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Tibolone

CAS No.
5630-53-5
Chemical Name:
Tibolone
Synonyms
LIVIAL;Tiblone;LIVIELLA;TIBOLONE;Tiboione;tibolona;Org OD 14;tibolonum;Tibolone(EP);Tibolone IMpurity
CBNumber:
CB9453050
Molecular Formula:
C21H28O2
Molecular Weight:
312.45
MDL Number:
MFCD00864178
MOL File:
5630-53-5.mol
MSDS File:
SDS
Last updated:2024-01-18 17:18:22

Tibolone Properties

Melting point 169 °C
Boiling point 447.4±45.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
refractive index 105 ° (C=0.54, CH2Cl2/Et2O)
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
pka 13.10±0.60(Predicted)
color white to beige
Merck 9427
InChI InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/s3
InChIKey WZDGZWOAQTVYBX-PGFZCDQENA-N
SMILES [C@@]12([H])[C@H](C)CC3CC(=O)CCC=3[C@@]1([H])CC[C@]1(C)[C@](CC[C@@]21[H])(O)C#C |&1:0,2,12,16,18,21,r|
CAS DataBase Reference 5630-53-5(CAS DataBase Reference)
FDA UNII FF9X0205V2
NCI Drug Dictionary tibolone
ATC code G03CX01

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  N
Risk Statements  51/53
Safety Statements  22-24/25-61
RIDADR  UN 3077 9/PG 3
RTECS  RC8964020
NFPA 704
0
2 0

Tibolone price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000668 Tibolone for system suitability European Pharmacopoeia (EP) Reference Standard 5630-53-5 y0000668 $153 2024-03-01 Buy
Cayman Chemical 10006321 Tibolone ≥98% 5630-53-5 100mg $34 2024-03-01 Buy
Cayman Chemical 10006321 Tibolone ≥98% 5630-53-5 250 mg $81 2024-03-01 Buy
Cayman Chemical 10006321 Tibolone ≥98% 5630-53-5 500mg $152 2024-03-01 Buy
Cayman Chemical 10006321 Tibolone ≥98% 5630-53-5 1 g $287 2024-03-01 Buy
Product number Packaging Price Buy
Y0000668 y0000668 $153 Buy
10006321 100mg $34 Buy
10006321 250 mg $81 Buy
10006321 500mg $152 Buy
10006321 1 g $287 Buy

Tibolone Chemical Properties,Uses,Production

Description

Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.

Chemical Properties

White Solid

Originator

Akzo (Organon) (The Netherklands)

Uses

A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome

Definition

ChEBI: Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormon receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.

brand name

Livial

Pharmacokinetics

Raloxifene is rapidly absorbed following oral administration, with an estimated 60% absorption, but it has a very low bioavailability (2%), associated with extensive phase II metabolism. The metabolites are excreted via the bile, with potential enterohepatic recycling that could account for the interaction with cholestyramine. Supportive of the enterohepatic recycling is the half-life of 28 hours. Metabolism of raloxifene occurs to a great extent in the intestine and consists of glucuronide conjugation catalyzed by uridine diphosphate glucuronosyltransferase (UGT).

Clinical Use

Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable alternative to conjugated equine estrogen plus micronized progesterone.

Side effects

The most common reason for patient withdrawal from clinical trials was vaginal bleeding (also a common side effect when estrogen therapy is used).

15506-05-5
5630-53-5
Synthesis of Tibolone from 2-Dehydro-3-Methoxy Tibolone

Tibolone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 179)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Aoliqisi New Material Technology Co., Ltd.
+86-13545906766; +8613545906766 sales@whaop.com China 265 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 616 58
Wuhan Xinhao Biotechnology Co., Ltd
+86-18120578002 +86-18120578002 xinhao-6@xinhaoshengwu.com China 350 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co
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Xiamen AmoyChem Co., Ltd
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86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

View Lastest Price from Tibolone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tibolone pictures 2024-03-26 Tibolone
5630-53-5
US $10.00-100.00 / kg 1kg 99% 100 tons Wuhan Xinhao Biotechnology Co., Ltd
Tibolone pictures 2024-03-08 Tibolone
5630-53-5
US $10.00 / kg 1kg 99% 1000kg Nantong Guangyuan Chemicl Co,Ltd
Tibolone pictures 2024-03-08 Tibolone
5630-53-5
US $10.00 / kg 1kg 99% 1000kg Nantong Guangyuan Chemicl Co,Ltd
  • Tibolone pictures
  • Tibolone
    5630-53-5
  • US $10.00-100.00 / kg
  • 99%
  • Wuhan Xinhao Biotechnology Co., Ltd
  • Tibolone pictures
  • Tibolone
    5630-53-5
  • US $10.00 / kg
  • 99%
  • Nantong Guangyuan Chemicl Co,Ltd
  • Tibolone pictures
  • Tibolone
    5630-53-5
  • US $10.00 / kg
  • 99%
  • Nantong Guangyuan Chemicl Co,Ltd
TIBOLONE LIVIELLA LIVIAL 5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE (7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE 17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one 17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREGN-5(10)-EN-20-YN-3-ONE 19-NORPREGN-5(10)-EN-20-YN-3-ONE,17-HYDROXY-7-METHYL-, (7A,17A)- 17β-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-ene-20-yn-3-one (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one 7a-Methyl-17a-ethynyl-17-hydroxy-5(10)-estren-3-one 7a-Methyl-5,10-norethindrone Org OD 14 (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7alpha,17alpha)- 7a-Methyl-17a-ethynyl-17b-hydroxy-5(10)-estren-3-one 7a-Methyl-D5,10-norethindrone Tibolone 17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one 17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one 5(10)-Estren-7α-methyl-17α- ethynyl-17β- ol-3-one Tiboione Tibolone(EP) 7α-Methyl-17α-ethynyl-17β-hydroxy-5(10)-estren-3-one 7α-Methyl-5,10-norethindrone (7R,13S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one (7R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one Tiblone Tibolone for system suitability CRS tibolona tibolonum 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)- (7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one Tibolone USP/EP/BP Tibolone D5Q: What is Tibolone D5 Q: What is the CAS Number of Tibolone D5 Q: What is the storage condition of Tibolone D5 Q: What are the applications of Tibolone D5 TiboloneQ: What is Tibolone Q: What is the CAS Number of Tibolone Q: What is the storage condition of Tibolone Q: What are the applications of Tibolone 5(10)-ESTREN-7α-METHYL-17α- ETHYNYL-17β- OL-3-ONE Tibolone IMpurity 5630-53-5 5630-53-6 Steroid and Hormone Active Pharmaceutical Ingredients Hormone Acetylenes Biochemistry Functionalized Acetylenes Hydroxyketosteroids Steroids Intermediates & Fine Chemicals Pharmaceuticals