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Cephalothin

Cephalothin
Cephalothin structure
CAS No.
58-71-9
Chemical Name:
Cephalothin
Synonyms
38253;Coaxin;Keflin;Seffin;Microtin;Averon 1;Cemastin;Lospoven;Cephation;Ceporacin
CBNumber:
CB9443527
Molecular Formula:
C16H15N2NaO6S2
Formula Weight:
418.42
MOL File:
58-71-9.mol

Cephalothin Properties

Melting point:
240°C
alpha 
D +135° (c = 1.0 in water)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, faintly yellow
form 
neat
Water Solubility 
158 mg/L
Merck 
13,1994
BRN 
4120706
CAS DataBase Reference
58-71-9(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  42/43
Safety Statements  22-36/37
WGK Germany  2
RTECS  XI0388300
HS Code  29419000
Toxicity LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Cephalothin price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4520 Cephalothin sodium salt 96.0-101.0% 58-71-9 1g $104 2018-11-20 Buy
Sigma-Aldrich 1102000 Cephalothin sodium United States Pharmacopeia (USP) Reference Standard 58-71-9 200mg $352.8 2018-11-20 Buy
Alfa Aesar J65607 Cephalothin sodium salt 58-71-9 5g $308 2018-11-13 Buy
Alfa Aesar J65607 Cephalothin sodium salt 58-71-9 1g $86.3 2018-11-13 Buy
Cayman Chemical 26063 Cefalothin (sodium salt) ≥98% 58-71-9 250mg $35 2018-11-19 Buy

Cephalothin Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Uses

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics,strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics,and for immunology studies in relation to antibiotics.It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

brand name

Keflin (Lilly); Seffin (GlaxoSmithKline).

Clinical Use

Cephalothin sodium (Keflin) occurs as a white to off-white,crystalline powder that is practically odorless. It is freelysoluble in water and insoluble in most organic solvents.Although it has been described as a broad-spectrum antibacterialcompound, it is not in the same class as the tetracyclines.Its spectrum of activity is broader than that ofpenicillin G and more similar to that of ampicillin. Unlikeampicillin, cephalothin is resistant to penicillinase producedby S. aureus and provides an alternative to the use ofpenicillinase-resistant penicillins for the treatment of infectionscaused by such strains.
Cephalothin is absorbed poorly from the GI tract andmust be administered parenterally for systemic infections. It is relatively nontoxic and acid stable. It is excreted rapidlythrough the kidneys; about 60% is lost within 6 hours of administration.Pain at the site of intramuscular injection andthrombophlebitis following intravenous injection have beenreported. Hypersensitivity reactions have been observed,and there is some evidence of cross-sensitivity in patientsnoted previously to be penicillin sensitive.

Cephalothin Preparation Products And Raw materials

Raw materials

Preparation Products


Cephalothin Suppliers

Global( 157)Suppliers
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Henan DaKen Chemical CO.,LTD.
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