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1-Boc-4-(2-hydroxyethyl)piperidine

1-Boc-4-(2-hydroxyethyl)piperidine structure

CAS No.: 89151-44-0

Chemical Name:: 1-Boc-4-(2-hydroxyethyl)piperidine

Synonyms: tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate;Tirofiban Impurity 57;N-BOC-4-PIPERIDINEETHANOL;1-Boc-4-piperidineethanol;1-BOC-4-PIPERIDINE EHTANOL;BOC-2-(4-PIPERIDYL)ETHANOL;1-Boc-4-(hydroxyethyl)pip...;N-BOC-4-piperidine-β-ethanol;N-Boc-4-piperidineethanol 97%;N-Boc-4-piperidineethanol 97%

CBNumber:: CB9449817

Molecular Formula:: C12H23NO3

Molecular Weight:: 229.32

MDL Number:: MFCD03427086

MOL File:: 89151-44-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
N-Boc-4-piperidineethanol 97%	547247	5g	$58.58
N-Boc-4-piperidineethanol 97%	547247	1g	$30
N-BOC-4-piperidine-β-ethanol	B657230	10g	$200
4-(2-Hydroxyethyl)piperidine, N-Boc protected	4H01-1-X3	25g	$136
tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate >95%	069039	25g	$145
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1-Boc-4-(2-hydroxyethyl)piperidine Properties

Boiling point	120-150 °C/0.5 mmHg (lit.)
Density	1.043 g/mL at 25 °C (lit.)
refractive index	n20/D 1.4730(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	15.10±0.10(Predicted)
form	viscous liquid
color	Colourless to light yellow
InChI	InChI=1S/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-10(5-8-13)6-9-14/h10,14H,4-9H2,1-3H3
InChIKey	YBNJZIDYXCGAPX-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(CCO)CC1
CAS DataBase Reference	89151-44-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xi
WGK Germany	3
HS Code	2933399990

1-Boc-4-(2-hydroxyethyl)piperidine price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	547247	N-Boc-4-piperidineethanol 97%	89151-44-0	5g	$58.58	2025-07-31	Buy
Sigma-Aldrich	547247	N-Boc-4-piperidineethanol 97%	89151-44-0	1g	$30	2023-06-20	Buy
TRC	B657230	N-BOC-4-piperidine-β-ethanol	89151-44-0	10g	$200	2021-12-16	Buy
SynQuest Laboratories	4H01-1-X3	4-(2-Hydroxyethyl)piperidine, N-Boc protected	89151-44-0	25g	$136	2021-12-16	Buy
Matrix Scientific	069039	tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate >95%	89151-44-0	25g	$145	2021-12-16	Buy

Product number	Packaging	Price	Buy
547247	5g	$58.58	Buy
547247	1g	$30	Buy
B657230	10g	$200	Buy
4H01-1-X3	25g	$136	Buy
069039	25g	$145	Buy

1-Boc-4-(2-hydroxyethyl)piperidine Chemical Properties,Uses,Production

Uses

N-BOC-4-piperidine-β-ethanol is used to prepare anilinoquinazoline VEGF receptor tyrosine kinase inhibitors with antitumor activities. It is also used to synthesize 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists with antiviral activities.

Synthesis

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

135716-08-4

89151-44-0

General procedure for the synthesis of N-Boc-4-piperidine ethanol from tert-butyl 4-(2-ethoxy-2-oxo-substituted)piperidine-1-carboxylate: first, the above product (639 mg, 2.4 mmol) was dissolved in 6 mL of methanol, protected by argon, replaced three times with hydrogen and reacted overnight in a hydrogenation unit (4 atm H2). Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and washed with ethyl acetate. The filtrate was concentrated and purified by column chromatography to give a white solid product (722 mg, 100% yield). Subsequently, the above product (506 mg, 1.9 mmol) was dissolved in 10 mL of ether, cooled to -20 °C, and hydrogenated diisobutylaluminum (1.0 M, 5 mL, 5 mmol) was slowly added, and the reaction was carried out for 10 min until the raw material completely disappeared. The reaction mixture was poured into saturated potassium sodium tartrate solution and stirred at room temperature for 3 hours until clarified. The aqueous phase was extracted three times with ether, the organic phases were combined, washed with saturated NaCl solution and dried over anhydrous Na2SO4. After concentration, the product was purified by column chromatography to give a white solid product (368 mg, 86% yield).

