TYRPHOSTIN RG 13022
- CAS No.
- 136831-48-6
- Chemical Name:
- TYRPHOSTIN RG 13022
- Synonyms
- RG-13022;RG13022, >98%;RG13022;RG 13022;TYRPHOSTIN RG 13022;α-(3-Pyridyl)-3,4-dimethoxybenzeneacrylonitrile;ALPHA-(3'-PYRIDYL)-(3,4-DIMETHOXY)CINNAMONITRILE;3-(3,4-Dimethoxyphenyl)-2-(3-pyridinyl)propenenitrile;3-(3,4-dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile;2-(3,4'-DIMETHOXYPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE;3-Pyridineacetonitrile,a-[(3,4-dimethoxyphenyl)methylene]-
- CBNumber:
- CB9417056
- Molecular Formula:
- C16H14N2O2
- Molecular Weight:
- 266.29
- MDL Number:
- MFCD00236444
- MOL File:
- 136831-48-6.mol
| Melting point | 116.0 to 120.0 °C |
|---|---|
| Boiling point | 423.8±45.0 °C(Predicted) |
| Density | 1.172±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO or ethanol: soluble |
| pka | 3.03±0.12(Predicted) |
| form | White solid. |
| color | White to Yellow to Green |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2933.39.9200 |
TYRPHOSTIN RG 13022 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T6568 | Tyrphostin RG 13022 ≥98% | 136831-48-6 | 1mg | $62.3 | 2022-05-15 | Buy |
| Sigma-Aldrich | T6568 | Tyrphostin RG 13022 ≥98% | 136831-48-6 | 5mg | $216 | 2022-05-15 | Buy |
| TCI Chemical | T3575 | Tyrphostin RG 13022 >98.0%(GC) | 136831-48-6 | 25mg | $176 | 2024-03-01 | Buy |
| TCI Chemical | T3575 | Tyrphostin RG 13022 >98.0%(GC) | 136831-48-6 | 100mg | $524 | 2024-03-01 | Buy |
| TRC | R314713 | RG-13022 | 136831-48-6 | 5mg | $75 | 2021-12-16 | Buy |
TYRPHOSTIN RG 13022 Chemical Properties,Uses,Production
Uses
RG-13022 is an epidermal growth factor (EGF) inhibitor and PDGF receptor tyrosine kinases.
Biological Activity
rg13022 is a egfr tyrosine kinase inhibitor.increased expression of various growth factor receptors including egfr has been observed in human tumours. one therapeutic strategy for overcoming egf autocrine control of tumour growth is to inhibit egfr protein tyrosine kinase.
in vitro
rg13022 had a dose-dependent, antiproliferative effect on gastric cell lines when grown either in serum-free conditions or in the presence of fcs. western blotting showed that rg13022 treatment led to an inhibition of the egfr phosphorylation in a431 cells and both egfr and c-erbb-2 in mkn45 cells. furthermore, investigation of intracellular signalling pathways suggested that alterations in intracellular signalling were responsible for the actions of rg 13022 in these cells [1].
in vivo
in rats, rg13022 showed rapid bi-exponential elimination from plasma with a terminal half-life of 50.4 min. rg13022 plasma concentrations were less than 1 μm by 20 min after injection. in addition, rg13022 had no influence on the growth of hn5 tumours when administered chronically, starting either on the tumour inoculation day or after establishment of tumour xenografts. the rapid in-vivo elimination of rg13022 had potential significance to its development, as plasma concentrations fell below that required for in-vitro activity by 20 min after injection [2].
IC 50
5 μm for egfr
References
[1] mclaughlin m,brunton v,morrison v,rae a,cooke t,bartlett j. growth inhibition of gastric cancer cell lines by the tyrphostin rg13022 and its effects on intracellular signalling. int j oncol.1996 mar;8(3):589-96.
[2] mcleod hl,brunton vg,eckardt n,lear mj,robins dj,workman p,graham ma. in vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor rg13022. br j cancer.1996 dec;74(11):1714-8.
TYRPHOSTIN RG 13022 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |