cis-1,2-Diaminocyclohexane
- CAS No.
- 1436-59-5
- Chemical Name:
- cis-1,2-Diaminocyclohexane
- Synonyms
- (2-aminocyclohexyl)amine;cis-1,2-Cyclohexandiamine;CIS-1,2-CYCLOHEXANEDIAMINE;CIS-1,2-DIAMINOCYCLOHEXANE;meso-1,2-Cyclohexanediamine;cis-Cyclohexane-1,2-diamine;1,2-DIAMINOCYCLOHEXANE, cis;1,2-Cyclohexanediamine, cis-;(R)(S)-1,2-Diaminocyclohexane;(1R,2S)-1,2-Cyclohexanediamine
- CBNumber:
- CB9412187
- Molecular Formula:
- C6H14N2
- Molecular Weight:
- 114.19
- MDL Number:
- MFCD00063746
- MOL File:
- 1436-59-5.mol
| Melting point | 8°C |
|---|---|
| Boiling point | 92-93 °C/18 mmHg (lit.) |
| Density | 0.952 g/mL at 25 °C (lit.) |
| vapor pressure | 0.4 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 161 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| Water Solubility | Completely miscible in water |
| pka | 9.93(at 20℃) |
| form | Low Melting Solid |
| color | Brown |
| InChIKey | SSJXIUAHEKJCMH-OLQVQODUSA-N |
| CAS DataBase Reference | 1436-59-5(CAS DataBase Reference) |
| FDA UNII | R0ZN6K26EP |
| NIST Chemistry Reference | cis-1,2-Cyclohexanediamine(1436-59-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2735 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29213000 | |||||||||
| NFPA 704 |
|
cis-1,2-Diaminocyclohexane price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1463 | cis-1,2-Cyclohexanediamine >97.0%(GC)(T) | 1436-59-5 | 5g | $72 | 2024-03-01 | Buy |
| TCI Chemical | C1463 | cis-1,2-Cyclohexanediamine >97.0%(GC)(T) | 1436-59-5 | 25g | $210 | 2024-03-01 | Buy |
| TRC | D416224 | cis-1,2-Diaminocyclohexane | 1436-59-5 | 100mg | $45 | 2021-12-16 | Buy |
| TRC | D416224 | cis-1,2-Diaminocyclohexane | 1436-59-5 | 500mg | $55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014089 | CIS-1, 2-DIAMINO CYCLOHEXANE 95.00% | 1436-59-5 | 1G | $686.54 | 2021-12-16 | Buy |
cis-1,2-Diaminocyclohexane Chemical Properties,Uses,Production
Description
cis-1, 2-Diaminocyclohexane is a cyclohexane derivative. It can be used for the synthesis of platinum complexes with high antitumor activity. It can also be used for the preparation of multidentate ligands for uranyl and transition metal complexation. Moreover, it can also be used as the base for the manufacturing of titanium salalen catalyst. Its derivative also has the potential to be manufactured into a potent factor Xa inhibitor.
References
Khokhar, Abdul R., et al. "Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes." Journal of Medicinal Chemistry 40.1(1997):112.
Mauldin, S. K., et al. "High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand. " Analytical Biochemistry157.1 (1986):129-43.
Berkessel, A, et al. "Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: enantioselective epoxidation of terminal non-conjugated olefins with H2O2. " Angewandte Chemie 52.32(2013):8467-71.
Yoshikawa, K, et al. "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. " Bioorganic & Medicinal Chemistry 17.24(2009):8221.
http://www.sigmaaldrich.com/catalog/product/aldrich/307467?lang=en®ion=US
Chemical Properties
Clear colorless liquid
Uses
cis-1,2-Diaminocyclohexane was used in the synthesis of platinum complexes that have high antitumor activity.It was also used in the synthesis of multidentate ligands for uranyl and transition metal complexation.
General Description
cis-1,2-Diaminocyclohexane perturbed the spectrum of free pyrroloquinoline quinone (PQQ), a covalently linked form of which is the carbonyl cofactor of lysyl oxidase and also induced similar changes in the spectrum of lysyl oxidase.
Purification Methods
Dry the diamine over solid KOH and distil it in a vacuum. It is a strong base, keep away from CO2, store in the dark under N2. [Beilstein 13 IV 1.]
cis-1,2-Diaminocyclohexane Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6711 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 724 | 55 | |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from cis-1,2-Diaminocyclohexane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-23 | cis-1,2-Diaminocyclohexane
1436-59-5
|
US $31.00-274.00 / g | 5g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2022-09-19 | (±)-cis-1,2-Diaminocyclohexane
1436-59-5
|
US $20.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-07-13 | cis-1,2-Diaminocyclohexane
1436-59-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- cis-1,2-Diaminocyclohexane
1436-59-5
- US $31.00-274.00 / g
- 0.98
- Shanghai UCHEM Inc.
-
- (±)-cis-1,2-Diaminocyclohexane
1436-59-5
- US $20.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- cis-1,2-Diaminocyclohexane
1436-59-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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