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1,1,2,2-Tetrachloroethane

Description Chemical and Physical Properties Applications Methods of Preparation Hazard Statements
1,1,2,2-Tetrachloroethane
1,1,2,2-Tetrachloroethane structure
CAS No.
79-34-5
Chemical Name:
1,1,2,2-Tetrachloroethane
Synonyms
R-130;Cellon;Westrol;Westron;(CHCl2)2;Acetosol;Bonoform;freon130;a13-04597;NCI-C03554
CBNumber:
CB9384693
Molecular Formula:
C2H2Cl4
Formula Weight:
167.85
MOL File:
79-34-5.mol

1,1,2,2-Tetrachloroethane Properties

Melting point:
-43 °C
Boiling point:
147 °C(lit.)
Density 
1.586 g/mL at 25 °C(lit.)
vapor density 
5.8 (vs air)
vapor pressure 
8 mm Hg ( 20 °C)
refractive index 
n20/D 1.494(lit.)
Flash point:
142-146°C
storage temp. 
Store below +30°C.
solubility 
2830g/l
form 
Liquid
color 
slightly green-yellow
Water Solubility 
0.3 g/100 mL (25 ºC)
Merck 
14,9189
BRN 
969206
Henry's Law Constant
6.22 at 30 °C (headspace-GC, Sanz et al., 1997)
Exposure limits
Potential occupational carcinogen. NIOSH REL: TWA 1 ppm (7 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 5 ppm (35 mg/m3); ACGIH TLV: TWA 1 ppm (adopted).
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases. Reacts violently with sodium, potassium, nitrates, 2,4-dinitrophenyl disulphide.
CAS DataBase Reference
79-34-5(CAS DataBase Reference)
EWG's Food Scores
5
Proposition 65 List
1,1,2,2-Tetrachloroethane
IARC
2B (Vol. 20, Sup 7, 71, 106) 2014
NIST Chemistry Reference
Ethane, 1,1,2,2-tetrachloro-(79-34-5)
EPA Substance Registry System
1,1,2,2-Tetrachloroethane (79-34-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS09,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H331-H310-H370-H412-H330-H411-H310+H330-H341-H351
Precautionary statements  P304+P340-P320-P405-P501a-P210-P260-P273-P280-P301+P310-P302+P350-P284-P310-P262-P302+P352+P310-P304+P340+P310-P361+P364
Hazard Codes  T+,N,T,F
Risk Statements  26/27-51/53-59-39/23/24/25-23/24/25-11
Safety Statements  38-45-61-36/37-16-7
RIDADR  UN 1702 6.1/PG 2
WGK Germany  3
RTECS  KI8575000
TSCA  Yes
HS Code  2903 19 00
HazardClass  6.1
PackingGroup  II
Toxicity LD50 orally in rats: 0.20 ml/kg (Smyth)
NFPA 704
1
3 1

1,1,2,2-Tetrachloroethane price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.43948 1,1,2,2-Tetrachloroethane for synthesis 79-34-5 250 mL $31.63 2021-03-22 Buy
Sigma-Aldrich 8.43948 1,1,2,2-Tetrachloroethane for synthesis 79-34-5 1 L $91.57 2021-03-22 Buy
Sigma-Aldrich 185434 1,1,2,2-Tetrachloroethane reagent grade, ≥98.0% 79-34-5 500ml $126 2021-03-22 Buy
Sigma-Aldrich 185434 1,1,2,2-Tetrachloroethane reagent grade, ≥98.0% 79-34-5 1l $195 2021-03-22 Buy
TCI Chemical T0063 1,1,2,2-Tetrachloroethane >97.0%(GC) 79-34-5 25g $20 2021-03-22 Buy

1,1,2,2-Tetrachloroethane Chemical Properties,Uses,Production

Description

1,1,2,2-Tetrachloroethane is the chlorinated form of ethane and it illustrates a relatively high solvent potential when compared to all chlorinated hydrocarbons. Currently, the use of 1,1,2,2-Tetrachloroethane in the USA is restricted since air emissions of the compound originate from its application as a chemical catalyst in the synthesis of specific chemicals. The detection of low quantities of the compound in the air can have negative effects on the neurological system. Short-term/Acute inhalation exposure to concentrated 1,1,2,2-Tetrachloroethane can also have negative effects on the gastrointestinal system, the central nervous system, the respiratory system and the liver in humans. Prolonged exposure to 1,1,2,2-Tetrachloroethane through inhalation can result in an enlarged liver, drowsiness, numbness, dizziness, tremors, headaches and jaundice in humans.

