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Acetanilide structure
Chemical Name:
ACETANIL;NSC 7636;usafek-3;Phenalgin;USAF ek-3;NSC 203231;ANTIFEBRIN;Phenalgene;Acetanilid;Acetanildie
Molecular Formula:
Formula Weight:
MOL File:

Acetanilide Properties

Melting point:
113-115 °C(lit.)
Boiling point:
304 °C(lit.)
1,121 g/cm3
vapor density 
4.65 (vs air)
vapor pressure 
1 mm Hg ( 114 °C)
refractive index 
1.5700 (estimate)
Flash point:
173 °C
storage temp. 
Store below +30°C.
0.5(at 25℃)
Off-white to beige to grayish-blue
5-7 (10g/l, H2O, 25℃)
Water Solubility 
5 g/L (25 ºC)
Stable. Combustible. Incompatible with strong oxidizing agents, caustics, alkalies.
CAS DataBase Reference
103-84-4(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N-phenyl-(103-84-4)
EPA Substance Registry System
Acetamide, N-phenyl-(103-84-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-26-36
WGK Germany  1
RTECS  AD7350000
Autoignition Temperature 540 °C
HS Code  29242995
Hazardous Substances Data 103-84-4(Hazardous Substances Data)
Toxicity LD50 intragastric in rats: 800 mg/kg (Smith, Hambourger)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
Health   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)

(NFPA, 2010)

Acetanilide price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00401 Acetanilide puriss. p.a., ≥99.5% (CHN) 103-84-4 5g $83.7 2018-11-13 Buy
Sigma-Aldrich 1003042 Acetaminophen Related Compound D United States Pharmacopeia (USP) Reference Standard 103-84-4 50mg $1110 2018-11-13 Buy
Alfa Aesar A14361 Acetanilide, 98% 103-84-4 100g $24.1 2018-11-13 Buy
Alfa Aesar A14361 Acetanilide, 98% 103-84-4 500g $48.2 2018-11-13 Buy
Sigma-Aldrich 112933 Acetanilide 99% 103-84-4 500g $58.9 2018-11-13 Buy

Acetanilide Chemical Properties,Uses,Production

Chemical Properties

grey or white powder or flakes

Chemical Properties

Acetanilide orthorhombic plates or scales; or white, shining, crystalline solid or powder. Odorless




The first aniline derivative found to possess analgesic and antipyretic properties.


manufacture of medicinals and dyes; stabilizer for H2O2 solution; as addition to cellulose ester varnishes.


ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group.


acetanilide: A white crystalline primaryamide of ethanoic acid,CH3CONHC6H5; r.d. 1.2; m.p. 114.3°C;b.p. 304°C. It is made by reactingphenylamine (aniline) with excessethanoic acid or ethanoic anhydrideand is used in the manufacture ofdyestuffs and rubber. The full systematicname is N-phenylethanamide.

World Health Organization (WHO)

Acetanilide, a para-aminophenol derivative with analgesic, antipyretic and weak antiinflammatory activity, was introduced into medicine in 1886. It subsequently proved to be excessively myelosuppressive and has been superseded by safer alternatives.

General Description

White to gray solid.

Air & Water Reactions

Acetanilide is sensitive to prolonged exposure to air . Water insoluble.

Reactivity Profile

Acetanilide is an amide. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Acetanilide is combustible.

Safety Profile

A human poison by an unspecified route. Poison by ingestion and intravenous routes. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hallucinations and dstorted perceptions, sleepiness, constipation, cyanosis, respiratory stimulation, hdney damage, me themoglobinemiacarboxyhemoglobinemia, and decreased body temperature. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. Combustible when exposed to heat or flame. See also ANILINE.

Potential Exposure

This amide compound is used in rubber industry as accelerator, in plastics industry as cellulose ester stabilizer, in pharmaceutical manufacture, stabilizer for hydrogen peroxide, azo dye manufacture

Enzyme inhibitor

This acetylated aniline (FW = 135.17 g/mol; CAS 103-84-4 M.P. = 113- 115°C) is a component in the synthesis of numerous pharmaceuticals, inhibitors, and dyes. Acetanilide is toxic in vivo, owing in part to its hydrolysis to aniline, with consequential methemoglobinemia. Target (s) : chymotrypsin; D-3-hydroxybutyrate dehydrogenase; and amidase, also as an alternative substrate.

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a oneway valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In the case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Recrystallise acetanilide from water, aqueous EtOH, *benzene or toluene. [Beilstein 12 IV 373.]


Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alkyl nitrates, alkalis (liberate aniline), chloral hydrate, phenols, ferric salts

Waste Disposal

Add to flammable solvents (alcohol or benzene) and incinerate. Oxides of nitrogenmay be scrubbed from combustion gases with alkaline solution

Acetanilide Preparation Products And Raw materials

Raw materials

Preparation Products

Acetanilide Suppliers

Global( 226)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Springchem New Material Technology Co.,Limited
86-21-51752789 China 896 57
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1750 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
career henan chemical co
+86-371-86658258 CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23983 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20094 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4660 58

View Lastest Price from Acetanilide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-14 Acetanilide
US $1.00 / kg 1kg 99% 100KGS career henan chemical co

Acetanilide Spectrum

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