy

1,4-Benzoquinone Chemical Properties,Uses,Production


Quinone (p-benzoquinone) exists as a large yellow, monoclinic prism with an irritating odour resembling that of chlorine. Quinone is extensively used as a chemical intermediate, a polymerisation inhibitor, an oxidising agent, a photographic chemical, a tanning agent, and a chemical reagent. Quinone (p-benzoquinone) was first produced commercially in 1919 and has since been manufactured in several European countries. Its major use is in hydroquinone production, but it is also used as a polymerisation inhibitor and as an intermediate in the production of a variety of substances, including rubber accelerators and oxidising agents. It is used in the dye, textile, chemical, tanning, and cosmetic industries. In chemical synthesis for hydroquinone and other chemicals, quinone is used as an intermediate. It is also used in the manufacturing industries and chemical laboratory associated with protein fibre, photographic film, hydrogen peroxide, and gelatin making. Occupational exposure to quinone may occur in the dye, textile, chemical, tanning, and cosmetic industries. Inhalation exposure to quinone may occur from tobacco smoke.

Chemical Properties

Quinone is a yellow, crystalline material or large yellow, monoclinic prisms. Pungent, irritating odor.
1,4-Benzoquinone or p-benzoquinone is the basic structure of quinonoid compounds.They are widely distributed in the natural world, being found in bacteria, plants and arthropods and hence quinones are ubiquitous to living systems. Quinones play pivotal role in biological functions including oxidative phosphorylation and electron transfer.

Physical properties

Light yellow crystals with an acrid odor resembling chlorine. Odor threshold concentration is 84 ppb (quoted, Amoore and Hautala, 1983).


1,4-Benzoquinone is used in the manufactureof dyes, fungicide, and hydroquinone; fortanning hides; as an oxidizing agent; and inphotography.


Oxidizing agent; in photography; manufacture of dyes; manufacture of hydroquinone; tanning hides; making gelatin insoluble; strengthening animal fibers; as reagent.


As an oxidizing agent; in photography; tanning hides; intermediate in the manufacturing of dyes, fungicides, and hydroquinone.


Preparation of Quinone (p-Benzoquinone) from Hydroquinone.
Principle: Hydroquinone can be readily oxidized to quinone by using oxidizing agent like potassium dichromate and conc. H2SO4 or KBrO3.
Preparation of Quinone (p-Benzoquinone) from Hydroquinone
Procedure: Take 0.5 g hydroquinone and 5 ml distilled water in a beaker (25 ml). Heat on a wire gauze to obtain a clear solution. Take 1 g potassium dichromate (K2Cr2O7) in a conical flask and dissolve in 10 ml water and add 1 ml conc. H2SO4. Shake and cool the conical flask in ice water. To this ice cold solution add hydroquinone solution (prepared above) dropwise over a period of 30 minutes with constant shaking. Do not allow the temperature to rise above 20oC. After complete addition, continue shaking for further 10 minutes. Yellow crystals of quinone separate out. Filter on a Buchner funnel and dry it well. (Note: Do not wash with water as the product is water soluble). Record the practical yield and re-crystallize from ethyl alcohol.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The yellow needles of quinone separate out. Filter, dry and record the melting point and TLC (using toluene as a solvent).

Production Methods

Quinone was produced as early as 1838 by oxidation of quinic acid with manganese dioxide. Quinone can be prepared by oxidation starting with aniline or by the oxidation of hydroquinone with bromic acid. More recently, quinone has been made biosynthetically from D-glucose.


ChEBI: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.

Synthesis Reference(s)

Chemistry Letters, 14, p. 603, 1985
The Journal of Organic Chemistry, 48, p. 5160, 1983 DOI: 10.1021/jo00174a003
Tetrahedron Letters, 29, p. 677, 1988 DOI: 10.1016/S0040-4039(00)80182-3

General Description

A yellowish-colored crystalline solid with a pungent, irritating odor. Poisonous by ingestion or inhalation of vapors. May severely damage skin, eyes and mucous membranes. Used to make dyes and as a photographic chemical.

Air & Water Reactions

Soluble in water and denser than water. If moist 1,4-Benzoquinone may decompose spontaneously above 140°F. This has occurred in drums, causing over-pressurization.

Reactivity Profile

1,4-Benzoquinone acts as an oxidizing agent .


Toxic by inhalation, strong irritant to skin, eyes and mucous membranes. Skin damage. Ques- tionable carcinogen.

