5-Chloro-2-fluorobenzyl bromide
- CAS No.
- 71916-91-1
- Chemical Name:
- 5-Chloro-2-fluorobenzyl bromide
- Synonyms
- -bromo-3-chloro-6-fluorotoluene;5-CHLORO-2-FLUOROBENZYL BROMIDE;2-Fluoro-5-chlorobenzyl bromide;à-bromo-3-chloro-6-fluorotoluene;5-Chloro-2-fluorobenzyl Bromide >alpha-Bromo-3-chloro-6-fluorotoluene;1-(Bromomethyl)-5-chloro-2-fluorobenzene;2-(Bromomethyl)-4-chloro-1-fluorobenzene;Benzene, 2-(bromomethyl)-4-chloro-1-fluoro-;5-Chloro-2-fluoronitrobenzenebenzyl bromide
- CBNumber:
- CB9352928
- Molecular Formula:
- C7H5BrClF
- Molecular Weight:
- 223.47
- MDL Number:
- MFCD01631437
- MOL File:
- 71916-91-1.mol
| Product description | Number | Pack Size | Price |
| 5-Chloro-2-fluorobenzyl Bromide >97.0%(GC) | C2360 | 5g | $63 |
| 2-(bromomethyl)-4-chloro-1-fluoro-Benzene | B100610 | 5g | $100 |
| 5-Chloro-2-fluorobenzyl bromide 98% | 002100 | 25g | $280 |
| 5-CHLORO-2-FLUOROBENZYL BROMIDE 95.00% | HCH0024693 | 5G | $865.1 |
| 5-CHLORO-2-FLUOROBENZYL BROMIDE 95.00% | HCH0024693 | 10G | $1265.88 |
| More product size | |||
| Melting point | 45°/0.5mm |
|---|---|
| Boiling point | 44-45°C 0,5mm |
| Density | 1.65 |
| refractive index | 1.565 |
| Flash point | 44-45°C/0.5mm |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| Sensitive | Lachrymatory |
| BRN | 637765 |
| CAS DataBase Reference | 71916-91-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H227-H290-H314 | |||||||||
| Precautionary statements | P210-P234-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P403+P235-P405-P406-P501-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | C,Xn | |||||||||
| Risk Statements | 34-36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | 3265 | |||||||||
| Hazard Note | Corrosive/Lachrymatory | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29039990 | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
5-Chloro-2-fluorobenzyl bromide price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2360 | 5-Chloro-2-fluorobenzyl Bromide >97.0%(GC) | 71916-91-1 | 5g | $63 | 2025-07-31 | Buy |
| TRC | B100610 | 2-(bromomethyl)-4-chloro-1-fluoro-Benzene | 71916-91-1 | 5g | $100 | 2021-12-16 | Buy |
| Matrix Scientific | 002100 | 5-Chloro-2-fluorobenzyl bromide 98% | 71916-91-1 | 25g | $280 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0024693 | 5-CHLORO-2-FLUOROBENZYL BROMIDE 95.00% | 71916-91-1 | 5G | $865.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0024693 | 5-CHLORO-2-FLUOROBENZYL BROMIDE 95.00% | 71916-91-1 | 10G | $1265.88 | 2021-12-16 | Buy |
5-Chloro-2-fluorobenzyl bromide Chemical Properties,Uses,Production
Uses
2-(bromomethyl)-4-chloro-1-fluoro-Benzene is a useful reactant which has been used in the synthesis of potential cell cycle inhibitors in HepG2 cells.
Synthesis
452-66-4
71916-91-1
General procedure for the synthesis of 5-chloro-2-fluorobenzyl bromide from 5-chloro-2-fluorotoluene: A: 5-Chloro-2-fluorotoluene (100 g, 692 mmol) was dissolved in ethyl acetate (300 ml) at 20 °C. To this solution N-bromosuccinimide (147.7 g, 830 mmol) and dibenzoyl peroxide (2 g, 8.25 mmol) were added sequentially. The reaction mixture was heated to 80 °C and stirred for 3 hours. Upon completion of the reaction, heptane (300 ml) was added and the mixture was cooled to 0 °C, at which time the succinimide precipitated. After filtration and washing with heptane, the residue was washed with water (1500 ml). The filtrate was concentrated to dryness under vacuum to give 162 g of the crude product 5-chloro-2-fluorobenzyl bromide. The crude product (141 g) was purified by vacuum distillation at 99 °C and 33 mbar to give the final 5-chloro-2-fluorobenzyl bromide (99 g, 75% yield). The purity of the product was analyzed by GC to be 87.1% (% area).1H-NMR (CDCl3) data: δ 4.44 (2H, d, CH2), 7.01 (1H, t, H3), 7.26 (1H, m, H4), 7.38 (1H, m, H6).
References
[1] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 27 - 32
[2] Patent: WO2008/3460, 2008, A1. Location in patent: Page/Page column 23-24
[3] Patent: US2008/9619, 2008, A1. Location in patent: Page/Page column 11-12
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 10, p. 3098 - 3105
[5] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 19, p. 2903 - 2909
5-Chloro-2-fluorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14359 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 5-Chloro-2-fluorobenzyl bromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 5-Chloro-2-fluorobenzyl bromide
71916-91-1
|
US $1.00 / g | 1g | 99% | 10000KGS | Career Henan Chemical Co |
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- 5-Chloro-2-fluorobenzyl bromide
71916-91-1
- US $1.00 / g
- 99%
- Career Henan Chemical Co
