2-Chloroacetophenone
- CAS No.
- 532-27-4
- Chemical Name:
- 2-Chloroacetophenone
- Synonyms
- CN;PHENACYL CHLORIDE;1-Chloroacetophenone;phenacyl;2-CHLORO-1-PHENYLETHANONE;A-CHLOROACETOPHENONE;ALPHA-CHLOROACETOPHENONE;cn[qr];teargas;caf[qr]
- CBNumber:
- CB9387386
- Molecular Formula:
- C8H7ClO
- Molecular Weight:
- 154.59
- MDL Number:
- MFCD00000933
- MOL File:
- 532-27-4.mol
- MSDS File:
- SDS
| Melting point | 54-56 °C(lit.) |
|---|---|
| Boiling point | 244-245 °C(lit.) |
| Density | 1.324 g/mL at 25 °C(lit.) |
| vapor pressure | 4 at 20 °C, 14 at 30 °C (quoted, Verschueren, 1983) |
| refractive index | 1.5438 |
| Flash point | 118°C |
| solubility | Soluble in acetone (Weast, 1986). Freely soluble in alcohol, benzene, and ether (Windholz et al., 1983) |
| form | Colorless crystals |
| Water Solubility | insoluble. <0.1 g/100 mL at 19 ºC |
| Sensitive | Moisture Sensitive |
| Merck | 14,2115 |
| BRN | 507950 |
| Exposure limits | NIOSH REL: TWA 0.3 mg/m3 (0.05 ppm), IDLH 15 mg/m3; OSHA PEL: TWA 0.05 ppm (0.3 mg/m3); ACGIH TLV: TWA 0.05 ppm (adopted). |
| Stability | May decompose upon exposure to air or water. Incompatible with bases, amines, alcohols. |
| InChIKey | IMACFCSSMIZSPP-UHFFFAOYSA-N |
| LogP | 1.724 (est) |
| CAS DataBase Reference | 532-27-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 88B5039IQG |
| NIST Chemistry Reference | Ethanone, 2-chloro-1-phenyl-(532-27-4) |
| EPA Substance Registry System | 2-Chloroacetophenone (532-27-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311+H331-H315-H318-H334-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38-42/43-23/25-36-23/24/25 | |||||||||
| Safety Statements | 22-26-36/37/39-45-28A-7/9 | |||||||||
| RIDADR | UN 1693 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AM6300000 | |||||||||
| F | 9-19 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 in rats (mg/kg): 41 i.v., 36 i.p., 127 orally; LC50 in rats: 8750 mg/min/m3 (Ballantyne, Swanston) | |||||||||
| IDLA | 15 mg/m3 | |||||||||
| NFPA 704 |
|
2-Chloroacetophenone price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 77460 | 2-Chloroacetophenone purum, ≥98.0% (GC) | 532-27-4 | 100g | $79.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 77460 | 2-Chloroacetophenone purum, ≥98.0% (GC) | 532-27-4 | 500g | $355 | 2024-03-01 | Buy |
| Alfa Aesar | A10749 | 2-Chloroacetophenone, 98% | 532-27-4 | 100g | $66.4 | 2023-06-20 | Buy |
| Alfa Aesar | A10749 | 2-Chloroacetophenone, 98% | 532-27-4 | 500g | $262 | 2023-06-20 | Buy |
| Sigma-Aldrich | C19686 | 2-Chloroacetophenone 98% | 532-27-4 | 100g | $92.7 | 2024-03-01 | Buy |
2-Chloroacetophenone Chemical Properties,Uses,Production
Description
Chloroacetophenone is contained in tear gases (lacrimators). This substance has an important irritative potential but can also be a sensitizer.
Chemical Properties
2-Chloroacetophenone (CN) is a combustible, colorless-to-gray solid. CN has a sharp, irritating odor, has been described as smelling like “apple blossoms.” It may be dissolved in a solvent
Physical properties
Colorless to gray crystalline solid with a sharp, penetrating, irritating odor. The low odor and high odor threshold concentrations were 102 and 150 μg/m3, respectively (Ruth, 1986).
Uses
Chemical warfare agent (CN); principal constituent in riot control agent Mace; in tear gas formulations for personal protection devices
Uses
2-Chloroacetophenone is used as a nonlethal or less-than-lethal chemical in riot control situations to distract, deter, incapacitate, disorient, or disable disorderly people; to clear facilities or areas; to deny areas; or for hostage rescue. It can also be used in peacekeeping operations. It is also used in military training as a confidence builder for the protective mask.
Uses
Riot control agent.
Definition
A strong lachrymator.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 2032, 1984 DOI: 10.1021/jo00185a046
Tetrahedron, 51, p. 703, 1995 DOI: 10.1016/0040-4020(94)00989-8
Tetrahedron Letters, 13, p. 4661, 1972
General Description
2-chloroacetophenone appears as a white crystalline solid. Denser than water and insoluble in water. Hence sinks in water. A lachrymator: vapors are very irritating to the eyes. Has a floral odor. Used as a riot control agent.