Health Hazard

1,4-Benzoquinone is moderately toxic viaingestion and skin contact. It is a mutagen andmay cause cancer. Because of its low vaporpressure, 0.1 torr (at 25°C 77°F), the healthhazard due to inhalation of its vapor is low.However, prolonged exposure may produceeye irritation, and its contact with the eyes can injure the cornea. Contact with the skincan lead to irritation, ulceration, and necrosis.
The toxicity of benzoquinone is similarto that of hydroquinone and benzenetriol.Repeated intraperitoneal administration of2 mg/kg/day to rats for 6 weeks produced significantdecreases in red blood cell, bone marrowcounts, and hemoglobin content (Raoet al. 1988). In addition, relative changes inorgan weights and injuries to the liver, thymus,kidney, and spleen were observed. Lauet al. (1988) investigated the correlation oftoxicity with increased glutathione substitutionin 1,4-benzoquinone. With the exceptionof the fully substituted isomer, increased substitutionresulted in enhanced nephrotoxicity.Although the conjugates were more stable tooxidation, the toxicity increased. The oral andintravenous toxicities of this compound in ratsare as follow:
LD50 value, oral (rats): 130 mg/kg
LD50 value, intravenous (rats): 25 mg/kg
The carcinogenicity of 1,4-benzoquinone inhumans is not reported. However, it is amutagen. It produced tumors in the lungs andskin of mice.

Fire Hazard

Noncombustible solid; ignition can occur after only moderate heating, autoignition temperature 560°C (1040°F); fire-extinguishing agent: water spray. 1,4-Benzoquinone may react violently with strong oxidizers, especially at elevated temperatures.

Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental tumorigenic data by skin contact. Human mutation data reported. Quinone has a characteristic, irritating odor. Causes severe damage to the skin and mucous membranes by contact with it in the solid state, in solution, or in the form of condensed vapors. Locally, it causes dlscoloration, severe irritation, erythema, swehng, and the formation of papules and vesicles, whereas prolonged contact may lead to necrosis. When the eyes become involved, it causes dangerous disturbances of vision. The moist material self-heats and decomposes exothermically above 60℃. When heated to decomposition it emits acrid smoke and fumes.

Potential Exposure

Due to this compound’s ability to react with certain nitrogen compounds to form colored sub- stances, quinone is widely used in the dye, textile, chemi- cal, tanning, and cosmetic industries. It is used as an industrial chemical; laboratory reagent; and as an interme- diate in chemical synthesis for hydroquinone and other chemicals.


Quinone has been tested for carcinogenicity in mice by skin application or inhalation and in rats by subcutaneous injection. None of these studies were considered sufficient to evaluate carcinogenicity (335, 336). A cancer bioassay of Tribolium-infested flour has been conducted but lack of quantification of quinone and methodological issues make the data difficult to interpret.
Quinone has produced negative results in studies designed to examine its ability to promote carcinogenicity. In a liver bioassay, quinone did not increase the formation of GGTpositive foci in the liver. Quinone did not promote induction of stomach or skin tumors in mice dosed with 7,12- dimethylbenzanthracene.

Environmental Fate

Quinone exists in the atmosphere in the gas phase. The dominant atmospheric loss process for quinone is expected to be by reaction with the hydroxyl (OH) radical (reaction with ozone is expected to be slow because of the >C(O) substituent groups). The estimated half-life and lifetime of quinone in the atmosphere due to reaction with the OH radical are w3 and 4 h, respectively. Release of 1,4-benzoquinone to the environment occurs via its effluents during its commercial production and use and in wastewaters from the coal industry. If released to soil, it is likely to leach (estimated Koc of 30) and may volatilize and photodegrade on soil surfaces. The ambient atmospheric concentration of 1,4-benzoquinone has been reported to be less than 15–80 ng m-3, and benzoquinone has been detected in tobacco smoke.


UN2587 Benzoquinone, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify p-benzoquinone in one or more of the following ways: steam distillation followed by filtration and drying (e.g. in a desiccator over CaCl2), crystallisation from pet ether (b 80-100o), *benzene (with, then without, charcoal), water or 95% EtOH, sublimation under vacuum (e.g. from room temperature to liquid N2). It slowly decomposes and should be stored, refrigerated, in an evacuated or sealed glass vessel in the dark. It should be resublimed before use. [Wolfenden et al. J Am Chem Soc 109 463 1987, Beilstein 7 IV 2065.]

Toxicity evaluation

The acute narcotic effects are due to the physical interaction of quinone itself on the cells of the central nervous system (CNS). The long-term effects are most likely due to the production of an unstable reactive intermediate during biotransformation or redox cycling. Cytochrome P450–mediated xenobiotic metabolism often leads to biological intermediates with attributes identical to quinones.


Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, some combustible substances; reducing agents. Decomposes exothermically on warming above 60 ? C, when moist, producing carbon monoxide.

Waste Disposal

Controlled incineration (982℃, 2.0 seconds minimum).

1,4-Benzoquinone Preparation Products And Raw materials

Raw materials

Preparation Products

1,4-Benzoquinone Suppliers

Global( 368)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
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86-0551-65418684 China 3001 55
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022-66880086 CHINA 537 58
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2021-10-14 Benzoquinone
US $17.00 / KG 25KG 99.99% 20 tons Hebei Dongdu Import and Export Co. LTD
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1,4-Benzoquinone Spectrum

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