Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CRT0066101 Hydrochloride

CRT0066101 Hydrochloride

CRT0066101 Hydrochloride Structure
CRT0066101 Hydrochloride structure
CAS No.
1781742-22-0
Chemical Name:
CRT0066101 Hydrochloride
Synonyms
2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol, trihydrochloride
CBNumber:
CB94199062
Molecular Formula:
C18H23ClN6O
Molecular Weight:
374.87
MDL Number:
MFCD28044320
MOL File:
1781742-22-0.mol
Last updated:2023-06-08 09:02:15
Request For Quotation

CRT0066101 Hydrochloride Properties

solubility DMF: 0.1 mg/ml; DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Water: 10 mg/ml
form A crystalline solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

CRT0066101 Hydrochloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15337 CRT0066101 (hydrochloride) 1781742-22-0 5mg $100 2024-03-01 Buy
Cayman Chemical 15337 CRT0066101 (hydrochloride) 1781742-22-0 10mg $183 2024-03-01 Buy
Cayman Chemical 15337 CRT0066101 (hydrochloride) 1781742-22-0 1mg $34 2024-03-01 Buy
AK Scientific 8391EM CRT0066101Hydrochloride 1781742-22-0 10mg $301 2021-12-16 Buy
Product number Packaging Price Buy
15337 5mg $100 Buy
15337 10mg $183 Buy
15337 1mg $34 Buy
8391EM 10mg $301 Buy

CRT0066101 Hydrochloride Chemical Properties,Uses,Production

Description

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively).1 It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl.1 It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.1

References

1. Harikumar, K.B., Kunnumakkara, A.B., Ochi, N., et al. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo Mol. Cancer Ther. 9(5),1136-1146(2010).

CRT0066101 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

CRT0066101 Hydrochloride Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 58
2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol, trihydrochloride 1781742-22-0