(R)-2-PHENYLPIPERIDINE
- CAS No.
- 58613-54-0
- Chemical Name:
- (R)-2-PHENYLPIPERIDINE
- Synonyms
- (R)-2-PHENYLPIPERIDINE;(2R)-2-phenylpiperidine;(R)-(+)-6-phenylpiperidine;(R)-2-Phenylpiperidine 95%;Piperidine, 2-phenyl-, (2R)-
- CBNumber:
- CB9407604
- Molecular Formula:
- C11H15N
- Molecular Weight:
- 161.24
- MDL Number:
- MFCD06762593
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
(R)-2-PHENYLPIPERIDINE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 900573 | (R)-2-Phenylpiperidine 95% | 58613-54-0 | 1G | $697 | 2023-06-20 | Buy |
| Sigma-Aldrich | 900573 | (R)-2-Phenylpiperidine 95% | 58613-54-0 | 5G | $1020 | 2023-01-07 | Buy |
| TRC | P400183 | (R)-2-Phenylpiperidine | 58613-54-0 | 100mg | $350 | 2021-12-16 | Buy |
| Matrix Scientific | 121952 | (R)-2-Phenylpiperidine >97% | 58613-54-0 | 500mg | $441 | 2021-12-16 | Buy |
| Activate Scientific | AS116333 | (R)-2-Phenylpiperidine 97+% ee | 58613-54-0 | 1g | $478 | 2021-12-16 | Buy |
(R)-2-PHENYLPIPERIDINE Chemical Properties,Uses,Production
Description
(R)-2-Phenylpiperidine is an alkene that has been used in the desymmetrization of secondary amides to produce enantiopure products. It has been shown to be stereoselective. It could prepared from δ-Amino β-keto esters 3. The kinetic resolution of this compound is due to the formation of an enamine, which undergoes a 1,4-addition reaction with an aldoxime or piperidone.
Uses
Chiral building block developed using Liverpool ChiroChem-patented technology.
Synthesis
In a 10 mL one-necked round-bottomed flask equipped with a magnetic stir bar, rubber septum, and argon balloon was placed 0.033 g (0.19 mmol, 1 equiv.) of (R)-(+)-6-Phenylpiperidin-2-one and THF (1.2 mL). Lithium aluminum hydride (0.95 mL, 1.0 M solution in THF, 0.95 mmol) was added slowly via syringe and the reaction mixture was stirred at rt for 8 h. The solution was cooled to 0 °C, sat. Na2SO4 (0.17 mL) was added, stirred for 0.5 h at rt and the reaction mixture was filtered through Celite. The organic phases were concentrated and flash chromatography (7% MeOH/CH2Cl2) gave 0.025 g (82%) of (R)-2-phenylpiperidine as volatile oil.
(R)-2-PHENYLPIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
| Tianjin Xinghan Biotechnology Co., Ltd | +8618698089028 | 1725517238@qq.com | China | 2479 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | sales@capotchem.com | China | 18217 | 66 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2607 | 58 |