Chemical and Physical Properties

1,1,2,2-Tetrachloroethane is a colourless, light yellow liquid with a characteristic odour which resembles that of chloroform. It has a molecular weight of 167.838 g/mol, a monoisotopic mass of 165.891 g/mol and an exact mass of 167.888 g/mol.
1,1,2,2-Tetrachloroethane has a heavy atom count of 6, a complexity of 6 and a topographical surface area of 0 A^2. It attains its boiling point at 146.0 deg C/295° F at 760 mm Hg. It has a melting point of -330 F/-42.3℃.
It dissolves in water at a rate of 2,830 mg/L at 25℃. 1 gram of the compound dissolves in 350 ml of water at 25℃. 1,1,2,2-Tetrachloroethane is soluble in acetone and it is miscible with ethanol, ether, dimethylformamide, oils, carbon disulfide, chloroform, carbon tetrachloride, petroleum ether, benzene and methanol.
1,1,2,2-Tetrachloroethane has a density of 1.595 at 68° F/1.5953 g/cu cm at 20℃. It has a relative density of 1.59, where water = 1 at 770 F. It also has a vapour density of 5.79 (Air=1) and a vapour pressure of 5 mm Hg at 70° F; 6 mm Hg at 77° F/5.74 mm Hg at 25℃.
1,1,2,2-Tetrachloroethane is stable in the absence of light, moisture and air even when exposed to high temperatures. However, heat may contribute to the compounds instability.
When the compound is exposed to air, it evolves gradually into trichloroethylene and small quantities of phosgene. The exposure of 1,1,2,2-Tetrachloroethane to moisture results in its decomposition which results in the formation of hydrochloric acid.
In the presence of ultraviolet radiation, the compound decomposes to produce 2,2-dichloroacetyl chloride. When 1,1,2,2-Tetrachloroethane comes into contact with hot metal surfaces, incandescent material or a flame, it decomposes with the evolution of carbon monoxide, carbon dioxide and hydrochloric acid.
1,1,2,2-Tetrachloroethane is a corrosive liquid which can attack certain forms of coatings, rubber or plastics.

Applications

The synthesis of 1,1,2,2-tetrachloroethane in the United States has decreased in recent years. Previously, the compound synthesized as a by-product for the manufacture of large volumes of 1,2,-dichloroethylene tetrachloroethylene, and trichloroethylene. 1,1,2,2-tetrachloroethane was also used in pesticide, as an extractant for fats and oils, in photographic films, lacquers and varnishes, in paint removers, in degreasing and cleaning metals, and as a solvent.

Methods of Preparation

1,1,2,2-tetrachloroethane is synthesized by the addition of chlorine as a catalyst to acetylene; by chlorination of 1,2-dichloroethane; by catalytic chlorination of ethane; by direct oxychlorination/chlorination of ethylene. 1,1,2,2-tetrachloroethane is not isolated from the reaction in most cases but it is readily cracked at 454℃ to produce tetrachloroethylene and trichloroethylene products. To obtain a high purity compound, 1,1,2,2tetrachloroethane can be obtained by chlorinating acetylene.
Commercial processes for the synthesis of the compound can be classified into two main routes, where chlorine is added to acetylene and the liquid-phase which entails the chlorination of 1,2-dichloroethane or ethylene. The liquid-state chlorination of 1,1,2-trichloroethane or vinyl chloride with the catalytic action of AlCl3 results in a highly selective 1,1,2,2-tetrachloroethane.

