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1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate structure
CAS No.
56602-33-6
Chemical Name:
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
Synonyms
BOP;BOP REAGENT;cas:56602-33-6;CASTROS REAGENT;CASTRO'S REAGENT;Benzotriazole-1-yl-o;BOP, Castros Reagent;BOP reagent, 99% min.;HEXAFLUOROPHOSPHATE BOP;BOP hexafluorophosphate
CBNumber:
CB9434718
Molecular Formula:
C12H22F6N6OP2
Formula Weight:
442.28
MOL File:
56602-33-6.mol

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Properties

Melting point:
>130 °C (dec.)(lit.)
Flash point:
138°C
storage temp. 
2-8°C
solubility 
methanol: 25 mg/mL, clear
form 
Powder
color 
White to off-white
Water Solubility 
Soluble in methanol, acetone and dichloromethane. Insoluble in water.
Decomposition 
138 ºC
Sensitive 
Moisture & Light Sensitive
BRN 
4287025
CAS DataBase Reference
56602-33-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,E,F
Risk Statements  37/38-44-36/37/38-11-2
Safety Statements  24/25-37/39-36-26-35-36/37/39
RIDADR  UN 1325 4.1/PG 2
WGK Germany  3
8-10-21
Hazard Note  Irritant
HazardClass  4.1
PackingGroup 
HS Code  29339980
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H228 Flammable solid Flammable solids Category 1
Category 2
Danger
Warning
P210, P240,P241, P280, P370+P378
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 226084 (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 97% 56602-33-6 1g $23 2018-11-13 Buy
Sigma-Aldrich 226084 (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 97% 56602-33-6 5g $64.3 2018-11-13 Buy
TCI Chemical B1651 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide] >98.0%(HPLC) 56602-33-6 5g $40 2018-11-22 Buy
TCI Chemical B1651 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide] >98.0%(HPLC) 56602-33-6 25g $165 2018-11-22 Buy
Alfa Aesar A16140 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 98% 56602-33-6 25g $253 2018-11-13 Buy

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

Peptide coupling reagent which suppresses racemization.

Uses

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.

Purification Methods

Dissolve it in CH2Cl2, dry (MgSO4), filter, concentrate it under a vacuum, then add dry Et2O and filter off the first crop. Add CH2Cl2 to the filtrate and concentrate again to obtain a second crop. The solid is washed with dry Et2O and dried in a vacuum. Also recrystallise it from dry Me2CO/Et2O and check the purity by NMR. Store it in the dark. [Castro et al. Synthesis 751 1976, Nguyen et al J Chem Soc, Perkin Trans I 1915 1987, Coste et al. Tetrahedron Lett 36 4253 1995.]

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Preparation Products And Raw materials

Raw materials

Preparation Products


1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Suppliers

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Capot Chemical Co.,Ltd.
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View Lastest Price from 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-15 Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate
56602-33-6
US $1.00 / KG 1KG 99% 20kg career henan chemical co

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate Spectrum


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