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Cephalothin sodium

Cephalothin sodium
Cephalothin sodium structure
CAS No.
58-71-9
Chemical Name:
Cephalothin sodium
Synonyms
38253;Coaxin;Keflin;Seffin;Microtin;Averon 1;Cemastin;Lospoven;synclotin;Cephation
CBNumber:
CB9443527
Molecular Formula:
C16H16N2O6S2.Na
Formula Weight:
418.42
MOL File:
58-71-9.mol

Cephalothin sodium Properties

Melting point:
240°C
alpha 
D +135° (c = 1.0 in water)
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL, clear, faintly yellow
form 
neat
Water Solubility 
158 mg/L
Merck 
13,1994
BRN 
4120706
CAS DataBase Reference
58-71-9(CAS DataBase Reference)
FDA UNII
C22G6EYP8B
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P284-P304+P340-P342+P311-P280g-P342+P311a-P501a-P261a-P284a
Hazard Codes  Xn,Xi
Risk Statements  42/43
Safety Statements  22-36/37
WGK Germany  2
RTECS  XI0388300
HS Code  29419000
Toxicity LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto)

Cephalothin sodium price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4520 Cephalothin sodium salt 96.0-101.0% 58-71-9 1g $115 2021-03-22 Buy
Sigma-Aldrich C0682000 Cefalotin sodium European Pharmacopoeia (EP) Reference Standard 58-71-9 $190 2021-03-22 Buy
Sigma-Aldrich 1102000 Cephalothin sodium United States Pharmacopeia (USP) Reference Standard 58-71-9 200mg $366 2021-03-22 Buy
Alfa Aesar J65607 Cephalothin sodium salt 58-71-9 5g $322 2020-06-24 Buy
Alfa Aesar J65607 Cephalothin sodium salt 58-71-9 1g $92.4 2020-06-24 Buy

Cephalothin sodium Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Originator

Keflin,Lilly,US,1964

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Uses

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics,strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics,and for immunology studies in relation to antibiotics.It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

Manufacturing Process

7-(2'-Thienylacetamido)cephalosporanic acid sodium salt may be produced from 2-thienylacetyl chloride, obtainable by treatment of 2-thienylacetic acid [Ernst, Berichte, 19 (1886) 3281] with thionyl chloride in a conventional manner. The 2-thienylacetyl chloride is then reacted with 7- aminocephalosporanic acid and then converted to the sodium salt using sodium hydroxide.

brand name

Keflin (Lilly); Seffin (GlaxoSmithKline).

Therapeutic Function

Antibacterial

Clinical Use

Cephalothin sodium (Keflin) occurs as a white to off-white,crystalline powder that is practically odorless. It is freelysoluble in water and insoluble in most organic solvents.Although it has been described as a broad-spectrum antibacterialcompound, it is not in the same class as the tetracyclines.Its spectrum of activity is broader than that ofpenicillin G and more similar to that of ampicillin. Unlikeampicillin, cephalothin is resistant to penicillinase producedby S. aureus and provides an alternative to the use ofpenicillinase-resistant penicillins for the treatment of infectionscaused by such strains.
Cephalothin is absorbed poorly from the GI tract andmust be administered parenterally for systemic infections. It is relatively nontoxic and acid stable. It is excreted rapidlythrough the kidneys; about 60% is lost within 6 hours of administration.Pain at the site of intramuscular injection andthrombophlebitis following intravenous injection have beenreported. Hypersensitivity reactions have been observed,and there is some evidence of cross-sensitivity in patientsnoted previously to be penicillin sensitive.

Cephalothin sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Cephalothin sodium Suppliers

Global( 230)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
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Hubei xin bonus chemical co. LTD
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Chongqing Chemdad Co., Ltd
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Alchem Pharmtech,Inc.
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CONIER CHEM AND PHARMA LIMITED
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career henan chemical co
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0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 4105 58

View Lastest Price from Cephalothin sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Cephalothin
58-71-9
US $50.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-07-01 Cephalothin USP/EP/BP
58-71-9
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-08-26 Cephalothin
58-71-9
US $225.00 / KG 1KG 99%min 8000 Kilogram/Kilograms per Month Hebei Runbin Biotechnology Co. LTD

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