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trans-4-Hydroxy-L-proline methyl ester hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride structure

CAS No.: 40216-83-9

Chemical Name:: trans-4-Hydroxy-L-proline methyl ester hydrochloride

Synonyms: METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE;H-HYP-OME HCL;4-Hydroxy-L-proline methyl ester hydrochloride;trans-4-Hydroxyproline Methyl Ester Hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;Hyp-Ome HCL;H-HYP-OME·HCL;L-Hyp-OMe·HCl;-4-HydroxyproL;H-L-HYP-OME HCL

CBNumber:: CB9351552

Molecular Formula:: C6H12ClNO3

Molecular Weight:: 181.62

MDL Number:: MFCD00080855

MOL File:: 40216-83-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

Product description	Number	Pack Size	Price
L-4-Hydroxyproline methyl ester hydrochloride ≥98.0% (TLC)	30681	5g	$60.4
trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride	H1533	5G	$42
trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride	H1533	25G	$126
trans-4-Hydroxy-L-proline methyl ester hydrochloride	279443	50g	$337
trans-4-Hydroxy-L-proline methyl ester hydrochloride	H952395	50g	$340
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trans-4-Hydroxy-L-proline methyl ester hydrochloride Properties

Melting point	169 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
color	White to Off-White
BRN	4716932
Stability	Hygroscopic
InChI	InChI=1/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/s3
InChIKey	KLGSHNXEUZOKHH-SRJSDOSHNA-N
SMILES	[C@@H]1(NC[C@H](O)C1)C(=O)OC.Cl \|&1:0,3,r\|
CAS DataBase Reference	40216-83-9(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315-H335

Precautionary statements

P261-P271-P280

Hazard Codes

Safety Statements

24/25

WGK Germany

HS Code

29339900

NFPA 704

	1
0		0

trans-4-Hydroxy-L-proline methyl ester hydrochloride price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	30681	L-4-Hydroxyproline methyl ester hydrochloride ≥98.0% (TLC)	40216-83-9	5g	$60.4	2025-07-31	Buy
TCI Chemical	H1533	trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride	40216-83-9	5G	$42	2025-07-31	Buy
TCI Chemical	H1533	trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride	40216-83-9	25G	$126	2025-07-31	Buy
Usbiological	279443	trans-4-Hydroxy-L-proline methyl ester hydrochloride	40216-83-9	50g	$337	2021-12-16	Buy
TRC	H952395	trans-4-Hydroxy-L-proline methyl ester hydrochloride	40216-83-9	50g	$340	2021-12-16	Buy

Product number	Packaging	Price	Buy
30681	5g	$60.4	Buy
H1533	5G	$42	Buy
H1533	25G	$126	Buy
279443	50g	$337	Buy
H952395	50g	$340	Buy

trans-4-Hydroxy-L-proline methyl ester hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

32968-78-8

40216-83-9

The general procedure for synthesizing trans-4-hydroxy-L-proline methyl ester hydrochloride from methanol and trans-4-hydroxy-L-proline hydrochloride is as follows: Example 1: (2S,4R)-4-hydroxy-2-pyrrolidine carboxylic acid hydrochloride (1.0 g, 7.6 mmol) was dissolved in methanol (25 mL) and cooled to 0°C. Thionyl chloride (0.83 mL, 11.4 mmol) was added slowly under stirring. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure to afford trans-4-hydroxy-L-proline methyl ester hydrochloride (1.2 g, 92% yield) in white solid form. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6).

IC 50

Non-cleavable Linker

References

[1] Organic Letters, 2018, vol. 20, # 1, p. 162 - 165
[2] Patent: WO2013/174937, 2013, A1. Location in patent: Page/Page column 74
[3] Patent: US2015/152048, 2015, A1. Location in patent: Paragraph 0447-0448

trans-4-Hydroxy-L-proline methyl ester hydrochloride synthesis

Synthesis of trans-4-Hydroxy-L-proline methyl ester hydrochloride from Methanol and Boc-Hyp-OH

trans-4-Hydroxy-L-proline methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Methanol Trans-4-Hydroxy-L-proline Hydrochloride Boc-Hyp-OH L-Hydroxyproline Acetyl chloride

Preparation Products

N-Boc-4-oxo-L-Proline methyl ester 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine N-BOC-cis-4-fluoro-L-proline (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride Glycine, L-prolyl-(4R)-4-hydroxy-L-prolyl-

trans-4-Hydroxy-L-proline methyl ester hydrochloride Suppliers

Global( 417)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8617390183901	cynthia@enlaibio.com	China	1100	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13505	58
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Chengdu Pukang Biotechnology Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from trans-4-Hydroxy-L-proline methyl ester hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-13	trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9	US $0.00 / Kg/Bag	100g	98.0%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2025-11-12	H-L-Hyp-Ome·HCl 40216-83-9	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-11-26	trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

trans-4-Hydroxy-L-proline methyl ester hydrochloride
40216-83-9
US $0.00 / Kg/Bag
98.0%min
WUHAN FORTUNA CHEMICAL CO., LTD

H-L-Hyp-Ome·HCl
40216-83-9
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

trans-4-Hydroxy-L-proline methyl ester hydrochloride
40216-83-9
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

trans-4-Hydroxy-L-proline methyl ester hydrochloride Spectrum

trans-4-Hydroxy-L-proline methyl ester hydrochloride(40216-83-9)¹HNMR

40216-83-9(trans-4-Hydroxy-L-proline methyl ester hydrochloride)Related Search:

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Trans-4-Hydroxy-L-proline Hydrochloride Thiophanate-methyl trans-4-Hydroxy-D-proline

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H-L-HYP-OME HCL HYDROXYPROLINE-OME HCL L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT L-HYDROXYPROLINE METHYL ESTER HCL L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE SALT TRANS-L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE TIMTEC-BB SBB003740 H-HYP-OME·HCL 4-HYDROXY-L-PROLINE METHYL ESTER HCl (2s,4r)-Methyl 4-Hydroxy-Pyrrolidine-2-Carboxylate HCl Hyp-Ome HCL (2S,4R)-4-hydroxy-L-proline methyl ester L-4-HYDROXYPROLINE METHYL ESTER HYDROCHL (2R,4S)-4-hydroxy-D-proline methyl ester Methyl (2S,4R)-4-hydroxy-2-prolinate hydrochloride TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HCL L-Hyp-OMe·HCl L-4-trans-Hydroxyproline methyl ester hydrochloride≥ 97% (HPLC) (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride L-4-Hydroxyproline methyl ester hydrochloride ,98% Methyl (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylate Hydrochloride Methyl L-Hydroxyprolinate Hydrochloride Methyl trans-4-Hydroxy-L-prolinate Hydrochloride trans-4-Hydroxy-L-proline Methyl ester hydrochloride trans-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride 4-hydroxy-pyrrolidine-2-carboxylic acid Methyl ester hydrochloride Trans-4-hydroxyl-lprolinemethylesterhydrochloride Methyl (2S)-1-hydroxypyrrolidine-2-carboxylate hydrochloride L-(S)-4-Hydroxyproline Methyl Ester Hydrochloride trans-4-Hydroxy-L-proline methyl ester hydrochloride, Methyl (4R)-4-hydroxy-L-prolinate hydrochloride L-4-Hydroxyproline Methyl ester hydrochloride >=98.0% (TLC) L-4-Hydroxyproline Methyl ester hydrochloride, 95+% L-4-Hydroxyproline methyl ester (2S,4R)-trans-4-hydroxy-L-proline methyl ester hydrochloride 4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester hydrochloride H-Hyp-OMe·HCl (Non-animal Origin) Hydroxyproline methyl ester hydrochloride (4R)-4-Hydroxy-L-proline methyl ester HCl trans-4-Hydroxy-L-prolineMethylEsterHydrochloride> -4-HydroxyproL (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride trans-4-Hydroxy-L-proline methyl ester hydrochloride USP/EP/BP H-Hyp-OMe (hydrochloride) H-HYP-OME HCL METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE (2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE 4-Hydroxy-L-proline methyl ester hydrochloride trans-4-Hydroxyproline Methyl Ester Hydrochloride (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester HCl (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/trans-4-HYDROXY-L-PROLINE METHYL ESTER Hydrochloride L-4-Hydroxyproline methyl ester hydrochloride 40216-83-9