Hazard Statements

1,1,2,2-tetrachloroethane is toxic if swallowed and it may result in acute toxicity/irritation/corrosion upon contact with the skin. It can cause significant eye damage and it can also result in acute toxicity/fatality upon inhalation. 1,1,2,2-tetrachloroethane causes dizziness/drowsiness and it is associated with specific organ toxicity based and narcotic effects. Based on single or prolonged exposure, the compound could result in target organ damage.
1,1,2,2-tetrachloroethane is a powerful narcotic but it can result in liver poisoning, which may also be accompanied by neurological disturbances and modifications in the composition of blood. Prolonged exposure to the compound through inhalation can be fatal. Ingestion of the compound results in loss of reflexes, unconsciousness, cyanosis, liver necrosis, severe mucosal injury, diarrhoea, vomiting and death. Contact with the eyes also results in lachrymation and irritation. It can be absorbed through dermal routes hence it may also induce the development of lesions.
Special hazards in regards to exposure of the compound to fire suggest that it may produce irritating/toxic hydrogen chloride vapours.

Description

1,1,2,2-Tetrachloroethane (tetrachloroethane) is a volatile, synthetic, colorless to pale-yellow dense liquid with a pungent, chloroform-like odor that is soluble in water and most organic solvents. There are no known natural sources of tetrachloroethane. Tetrachloroethane is a chemical intermediate in the production of a variety of other common chemicals. In the past, the major use for tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. With the development of new processes for manufacturing chlorinated ethylenes and the availability of less-toxic solvents, the production of tetrachloroethane as a commercial endproduct in the United States and Canada has steadily declined since the late 1960s and the production ceased by the early 1990s. Although at one time it was used as an insecticide, fumigant, and weed killer, it presently is not registered for any of these purposes. Its registration as an insect repellent was canceled by the Environmental Protection Agency (EPA) in the late 1970s.

Chemical Properties

colourless to light yellow liquid with a chloroform-like

Chemical Properties

Tetrachloroethane is a heavy, volatile colorless to light yellow liquid. It has a sweetish, chloroform-like odor. The Odor Threshold is 0.5 ppm in water and 1.5 ppm in air.

Physical properties

Colorless to pale yellow liquid with a sweet, chloroform-like odor. A detection odor threshold concentration of 50 mg/m3 (7.3 ppmv) was experimentally determined by Dravnieks (1974).

Uses

Nonflammable solvent for fats, oils, waxes, resins, cellulose acetate, rubber, copal, phosphorus, sulfur. As solvent in certain types of Friedel-Crafts reactions or phthalic anhydride condensations. In the manufacture of paint, varnish, and rust removers. In soil sterilization and weed killer and insecticide formulations. In the determination of theobromine in cacao. As immersion fluid in crystallography. In the biological laboratory to produce pathological changes in gastrointestinal tract, liver, and kidneys. Intermediate in the manufacture of trichloroethylene and other chlorinated hydrocarbons having two carbon atoms.

Uses

1,1,2,2-Tetrachloroethane, once used as a solvent for cleaning and extraction processes, is still used to some extent as a chemical intermediate. Present usage is quite limited because less toxic solvents are available.

Uses

Intermediate in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene; previously used as a solvent, insecticide and fumigant.

Definition

ChEBI: A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1, 2 and 2.

General Description

Colorless to pale yellow liquid with a sweet odor. Sinks in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1,1,2,2-Tetrachloroethane may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Decomposed by heat and UV light, forming phosgene and HCl; reacts violently with finely dispersed metals [Handling Chemicals Safely 1980. p. 886].

Hazard

Toxic by ingestion, inhalation, skin absorption. Questionable carcinogen.

Health Hazard

Compound is a powerful narcotic and liver poison; may also cause changes in blood composition and neurological disturbances. Repeated exposure by inhalation can be fatal. Ingestion causes vomiting, diarrhea, severe mucosal injury, liver necrosis, cyanosis, unconsciousness, loss of reflexes, and death. Contact with eyes causes irritation and lachrymation. Can be absorbed through the skin and may produce severe skin lesions.

Fire Hazard

Special Hazards of Combustion Products: Irritating hydrogen chloride vapor may form in fire.

Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Poison by inhalation, ingestion, and intraperitoneal routes. Moderately toxic by several other routes. Mutation data reported. Human central nervous system effects by ingestion and inhalation: general anesthesia, somnolence, hallucinations, and distorted perceptions. Considered the most toxic of the common chlorinated hydrocarbons. Considered to be a very severe industrial hazard and its use has been restricted or even forbidden in certain countries. It is not an inert solvent. Reacts violently with N2O4,2,4dinitrophenyl disulfide, and on contact with sodium or potassium. When heated in contact with solid potassium hydroxide, spontaneously flammable chloroor dichloroacetylene gas is evolved. Any water can cause appreciable hydrolysis, even at room temperature, and both hydrolysis and oxidation become comparatively rapid above 110'. When heated to decomposition it emits toxic fumes of Cl-. A strong irritant of eyes and mucous membranes. A concentration of 3 ppm produces a detectable odor, thus an initial produces a detectable odor, thus an initial warning effect. Its narcotic action is stronger than that of chloroform, but, because of its low volatility, narcosis is less severe and much less common in industrial poisoning than in the case of other chlorinated hydrocarbons. The toxic action of this material is chiefly on the liver, where it produces acute yellow atrophy and cirrhosis. Fatty degeneration of the kidneys and heart, hemorrhage into the lungs and serous membranes, and edema of the brain have also been found in fatal cases. Some reports indicate a toxic action on the central nervous system with changes in the brain and in the peripheral nerves. The effect on the blood is one of hemolysis with appearance of young cells in the circulation and a monocptosis. Due to its solvent action on the natural skin oils, dermatitis is not uncommon. The initial symptoms resulting from exposure to the vapor are lachrymation, salivation, and irritation of the nose and throat. Continued exposure to high concentrations results in restlessness, dizziness, nausea, vomiting, and narcosis. The latter, however, is rare in industry. More commonly, exposure is less severe and most complaints are vague and related to the digestive and nervous systems. The patient's symptoms gradually progress to a more serious illness with development of toxic jaundice, liver tenderness, etc., and possibly albuminuria and edema. With serious liver damage, the jaundice increases and toxic symptoms appear, with somnolence, delirium, convulsions, and coma usually precedmg death. See also ACETYLENE COMPOUNDS and CHLORIDES.

Potential Exposure

Tetrachloroethane is used as an intermediate in the trichloroethylene production from acetylene and as a solvent; as a dry cleaning agent; as a fumigant; in cement; and in lacquers. It is used in the manufacture of artificial silk, artificial leather, and artificial pearls. Recently, its use as a solvent has declined due to replacement by less toxic compounds. It is also used in the estimation of water content in tobacco and many drugs, and as a solvent for chromium chloride impregnation of furs.

Carcinogenicity

The EPA has classified this material as “likely to be carcinogenic to humans” based on data from an oral cancer bioassay in male and female Osborne–Mendel rats and B6C3F1 mice. In mice, a significant increase in the incidence of hepatoceullar carcinomas in both genders was observed. Male Osborne–Mendel rats showed increased incidence of hepatocellular carcinomas, which is a rare tumor in this strain.
The National Cancer Institute has included 1,1,2,2- tetrachloroethane in their bioassay series using rats and mice. Their summary states that the time-weighted average doses (by gavage) were 108 and 62 mg/kg/day for male rats, 76 and 43 mg/kg/day for female rats, and 282 and 142 mg/kg/day for all mice. There was a highly significant positive dose-related trend in the incidence of hepatocellular carcinoma in mice of both sexes. No statistically significant incidence of neoplastic lesions was observed in male or female rats. However, two hepatocellular carcinomas and one neoplastic nodule, which are rare tumors in the male Osborne–Mendel rat, were observed in high-dose males. Under the conditions of this bioassay, orally administered 1,1,2,2-tetrachloroethane was a liver carcinogen in B6C3Fl mice of both sexes.
The proposed metabolic pathway involves the production of dichloroacetic acid, which was identified as the major urinary metabolite in treated mice. Other pathways involve formation of trichloroethylene via dehydrochlorination or tetrachloroethylene via oxidation. Free radicals may also be formed.
From the NCI study, a oral slope factor (OSF) of 0.2 per mg/kg/day was developed by the EPA. No inhalation unit risk (IUR) was determined by the EPA because of absence of data from inhalation exposure.

