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2-Acetoxy-4-trifluoromethylbenzoic acid

2-Acetoxy-4-trifluoromethylbenzoic acid
2-Acetoxy-4-trifluoromethylbenzoic acid structure
CAS No.
322-79-2
Chemical Name:
2-Acetoxy-4-trifluoromethylbenzoic acid
Synonyms
ur1501;Drisgen;Disgren;TRIFLUSAL;Triflusal-d3;Triflusal CRS;TRIFLUOROTRIMESICACID;4-trifluoromethylsalicylicacidacetate;acetyl-4-trifluoromethylsalicylic acid;2-acetoxy-4-trifluoromethylbenzoic acid
CBNumber:
CB9446472
Molecular Formula:
C10H7F3O4
Formula Weight:
248.16
MOL File:
322-79-2.mol

2-Acetoxy-4-trifluoromethylbenzoic acid Properties

Melting point:
120-122° (upon slow heating); 110-112° (upon quick heating)
Boiling point:
316.0±42.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: >30mg/mL
pka
2.97±0.10(Predicted)
form 
powder
color 
white to off-white
λmax
297nm(H2O)(lit.)
Merck 
14,9688
CAS DataBase Reference
322-79-2(CAS DataBase Reference)
FDA UNII
1Z0YFI05OO
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319-H335
Precautionary statements  P280-P301+P312+P330-P305+P351+P338-P261
Hazard Codes  Xn
Risk Statements  22-36/37/38-43
Safety Statements  26-36/37
WGK Germany  3
RTECS  GP4250000

2-Acetoxy-4-trifluoromethylbenzoic acid price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T6580 Triflusal ≥98% (HPLC) 322-79-2 5mg $108 2021-03-22 Buy
Sigma-Aldrich T2005000 Triflusal European Pharmacopoeia (EP) Reference Standard 322-79-2 $190 2021-03-22 Buy
Sigma-Aldrich T6580 Triflusal ≥98% (HPLC) 322-79-2 25mg $419 2021-03-22 Buy
TCI Chemical T3601 Triflusal >98.0%(T) 322-79-2 250mg $186 2021-03-22 Buy
TCI Chemical T3601 Triflusal >98.0%(T) 322-79-2 1g $555 2021-03-22 Buy

2-Acetoxy-4-trifluoromethylbenzoic acid Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

An analog of Aspirin; inhibits platelet aggregation. Antithrombotic.

Uses

Antithrombotic;Cyclooxygenase inhibitor

Mechanism of action

2-hydroxy-4-trifluoromethylbenzoic acid (HTB), the deacetylated metabolite of triflusal, retains significant antiplatelet activity. Triflusal is rapidly absorbed and metabolized. The area under the concentration–time curve for triflusal is 20.26 mg/L/hour after a 900-mg dose, whereas that for HTB is 42.27 mg/L/hour. Much of the pharmacokinetic data for triflusal activity is associated with HTB. The inhibition of COX, as measured by reduced production of thromboxane B2, is 25% after 2 hours and 85% after 7 days with triflusal, whereas the effects of aspirin on thromboxane B2 is more than 90% reduction after 2 hours and is maintained at this level after 7 days. It would appear that the presence of a 4-trifluoromethyl group also greatly enhances triflusal's ability to inhibit the activation of nuclear factor κB, which in turn regulates the expression of the mRNA of vascular cell adhesion molecule-1 needed for platelet aggregation. In addition, triflusal increases nitric oxide synthesis in neutrophils, which results in an increased vasodilatory potential. Finally, an additional site of action for triflusal/HTB is the inhibition of cAMP phosphodiesterase, leading to increased levels of cAMP. Elevated cAMP levels decrease platelet aggregation through decreased mobilization of calcium. Aspirin and salicylic acid do not significantly increase cAMP levels.

Clinical Use

Triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) is an antiplatelet drug that despite its structural similarity to aspirin exhibits quite different pharmacological and pharmacokinetic properties.

2-Acetoxy-4-trifluoromethylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products


2-Acetoxy-4-trifluoromethylbenzoic acid Suppliers

Global( 158)Suppliers
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Capot Chemical Co.,Ltd.
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Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
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career henan chemical co
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Hubei Jusheng Technology Co.,Ltd.
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Shandong chuangyingchemical Co., Ltd.
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BOC Sciences
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Alchem Pharmtech,Inc.
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CONIER CHEM AND PHARMA LIMITED
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View Lastest Price from 2-Acetoxy-4-trifluoromethylbenzoic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 2-Acetoxy-4-trifluoromethylbenzoic acid
322-79-2
US $0.00-0.00 / KG 1mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
2019-07-06 2-Acetoxy-4-trifluoromethylbenzoic acid
322-79-2
US $1.00 / KG 1KG 98% 150kg career henan chemical co

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