3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
- CAS No.
- 119139-23-0
- Chemical Name:
- 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
- Synonyms
- RO 31-6233;ARCYRIARUBIN A;3,4-Di(1H-indol-3-yl);BISINDOLYMALEIMIDE IV;BISINDOLYLMALEIMIDE IV;Sotrastaurin Impurity 13;3,4-BIS(3-INDOLYL)MALEIMIDE;2,3-BIS(1H-INDOL-3-YL)MALEIMIDE;BisindolylMaleiMide IV [Ro 31-6233];3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione
- CBNumber:
- CB9354568
- Molecular Formula:
- C20H13N3O2
- Molecular Weight:
- 327.34
- MDL Number:
- MFCD00236432
- MOL File:
- 119139-23-0.mol
- MSDS File:
- SDS
| Melting point | 161 °C |
|---|---|
| Boiling point | 690.1±55.0 °C(Predicted) |
| Density | 1.486±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 8.44±0.60(Predicted) |
| color | dark red |
| FDA UNII | MBK3OO5K8T |
3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B3306 | Bisindolylmaleimide IV ≥98% (TLC) | 119139-23-0 | 1mg | $104 | 2024-03-01 | Buy |
| TCI Chemical | B6068 | Bisindolylmaleimide IV | 119139-23-0 | 50MG | $143 | 2024-03-01 | Buy |
| TCI Chemical | B6068 | Bisindolylmaleimide IV | 119139-23-0 | 250MG | $494 | 2024-03-01 | Buy |
| Cayman Chemical | 13299 | Bisindolylmaleimide IV ≥98% | 119139-23-0 | 1mg | $53 | 2024-03-01 | Buy |
| Cayman Chemical | 13299 | Bisindolylmaleimide IV ≥98% | 119139-23-0 | 5mg | $227 | 2024-03-01 | Buy |
3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione Chemical Properties,Uses,Production
Definition
ChEBI: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
General Description
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 μM).
Biological Activity
bisindolylmaleimide iv is a protein kinase c (pkc) inhibitor.the enzyme family protein kinase c2 (pkc) occupies a central role in the transduction of signals from a variety of mediators across the cell membrane.3 receptor occupation by a number of hormones, cytokines, neurotransmitters, and growth factors results in activation of pkc via activation of phospholipase c through either a g protein mechanism or a tyrosine kinase mechanism. pkc then propagates the signal by phosphorylation of proteins on serine or threonine, with atp as cosubstrate, resulting in modification of the properties of these proteins. thus pkc appears to regulate mechanisms of cell proliferation, secretion, and gene expression.
Biochem/physiol Actions
Target IC50: 87 nM against protein kinase C
in vitro
bisindolylmaleimide iv was identified as a cell permeable inhibitor of protein kinase c (pkc) with ic50 values from 0.10 to 0.55 μm. bisindolylmaleimide iv was designed to be more discriminative than its parent compound staurosporine, the non-selective pkc inhibitor. in addition, bisindolylmaleimide iv also found to be able to inhibit protein kinase a with ic50 values ranging from 2 to 11.8 μm [1, 2].
in vivo
animal study found that, in neonatal rats, high glucose levels could induce the hypertrophy of cardiomyocytes. ro-31-8220, a analog of bisindolylmaleimide viii, was able to reverse the effect of high glucose on the cardiac myocytes, which might be through pkc/nf-κb/c-fos pathway [3].
IC 50
from 0.10 to 0.55 μm
References
[1] davis, p. d.,hill, c.h.,lawton, g., et al. inhibitors of protein kinase c. 1.1 2,3-bisarylmaleimides. journal of medicinal chemistry 35, 177-184 (1992).
[2] toullec, d. ,pianetti, p.,coste, h., et al. the bisindolylmaleimide gf 109203x is a potent and selective inhibitor of protein kinase c. the journal of biological chemisty 266(24), 15771-15781 (1991).
[3] zhang, w. b. et al. reverse effect of protein kinase c inhibitor ro-31-8220 on the hypertrophy of cardiomyocytes of neonatal rats induced by high glucose levels. chinese journal of pathophysiology. 2009-08.
3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
119139-23-0
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
119139-23-0
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co
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