Environmental Fate

Biological. Monodechlorination by microbes under laboratory conditions produced 1,1,2- trichloroethane (Smith and Dragun, 1984). In a static-culture-flask screening test, 1,1,2,2- tetrachloroethane (5 and 10 mg/L) was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. No significant degradation was observed after 28 d of incubation (Tabak et al., 1981).
Chemical/Physical. In an aqueous solution containing 0.100 M phosphate-buffered distilled water, 1,1,2,2-tetrachloroethane was abiotically transformed to 1,1,2-trichloroethane. This reaction was investigated within a temperature range of 30 to 95 °C at various pHs (5 to 9) (Cooper et al., 1987). Abiotic dehydrohalogenation of 1,1,2,2-tetrachloroethane yielded trichloroethylene (Vogel et al., 1987) and HCl (Kollig, 1993). The half-life for this reaction at 20 °C was reported to be 0.8 yr (Vogel et al., 1987). Under alkaline conditions, 1,1,2,2-tetrachloroethane dehydrohalogenated to trichloroethylene. The reported hydrolysis half-life of 1,1,2,2-tetrachloroethane in water at 25 °C and pH 7 is 146 d (Jeffers et al., 1989).
The evaporation half-life of 1,1,2,2-tetrachloroethane (1 mg/L) from water at 25 °C using a shallow-pitch propeller stirrer at 200 rpm at an average depth of 6.5 cm was 55.2 min (Dilling, 1977).
At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 11, 4.5, 1.9, and 0.8 mg/g, respectively (Dobbs and Cohen, 1980).

Shipping

UN1702 Tetrachloroethane or 1,1,2,2Tetrachloroe thane, Hazard Class: 6.1; Labels: 6.1Poisonous materials.

Purification Methods

Stir the ethane, on a steam-bath, with conc H2SO4 until a fresh portion of acid remains colourless. The organic phase is then separated, distilled in steam, dried (CaCl2 or K2CO3), and fractionally distilled in a vacuum. [Beilstein 1 IV 144.]

Toxicity evaluation

Metabolism of tetrachloroethane to reactive products plays a key role in its toxicity. Both nuclear and microsomal cytochrome P450 enzymes have been implicated in the metabolism of the compound, possibly releasing aldehydes, alkenes, acids, and free radicals that may react with biological tissues. Therefore, because of high metabolic activity of the liver, the formation of active metabolites is a likely mechanism for the toxicity tetrachloroethane. Hence, tetrachloroethane metabolism could result in the reductive formation of radical products, leading to the stimulation of lipid peroxidation resulting in hepatotoxic effects, as noted in carbon tetrachloride, a structurally related chlorinated alkane. Both dichloroacetic and trichloroacetic acids are known to cause proliferation of peroxisomes.
The mechanism of neurological toxicity of tetrachloroethane has not been well characterized. Studies of similar compounds suggest that the parent compound itself may be the causative agent. This property allows interference with neural membrane function, bringing about central nervous system depression, behavioral changes, and anesthesia.
The mechanisms by which tetrachloroethane produces carcinogenic effects are incompletely characterized. Tetrachloroethane has been shown to bind to DNA in the liver and several other organs in rats and mice, which may contribute to the carcinogenic process. Studies indicate that there may be initiating and promoting activities when tetrachloroethane is metabolized, possibly by cytochrome P450 enzymes producing urinary metabolites such as dichloroacetic acid, trichloroacetic acid, trichloroethylene, and tetrachloroethylene. Studies of chronic exposure of rats and mice to these specific metabolites revealed hepatic tumors in male and female mice. Although it is possible that the carcinogenicity of tetrachloroethane involves metabolism with these compounds, there is no direct evidence linking one or more metabolites to its carcinogenic effects. Tetrachloroethane may be metabolized to form free radicals, which can in turn covalently bind to tissues, including DNA.

Incompatibilities

Violent reaction with chemically active metals; strong caustics; strong acids; especially fuming sulfuric acid. Degrades slowly when exposed to air. Attacks plastic and rubber.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

1,1,2,2-Tetrachloroethane Preparation Products And Raw materials

Raw materials

Preparation Products


1,1,2,2-Tetrachloroethane Suppliers

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View Lastest Price from 1,1,2,2-Tetrachloroethane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-13 1,1,2,2-Tetrachloroethane
79-34-5
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2019-07-12 1,1,2,2-Tetrachloroethane
79-34-5
US $1.00 / KG 1KG 99% 25kg career henan chemical co

1,1,2,2-Tetrachloroethane Spectrum


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