(1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-D3)phenyl]-1,4,6-heptatrien-3-one
- CAS No.
- 1335198-02-1
- Chemical Name:
- (1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-D3)phenyl]-1,4,6-heptatrien-3-one
- Synonyms
- (1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-D3)phenyl]-1,4,6-heptatrien-3-one
- CBNumber:
- CB93960926
- Molecular Formula:
- C21H20O6
- Molecular Weight:
- 368.39
- MDL Number:
- MOL File:
- 1335198-02-1.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332-H315-H319 | |||||||||
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
NFPA 704 |
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(1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-D3)phenyl]-1,4,6-heptatrien-3-one price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 25438 | Curcumin-d6 ≥99% deuterated forms (d1-d6) | 1335198-02-1 | 500μg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 25438 | Curcumin-d6 ≥99% deuterated forms (d1-d6) | 1335198-02-1 | 1mg | $152 | 2024-03-01 | Buy |
Cayman Chemical | 25438 | Curcumin-d6 ≥99% deuterated forms (d1-d6) | 1335198-02-1 | 5mg | $336 | 2024-03-01 | Buy |
AK Scientific | 0353EB | (1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(trideuteriomethoxy)phenyl]hepta-1,4,6-trien-3-one | 1335198-02-1 | 100mg | $863 | 2021-12-16 | Buy |
aablocks | AA01DF26 | (1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-d3)phenyl]-1,4,6-heptatrien-3-one ≥99%deuteratedforms(d1-d6) | 1335198-02-1 | 5mg | $395 | 2021-12-16 | Buy |
(1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-D3)phenyl]-1,4,6-heptatrien-3-one Chemical Properties,Uses,Production
Description
Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.1,2,3,4 It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.1 Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.2 In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; ) in mouse skin.3 Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.4
References
1. Brouet, I., and Ohshima, H. Curcumin, an anti-
2. Zhang, N., Li, H., Jia, J., et al. Anti-
3. Conney, A.H., Lysz, T., Ferraro, T., et al. Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin Adv. Enzyme Regul. 31,385-396(1991).
4. Tanaka, T., Makita, H., Ohnishi, M., et al. Chemoprevention of 4-
(1E,4Z,6E)-5-Hydroxy-1,7-bis[4-hydroxy-3-(methoxy-D3)phenyl]-1,4,6-heptatrien-3-one Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19536 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7979 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8732 | 58 |
Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | syeu@accelachem.com | China | 11710 | 58 |