OLEYLHYDROXAMIC ACID
- CAS No.
- 10335-69-0
- Chemical Name:
- OLEYLHYDROXAMIC ACID
- Synonyms
- Einecs 233-728-4;N-hydroxyoleamide;N-Hydroxyoleylamide;N-Hydroxyoleic amide;OLEYLHYDROXAMIC ACID;Oleoylhydroxamic acid;N-Hydroxy-9-octadecenamide;(Z)-N-Hydroxy-9-octadecenamide;(9Z)-9-Octadecenehydroxamic acid;9-Octadecenamide, N-hydroxy-, (9Z)-
- CBNumber:
- CB9421385
- Molecular Formula:
- C18H35NO2
- Molecular Weight:
- 297.48
- MDL Number:
- MFCD02683956
- MOL File:
- 10335-69-0.mol
| Melting point | 61 °C |
|---|---|
| Density | 0.921±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 9.48±0.20(Predicted) |
| EPA Substance Registry System | N-Hydroxyoleylamide (10335-69-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319-H413 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
OLEYLHYDROXAMIC ACID price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19644 | MMP-2 Inhibitor I ≥98% | 10335-69-0 | 5mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 19644 | MMP-2 Inhibitor I ≥98% | 10335-69-0 | 10mg | $96 | 2024-03-01 | Buy |
| ApexBio Technology | C5615 | MMP-2InhibitorI | 10335-69-0 | 10mg | $108 | 2021-12-16 | Buy |
| ApexBio Technology | C5615 | MMP-2InhibitorI | 10335-69-0 | 5mg | $71 | 2021-12-16 | Buy |
OLEYLHYDROXAMIC ACID Chemical Properties,Uses,Production
Biological Activity
mmp-2 inhibitor i, a hydroxamate-based, long-chain fatty acid, is a reversible inhibitor of matrix metalloproteinase (mmp)-2.matrix metalloproteinases (mmps) have been involved in the degradation of extracellular matrix. mmps contribute to long-term remodeling processes such as embryogenesis, tumor invasion, inflammation, angiogenesis, and wound healing. mmp-2, also known as gelatinase a or type iv collagenase, has been involved in regulating diverse cellular functions independent of its action on the extracellular matrix, including vascular tone, platelet aggregation, and mediation of the acute mechanical dysfunction of the heart immediately after ischemia and reperfusion [2]. up-regulation of mmp-2 has been associated with tumor invasion and metastasis [3].mmp-2 inhibitor i inhibited the activity of matrix metalloproteinase (mmp)-2 with the ki value of 1.6 μm [1]. mmp-2 inhibitor i attenuated cancer cell migration [3]. mmp-2 inhibitor i had also been used to preserve blood-brain barrier function in a wistar rat model of pneumococcal meningitis [4].
References
[1] berton a, rigot v, huet e, et al. involvement of fibronectin type ii repeats in the efficient inhibition of gelatinases a and b by long-chain unsaturated fatty acids[j]. journal of biological chemistry, 2001, 276(23): 20458-20465.
[2] wang w, schulze c j, suarez-pinzon w l, et al. intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury[j]. circulation, 2002, 106(12): 1543-1549.
[3] emmert-buck m r, roth m j, zhuang z, et al. increased gelatinase a (mmp-2) and cathepsin b activity in invasive tumor regions of human colon cancer samples[j]. the american journal of pathology, 1994, 145(6): 1285.
[4] barichello t, generoso j s, michelon c m, et al. inhibition of matrix metalloproteinases-2 and-9 prevents cognitive impairment induced by pneumococcal meningitis in wistar rats[j]. experimental biology and medicine, 2014, 239(2): 225-231.
OLEYLHYDROXAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
OLEYLHYDROXAMIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Tianmen Hengchang Chemical Co., Ltd | 027-59322316 15172518801 | 1208480077@qq.com | China | 9946 | 58 |
| Hubei Qifei Pharmaceutical Chemical Co., Ltd | 027-027-59322506 18071128681 | 1438082200@qq.com | China | 9995 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10007 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 12345678910 | hanfangpharma@126.com | China | 30968 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |