CLASTO-LACTACYSTIN BETA-LACTONE
- CAS No.
- 154226-60-5
- Chemical Name:
- CLASTO-LACTACYSTIN BETA-LACTONE
- Synonyms
- OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-Lactacystin β-lactone;clasto-lactacystin β-lactone;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-
- CBNumber:
- CB9352564
- Molecular Formula:
- C10H15NO4
- Molecular Weight:
- 213.23
- MDL Number:
- MFCD01076526
- MOL File:
- 154226-60-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H319 | |||||||||
Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 20/21/22-37/38-41-36/37/38-25 | |||||||||
Safety Statements | 16-26-36/37/39-45 | |||||||||
RIDADR | UN 2811 6.1 / PGIII | |||||||||
WGK Germany | 2 | |||||||||
NFPA 704 |
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CLASTO-LACTACYSTIN BETA-LACTONE price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | L7035 | clasto-Lactacystin β-lactone | 154226-60-5 | 0.1mg | $434 | 2024-03-01 | Buy |
Sigma-Aldrich | 426102 | clasto-Lactacystinβ-Lactone-CAS154226-60-5-Calbiochem Ahighlyspecific,cell-permeable,andirreversible20Sproteasomeinhibitor. | 154226-60-5 | 100μg | $223.8 | 2024-03-01 | Buy |
Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 50μg | $65 | 2024-03-01 | Buy |
Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 100μg | $124 | 2024-03-01 | Buy |
Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 500μg | $488 | 2024-03-01 | Buy |
CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
Uses
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
Uses
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Biological Activity
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.
CLASTO-LACTACYSTIN BETA-LACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
CLASTO-LACTACYSTIN BETA-LACTONE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
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