MMP-2 SUBSTRATE, FLUOROGENIC
- CAS No.
- Chemical Name:
- MMP-2 SUBSTRATE, FLUOROGENIC
- Synonyms
- 390 MMP FRET SUBSTRATE III;MCA-PLA-NVA-DAP(DNP)-AR-NH2;MMP-2 SUBSTRATE, FLUOROGENIC;MCA-PRO-LEU-ALA-NVA-DPA-ALA-ARG-NH2;MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2
- CBNumber:
- CB9354821
- Molecular Formula:
- C50H70N14O15
- Molecular Weight:
- 1107.18
- MDL Number:
- MFCD02179367
- MOL File:
- Mol file
MMP-2 SUBSTRATE, FLUOROGENIC Chemical Properties,Uses,Production
Uses
Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases that degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. MCA-Pro-Leu-Ala-Nva-DNP-Dap-Ala-Arg-NH2; DNP-Pro-Leu-Gly-Met-Trp-Ser-Arg (DNP-PLGMWSR), Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 (DNP-PLGLWA-D-R-NH2), Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH (DNP-PQGIAGQ-D-R-OH) and MOCAc [(7-methoxy coumarin-4-yl) acetyl]-RPKPYANvaWMK(Dnp[2,4-dinitrophenyl])-NH(2) are substrates for matrix metalloproteinase 2.
General Description
Matrix metalloproteinases (MMPs) are localized to the nucleus, mitochondria, vesicles and cytoplasm. MMP family comprises of 25 members, of which 24 are present in mammals. MMPs are encoded as inactive enzymes and are localized to cell membranes. All MMP members possess pro domain (80 amino acids) and catalytic domains.
Biochem/physiol Actions
Matrix metalloproteinases (MMPs) are responsible for degrading membrane proteins, such as basal lamina proteins of cerebral blood vessels. Proteolysis of intracellular substrates by MMPs is associated with the innate immune system and apoptosis. They are also involved in disease conditions such as oncogenesis, cardiac, neurological and autoimmune disorders. MMPs are also associated with pathogenesis related to protein conformational changes. Elevated expression of a number of MMPs is observed in myocardial infarction and heart failure.
MMP-2 SUBSTRATE, FLUOROGENIC Preparation Products And Raw materials
Raw materials
Preparation Products
MMP-2 SUBSTRATE, FLUOROGENIC Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6119 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14092 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 17306812703 | 3007955328@qq.com | China | 5720 | 58 |
| Shanghai Toyang Biotechnology Co., LTD | 021-59555769 13524932310 | 1405894150@qq.com | China | 8221 | 58 |
| Wuhan Peptide Core Biotechnology Co., Ltd | 027-65317797 13667154760 | 1096814016@qq.com | China | 10013 | 58 |