Hazard
The main uses for 2-chloroacetophenone are in tear gas and in chemical Mace. It is a potent eye, throat, and skin irritant. Acute (short-term) inhalation exposure of humans causes burning of the eyes with lacrimation, some degree of blurred vision, possible corneal damage, irritation and burning of the nose, throat, and skin, and burning in the chest with dyspnea. Acute dermal exposure is irritating and can result in first, second, and third degree chemical burns in humans. Squamous hyperplasia of the nasal respiratory epithelium was reported in rats chronically exposed (long-term) via inhalation. EPA has not classified 2-chloroacetophenone with respect to potential carcinogenicity.
Health Hazard
Median lethal dose (mg-min/m3): 11000 (estimated). Median incapacitating dose: 80. Eye/skin toxicity: Temporarily severe eye irritation; mild skin irritation. Rate of action: Instantaneous. Physiological action: Powerfully lacrimatory. Detoxification rate: Rapid. (ANSER)
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Contact allergens
w-Chloroacetophenone is contained in tear gases (lacrimators). This substance has important irritative potential, but can also be a sensitizer.
Safety Profile
A human poison by inhalation. An experimental poison by ingestion, inhalation, intraperitoneal, and intravenous routes. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, and unspecified eye effects, cough, and dyspnea. A severe eye and moderate skin irritant. Questionable carcinogen with experimental neoplastigenic data by skin contact. A riot control agent. When heated to decomposition it emits toxic fumes of Cl-. See also KETONES.
Potential Exposure
Chloroacetophenone is used as a chemical warfare agent (Agent CN) and as a principal ingredient in the riot control agent Mace. It is also used as a pharmaceutical intermediate. The United States considers agent CN and its mixtures with various chemicals to be obsolete for military deployment.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin,remove contaminated clothing and wash immediately withsoap and water. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility. Whenthis chemical has been swallowed, get medical attention.Give large quantities of water and induce vomiting. Do notmake an unconscious person vomit. Medical observation isrecommended for 24-48 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonaryedema, a doctor or authorized paramedic may consideradministering a corticosteroid spray.
Environmental Fate
Chemical/Physical. Releases toxic chloride fumes when heated to decomposition (Sax and Lewis, 1987).
storage
Color Code—Blue: Health Hazard: Store in asecure poison location. Prior to working with this chemicalyou should be trained on its proper handling and storage.Store in tightly closed containers in a refrigerator or cool,well-ventilated area away from oxidizers, heat, water, andsteam. Metal containers involving the transfer of this chemical should be grounded and bonded. Drums must beequipped with self-closing valves, pressure vacuum bungs,and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofthis chemical. Sources of ignition, such as smoking andopen flames, are prohibited where this chemical is used,handled, or stored in a manner that could create a potentialfire or explosion hazard.
Shipping
UN1697 Chloroacetophenone, solid, (CN), Hazard Class: 6.1; Labels: 6.1-Poison Inhalation. UN3416 Chloroacetophenone, liquid, (CN), Hazard Class: 6.1;Labels: 6.1-Poisonous materials. Hazard. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.
Purification Methods
Crystallise it from MeOH [Tanner J Org Chem 52 2142 1987]. [Beilstein 7 IV 641.]
Toxicity evaluation
CN has a half-life under aerobic conditions of 672 h and can be
biodegraded in most moist, nutrient-rich soil.
Biodegradation in water is similar to degradation in soil.
Howard et al. (1991) reports the same 672 h half-life for CN in
aerobic surface water. This half-life is extended up to 2688 h for
anaerobic aqueous degradation.
Volatile losses of CN from surface waters can be another
significant process for CN disappearance in water. For instance,
Olajos and Stopford (2004) calculated that CN contamination
in a river would have a half-life of approximately 14 days, while
CN contamination in a lake would have a half-life of approximately
110 days.
Incompatibilities
Keep away from water, steam, strong oxidizers. CN reacts with water, forming hydrochloric acid. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. CN reacts slowly with metals, causing mild corrosion and may evolve flammable hydrogen gas.
Waste Disposal
Tear gas-containing waste is dissolved in an organic solvent and sprayed into an incinerator equipped with an afterburner and alkaline scrubber utilizing reaction with sodium sulfide in an alcoholwater solution. Hydrogen sulfide is liberated and collected by an alkaline scrubber.
2-Chloroacetophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 6452 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9350 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
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View Lastest Price from 2-Chloroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 2-Chloroacetophenone
532-27-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | 2-Chloroacetophenone
532-27-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | 2-Chloroacetophenone
532-27-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Chloroacetophenone
532-27-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Chloroacetophenone
532-27-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Chloroacetophenone
532-27-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd