Fmoc-OSu
- CAS No.
- 82911-69-1
- Chemical Name:
- Fmoc-OSu
- Synonyms
- FMOC-OSU;Fomc-Osu;(9H-Fluoren-9-yl)Methyl (2,5-dioxopyrrolidin-1-yl) carbonate;FMOC N-HYDROXYSUCCINIMIDE ESTER;FMOC-SU;FMOC-ONSU;9-FLUORENYLMETHYL SUCCINIMIDYL CARBONATE;FMOC-Succinimide;9-fluorenylmethyl-n-succinimide carbonate;9-FLUORENYLMETHYL N-SUCCINIMIDYL CARBONATE
- CBNumber:
- CB9428667
- Molecular Formula:
- C19H15NO5
- Molecular Weight:
- 337.33
- MDL Number:
- MFCD00010733
- MOL File:
- 82911-69-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Fmoc-OSu Novabiochem? | 8.51014 | 25g | $137 |
| Fmoc-OSu Novabiochem? | 8.51014 | 100g | $414 |
| Fmoc-OSu Novabiochem® | 8.51014 | 1 kg | $2580 |
| Fmoc-OSu Novabiochem® | 8.51014 | 1 kg | $2580 |
| Fmoc N-hydroxysuccinimide ester ≥98.0% (HPLC) | 46920 | 5G | $93.4 |
| More product size | |||
| Melting point | 150-153 °C(lit.) |
|---|---|
| Boiling point | 150-153°C |
| Density | 1.3460 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in dimethyl sulfoxide and dimethyl formamide. |
| form | Microfine Powder |
| color | White or almost white |
| Sensitive | Moisture Sensitive |
| BRN | 3569540 |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2 |
| InChIKey | WMSUFWLPZLCIHP-UHFFFAOYSA-N |
| SMILES | C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)ON1C(=O)CCC1=O |
| CAS DataBase Reference | 82911-69-1(CAS DataBase Reference) |
| FDA UNII | AD7AUS3GKT |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H411 | |||||||||
| Precautionary statements | P261-P264-P273-P280-P301+P312-P302+P352 | |||||||||
| Hazard Codes | Xi,N,Xn | |||||||||
| Risk Statements | 36/37/38-51/53-43-22 | |||||||||
| Safety Statements | 22-24/25-26/37/39-26-61-37-24 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Moisture Sensitive | |||||||||
| HazardClass | 9 | |||||||||
| HS Code | 29251995 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Fmoc-OSu price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.51014 | Fmoc-OSu Novabiochem? | 82911-69-1 | 25g | $137 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.51014 | Fmoc-OSu Novabiochem? | 82911-69-1 | 100g | $414 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.51014 | Fmoc-OSu Novabiochem® | 82911-69-1 | 1 kg | $2580 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.51014 | Fmoc-OSu Novabiochem® | 82911-69-1 | 1 kg | $2580 | 2025-07-31 | Buy |
| Sigma-Aldrich | 46920 | Fmoc N-hydroxysuccinimide ester ≥98.0% (HPLC) | 82911-69-1 | 5G | $93.4 | 2025-07-31 | Buy |
Fmoc-OSu Chemical Properties,Uses,Production
Description
Fmoc-OSu (N-(9-Fluorenylmethoxycarbonyloxy)succinimide) is a reagent used in solid-phase peptide synthesis (SPPS) for Fmoc protection of amino groups, particularly amino acids. This reagent contains an Fmoc functional group, which is stable under acidic conditions and cleaves under alkaline conditions. Fmoc-OSu reacts with amino groups to form stable amide bonds, helping to reduce the occurrence of side reactions. Additionally, Fmoc-OSu can also be used as a fluorescent reagent.
Chemical Properties
White powder
Uses
N-(9-Fluorenylmethoxycarbonyloxy)succinimide is used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.
Uses
Reagent for the preparation of pure Fmoc amino acids free from contamination by Fmoc-dipeptides.
Uses
N-protecting reagent for oligonucleotide and peptide syntheses
Mechanism of action
The protective mechanism of Fmoc-OSu involves the amine group (R-NH₂) of the protected molecule acting as a nucleophile and attacking the carbonyl carbon of the Fmoc-OSu molecule, forming a tetrahedral intermediate. where the nitrogen of the amine is now bonded to the carbonyl carbon of the Fmoc group, yielding an Fmoc-protected amine and a succinimide. The Fmoc group is typically removed using bases such as piperidine, which can remove the Fmoc group without hydrolyzing the peptide backbone. In solid-phase peptide synthesis (SPPS), the removal of the Fmoc group occurs via a two-step mechanism: first, the acidic proton at the 9-position of the naphthalene ring system is removed using a mild base (preferably a secondary amine), followed by a β-elimination reaction, generating a highly reactive dibenzofuran (DBF) intermediate, which is immediately captured by the secondary amine to form a stable adduct.
Purification Methods
Recrystallise the carbonate from CHCl3/Et2O, or from pet ether (b 40-60o). [Pauet Can J Chem 60 976 1982, Lapatsaris et al. Synthesis 671 1983.]
Fmoc-OSu Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 458 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +8618917565227 | prisun@prisunpharma.com | China | 215 | 58 |
| Xinxiang Juyuan Biological Technology Co., Ltd. | +8615637360870 | sales@xxkfqchem.com | China | 19 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8768 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3588 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3994 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20134 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
Related articles
- Synthesis and Thermodynamic Study of N-(9-Fluorenylmethoxycarbonyloxy)succinimide
- N - (9 - fluorenylmethoxycarbonyloxy) succinimide is an amino acid derivative reagent, important pharmaceutical intermediate, ....
- Jul 15，2022
View Lastest Price from Fmoc-OSu manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-13 | N-(9-Fluorenylmethoxycarbonyloxy)succinimide
82911-69-1
|
US $0.00-0.00 / kg | 1kg | 99% | 800kg | Wuhan Biocar Pharmacy CO.,Ltd. | |
 |
2025-12-13 | FMOC-OSU
82911-69-1
|
US $650.00 / KG | 1KG | 99 | 50TONS | Xinxiang Juyuan Biological Technology Co., Ltd. | |
 |
2025-12-13 | N-(9-Fluorenylmethoxycarbonyloxy)succinimide
82911-69-1
|
US $10.00 / KG | 1000KG | 99.99% | 10 tons | .GZ HONESTCHEM CO.,LTD |
-
- N-(9-Fluorenylmethoxycarbonyloxy)succinimide
82911-69-1
- US $0.00-0.00 / kg
- 99%
- Wuhan Biocar Pharmacy CO.,Ltd.
-
- FMOC-OSU
82911-69-1
- US $650.00 / KG
- 99
- Xinxiang Juyuan Biological Technology Co., Ltd.
-
- N-(9-Fluorenylmethoxycarbonyloxy)succinimide
82911-69-1
- US $10.00 / KG
- 99.99%
- .GZ HONESTCHEM CO.,LTD
