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CASPASE INHIBITOR3

CASPASE INHIBITOR3 structure

CAS No.: 187389-53-3

Chemical Name:: CASPASE INHIBITOR3

Synonyms: N-BOC-D-FMK;CASPASE INHIBITOR3;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-;inhibit,broad,Boc Asp(OMe) fluoromethyl ketone,Caspase,Fas-induced,Inhibitor,LDH,oxidative,apoptosis,spontaneous,BocAsp(OMe)fluoromethyl ketone,rupture

CBNumber:: CB9390865

Molecular Formula:: C11H18FNO5

Molecular Weight:: 263.26

MDL Number:: MFCD07370667

MOL File:: 187389-53-3.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:11

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CASPASE INHIBITOR3 Properties

Boiling point	383.5±37.0 °C(Predicted)
Density	1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	-20°C
solubility	Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka	10.12±0.46(Predicted)
form	Powder
color	Off-white

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

CASPASE INHIBITOR3 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B2682	Boc-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid	187389-53-3	3mg	$1020	2024-03-01	Buy
Alfa Aesar	J65812	N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone	187389-53-3	5mg	$463.65	2024-03-01	Buy
Cayman Chemical	16118	Boc-D-FMK ≥95%	187389-53-3	500μg	$62	2024-03-01	Buy
Cayman Chemical	16118	Boc-D-FMK ≥95%	187389-53-3	1mg	$96	2024-03-01	Buy
Cayman Chemical	16118	Boc-D-FMK ≥95%	187389-53-3	5mg	$388	2024-03-01	Buy

Product number	Packaging	Price	Buy
B2682	3mg	$1020	Buy
J65812	5mg	$463.65	Buy
16118	500μg	$62	Buy
16118	1mg	$96	Buy
16118	5mg	$388	Buy

CASPASE INHIBITOR3 Chemical Properties,Uses,Production

Uses

N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications.

Uses

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Biochem/physiol Actions

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

CASPASE INHIBITOR3 Preparation Products And Raw materials

Raw materials

Preparation Products

CASPASE INHIBITOR3 Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3716	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	6000	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.	0571-85350119 15888826472	15888826472@163.com	China	2729	58
Hangzhou Beiputai Biopharmaceutical Co., Ltd	0571-85350119 13305819357	bptsales@163.com	China	3577	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Nanjing Bicbiotechnology Co., Ltd	58
Aladdin Scientific	58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.	58
Hangzhou Beiputai Biopharmaceutical Co., Ltd	58
VDM Biochemicals	64

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CASPASE INHIBITOR3 (3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone (S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate N-BOC-D-FMK Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)- Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone inhibit,broad,Boc Asp(OMe) fluoromethyl ketone,Caspase,Fas-induced,Inhibitor,LDH,oxidative,apoptosis,spontaneous,BocAsp(OMe)fluoromethyl ketone,rupture Methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate 187389-53-3 C11H18NO5F Caspase/Related Products Apoptosis