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DL-LAUDANOSINE

DL-LAUDANOSINE
DL-LAUDANOSINE structure
CAS No.
1699-51-0
Chemical Name:
DL-LAUDANOSINE
Synonyms
DL-LAUDANOSINE;DL-LAUDANOSIDE;(R)-Laudanosine;Laudanosine CRS;(+-)-laudanosine;LAUDANOSINE, DL-;(+/-)-LAUDANOSIDE;DL-Laudanosine,99%;LAUDANOSINE, DL-(SH);Atracurium Impurity 42
CBNumber:
CB9423783
Molecular Formula:
C21H27NO4
Formula Weight:
357.44
MOL File:
1699-51-0.mol

DL-LAUDANOSINE Properties

Melting point:
115°C
Boiling point:
490.07°C (rough estimate)
Density 
1.1729 (rough estimate)
refractive index 
1.5614 (estimate)
pka
7.80±0.40(Predicted)
FDA UNII
DA7R5WVN48
SAFETY
  • Risk and Safety Statements
Risk Statements  26/28-40
Safety Statements  22-24/25
RIDADR  2810
HazardClass  6.1(b)
PackingGroup  III
NFPA 704
0
1 0

DL-LAUDANOSINE price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC L178540 DL-Laudanosine 1699-51-0 100mg $490 2021-12-16 Buy
Biosynth Carbosynth FL52345 DL-Laudanosine 1699-51-0 1 g $500 2021-12-16 Buy
Biosynth Carbosynth FL52345 DL-Laudanosine 1699-51-0 50 mg $80 2021-12-16 Buy
Biosynth Carbosynth FL52345 DL-Laudanosine 1699-51-0 100 mg $130 2021-12-16 Buy
Biosynth Carbosynth FL52345 DL-Laudanosine 1699-51-0 250 mg $200 2021-12-16 Buy

DL-LAUDANOSINE Chemical Properties,Uses,Production

Description

This opium alkaloid occurs in the liquor following precipitation of Thebaine (q.v.) and is purified by extraction with small quantities of Et20, followed by precipitation with potassium iodide. The base crystallizes from hot C6H6 in small, colourless needles and has [α]15D+ 103.23° (EtOH). It is freely soluble in CHCI3, EtOH, Et20 or hot C6H6 but insoluble in H20 or alkalies. No colour is produced with FeCl 3 but with Fe203 and H2S04, a brown colour is formed, changing to green when warmed to ISOoC. With concentrated H2S04 alone, the alkaloid gives a rose-red colour, changing to deep violet at ISO°C. The solution of the alkaloid in EtOH is alkaline to litmus and both it, and its salts, are bitter to the taste. The crystalline methiodide has m.p. 218-221°C; [α]D + 120°. The oxidation products with Mn02 and H2S04 are veratraldehyde, 2:3:6:7- tetramethoxy-9: I O-dihydroanthracene and laudaline (4: S-dimethoxy-2: - methylaminoethylbenzaldehyde, m.p. 123-4°C. On exhaustive methylation it yields trimethylamine and laudanosene (tetramethoxy-o-vinylstilbene). Laudanosine is one of the most convulsant of the opium alkaloids but possesses only a slight analgesic action.

Chemical Properties

light yellow fine crystalline powder

Purification Methods

Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and

References

Pictet, Athanasescu., Ber., 33, 2347 (1900)
Pictet, Finkelstein., ibid, 42, 1979 (1909)
Pyman, Reynolds.,J. Chern. Soc., 97, 1324 (1910)
Kondo, Mori.,J. Ph arm. Soc., Japan, 51,615 (1931)
Craig, Tarbell., J. Amer. Chern. Soc., 70,2783 (1948)
Synthesis:
Pictet, Finkelstein., Compt. rend., 148,925 (1909)
Elliot.,J. Heterocycl. Chern., 7, 1229 (1970)
Pharmacology:
Zunz., Elements de Pharmacodynamie speciale, Tome I, 178, Masson & Co., Paris (1932)
Krueger, Eddy, Sumwalt., U.S. Public Health Reports, Suppl. 165, 1007 (1943)

DL-LAUDANOSINE Preparation Products And Raw materials

Raw materials

Preparation Products


DL-LAUDANOSINE Suppliers

Global( 66)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58
Alfa Chemistry
+1-516-662-5404
1-516-927-0118 inquiry@alfa-chemistry.com United States 10563 58
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-18621169078 +86-021-61259100
86-21-61259102 int02@meryer.com China 40264 62
S.Z. PhyStandard Bio-Tech. Co., Ltd. 13380397412
0755 28094224 3001280422@qq.com;marketing@phystandard.com China 4840 50
ChemStrong Scientific Co.,Ltd 15920483169 0755-66853366
sales@chem-strong.com China 26481 56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 17798518460 025-66099280
sales01@aikonchem.com China 16689 50

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