References

[1] Patent: CN102952072, 2016, B. Location in patent: Paragraph 0110-0111
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 13, p. 2167 - 2172
[3] Patent: US2012/71461, 2012, A1
[4] Patent: CN107793408, 2018, A
[5] Patent: WO2018/68297, 2018, A1

1-Boc-4-(2-hydroxyethyl)piperidine Preparation Products And Raw materials

Raw materials

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 4-Piperidineethanol tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate Carbonic acid, bis(1,1-dimethylethyl) ester Di-tert-butyl dicarbonate

Diethyl ether Activated carbon Methanol Hydrogen Diisobutylaluminium hydride

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Preparation Products

tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate 1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE Piperidine, 4-(2-methoxyethyl)-, hydrochloride (1:1) tert-butyl 4-(2-Methoxyethyl)piperidine-1-carboxylate

1-Boc-4-(2-hydroxyethyl)piperidine Suppliers

Global( 253)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Chembon Pharmaceutical Co., Ltd.	55
Zjartschem	58
career henan chemical co	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 1-Boc-4-(2-hydroxyethyl)piperidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0	US $1.00 / KG	1KG	99%	1ton	Career Henan Chemical Co
	2019-07-06	1-Boc-4-(2-hydroxyethyl)piperidine 89151-44-0	US $1.00 / KG	1KG	99%	1000KG	Career Henan Chemical Co

1-Boc-4-(2-hydroxyethyl)piperidine
89151-44-0
US $1.00 / KG
99%
Career Henan Chemical Co

1-Boc-4-(2-hydroxyethyl)piperidine
89151-44-0
US $1.00 / KG
99%
Career Henan Chemical Co

1-Boc-4-(2-hydroxyethyl)piperidine Spectrum

1-Boc-4-(2-hydroxyethyl)piperidine(89151-44-0)¹HNMR

89151-44-0(1-Boc-4-(2-hydroxyethyl)piperidine)Related Search:

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Butylparaben 4-Piperidineethanol Butyl acrylate

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N-BOC-4-PIPERIDINEETHANOL N-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEETHANOL 1-BOC-4-(2-HYDROXYETHYL)PIPERIDINE 4-(2-HYDROXYETHYL)PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-2-(4-PIPERIDYL)ETHANOL 4-(2-Hydroxyethyl)piperidine, N-BOC protected 1-BOC-4-PIPERIDINE EHTANOL 1-PIPERIDINECARBOXYLIC ACID, 4-(2-HYDROXYETHYL)-1, N-TERT-BUTOXYCARBONYL-4-PIPERIDINEETHANOL 95+% Boc 4-(2-Hydroxyethyl)piperidine 1-Boc-4-(hydroxyethyl)piperidine N-Boc-4-piperidineethanol,N-(tert-Butoxycarbonyl)-4-piperidineethanol 1-Boc-4-(hydroxyethyl)pip... tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine 1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-, 1,1-diMethylethyl ester N-Boc-4-piperidineethanol 97% 1-Boc-4-piperidineethanol Tirofiban Impurity 57 N-BOC-4-piperidine-β-ethanol N-Boc-4-(2-hydroxyethyl)piperidine tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate N-Boc-4-piperidineethanol N-Boc-4-piperidineethanol 97% 89151-44-0 Building Blocks Piperidines Heterocyclic Building Blocks Building Blocks C12 Chemical Synthesis Heterocyclic Building Blocks Piperidines pharmacetical