ChemicalBook >> CAS DataBase List >>alpha-Lobeline hydrochloride
alpha-Lobeline hydrochloride
- CAS No.
- 134-63-4
- Chemical Name:
- alpha-Lobeline hydrochloride
- Synonyms
- Lobelin Hydrochlorde;LOBELINE HYDROCHLORIDE;(-)-id;a-Lobeline;A-LOBELINE HCL;LOBELINE HCL, A-;(-)-LOBELINE HCL;Einecs 205-150-2;ALPHA-LOBELIN HCL;Lobeline HCl salt
- CBNumber:
- CB9404885
- Molecular Formula:
- C22H28ClNO2
- Molecular Weight:
- 373.92
- MDL Number:
- MFCD00082455
- MOL File:
- 134-63-4.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:01
| Melting point | 183-185 °C (dec.)(lit.) |
|---|---|
| alpha | D20 -43° (c = 2) |
| refractive index | -57.5 ° (C=1, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 25 mg/mL |
| form | powder |
| color | white to off-white |
| optical activity | [α]20/D 56.8°, c = 2 in H2O |
| Merck | 14,5551 |
| BRN | 3920196 |
| LogP | 3.610 (est) |
| CAS DataBase Reference | 134-63-4(CAS DataBase Reference) |
| FDA UNII | 96J834CB88 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331 | |||||||||
| Precautionary statements | P301+P310+P330-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 1544 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OJ8490100 | |||||||||
| F | 8 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
alpha-Lobeline hydrochloride price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000112 | Lobeline hydrochloride European Pharmacopoeia (EP) Reference Standard | 134-63-4 | y0000112 | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | 141879 | (?)-Lobeline hydrochloride 98% | 134-63-4 | 1g | $304 | 2024-03-01 | Buy |
| Cayman Chemical | 29526 | (–)-Lobelin (hydrochloride) | 134-63-4 | 250mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 29526 | (–)-Lobelin (hydrochloride) | 134-63-4 | 500mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 29526 | (–)-Lobelin (hydrochloride) | 134-63-4 | 1g | $143 | 2024-03-01 | Buy |
alpha-Lobeline hydrochloride Chemical Properties,Uses,Production
Description
(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (Ki = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.
Chemical Properties
White to Off-White Solid
Uses
A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.
Uses
A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant
Biological Activity
High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.
in vitro
clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]
in vivo
male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]
Synthesis of alpha-Lobeline hydrochloride from Ethanone, 2-[(6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-
alpha-Lobeline hydrochloride Preparation Products And Raw materials
Global( 227)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from alpha-Lobeline hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-31 | Lobeline hydrochloride
134-63-4
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99%min | 5000 | Wuhan Monad Medicine Tech Co.,LTD | |
 |
2021-07-29 | alpha-Lobeline hydrochloride USP/EP/BP
134-63-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-01-10 | alpha-Lobeline hydrochloride
134-63-4
|
US $1.00 / KG | 1g | 98% | 200kgs | Career Henan Chemical Co |
-
- Lobeline hydrochloride
134-63-4
- US $10.00 / Kg/Bag
- 99%min
- Wuhan Monad Medicine Tech Co.,LTD
-
- alpha-Lobeline hydrochloride USP/EP/BP
134-63-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- alpha-Lobeline hydrochloride
134-63-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
134-63-4(alpha-Lobeline hydrochloride)Related Search:
2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL
2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE
2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride
[2-[(2R,6S)-6-[(2S)-2-HYDROXYPHENETHYL]]-1-METHYL-2-PIPERIDYL]ACETOPHENONE HYDROCHLORIDE
(-)-LOBELINE HCL
LOBELINE HCL, A-
(-)-LOBELINE HYDROCHLORIDE
L-LOBELINE HYDROCHLORIDE
A-LOBELINE HCL
A-LOBELINE, HYDROCHLORIDE
ALPHA-LOBELINE HYDROCHLORIDE
ALPHA-LOBELIN HCL
2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride
2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride
a-Lobeline
Lobeline HCl salt
Apolipoprotein B (LDL), Sheep anti-Human, Guinea pig, Swine (NO X w/Bovine, Horse, Dog, Cat, Rabbit, Chicken, Goat, Mouse, Rat)
2-[6-(beta-Hydroxyphenylethyl)-1-methyl-2-piperidinyl]acetophenone hydrochloride
Acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, hydrochloride, (-)-
Einecs 205-150-2
Ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride
Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride, (2R-(2alpha,6alpha(S*))-
α-Lobeline Hydrochcloride
2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenonehydrochloride
Lobeline hydrochloride ,99%
α-Lobeline hydrochloride,2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride, ()-Lobeline hydrochloride
2-[1-chloro-6-(2-hydroxy-2-phenylethyl)-1-Methyl-1$l^{5}-piperidin-2-yl]-1-phenylethan-1-one
2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-Methyl-2-piperidinyl]-1-phenylethanone
Hydrochloride
2-[6-(2-hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
(-)-Lobeline hydrochloride, 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride
α-Lobeline hydrochloride, L-Lobeline hydrochloride
2-(6-(2-Hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl)-1-phenylethanone hydrochloride
(-)-id
2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor
2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone
Lobelinhydrochloride
2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone
2-[(6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenylethanone
a-Lobeline Hydrochloride (L-Lobeline hydrochloride
Lobeline hydrochloride CRS
2-((2R,6S)-6-((S)-2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one hydrochloride
alpha-Lobeline hydrochloride USP/EP/BP
(-)-a-Lobeline Hydrochloride
Lobeline hydrochloride (C-07475)
α-Lobeline hydrochloride
Lobelinehydrochlonide
LOBELINE HYDROCHLORIDE
Lobelin Hydrochlorde
α-Lobeline Hydrochcloride
(-)-Lobeline hydrochloride
(–)-Lobelin (hydrochloride)
2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride
(?)-Lobeline hydrochloride
134-63-4
C22H27NO2HCl
Building Blocks
Asymmetric Synthesis
Chiral Building Blocks