Plerixafor 8HCl (AMD3100 8HCl)

Plerixafor 8HCl (AMD3100 8HCl) Properties

Melting point	188 - 193°C (dec.)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	H₂O: ≥10 mg/mL, clear
form	solid
color	White
Water Solubility	Soluble in water (100mM)
Stability	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
EWG's Food Scores	1
NCI Dictionary of Cancer Terms	AMD 3100
FDA UNII	OD49913540

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS02
Signal word	Danger
Hazard statements	H314-H226
Precautionary statements	P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405
Safety Statements	22-24/25
WGK Germany	3

Plerixafor 8HCl (AMD3100 8HCl) price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	239825	InSolution? CXCR4 Antagonist I, AMD3100	155148-31-5	15mg	$225	2024-03-01	Buy
Sigma-Aldrich	239820	CXCR4 Antagonist I, AMD3100	155148-31-5	5mg	$142	2024-03-01	Buy
Cayman Chemical	10011332	Plerixafor (hydrochloride hydrate) ≥98%	155148-31-5	1mg	$18	2024-03-01	Buy
Cayman Chemical	10011332	Plerixafor (hydrochloride hydrate) ≥98%	155148-31-5	5mg	$73	2024-03-01	Buy
Sigma-Aldrich	A5602	AMD3100 octahydrochloride hydrate ≥97% (NMR), solid	155148-31-5	5mg	$123	2024-03-01	Buy

Product number	Packaging	Price	Buy
239825	15mg	$225	Buy
239820	5mg	$142	Buy
10011332	1mg	$18	Buy
10011332	5mg	$73	Buy
A5602	5mg	$123	Buy

Plerixafor 8HCl (AMD3100 8HCl) Chemical Properties,Uses,Production

Description

Plerixafor (155148-31-5) is a highly selective CXCR4 antagonist (IC50 = 20-130 nM).1,2 Originally investigated as an HIV replication inhibitor.3 Plerixafor has been investigated for the treatment autoimmune diseases and various cancers.4 Clinically useful for the mobilization of hematopoietic stem cells in the treatment of blood cancers.

Uses

Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).

Uses

A specific CXCR4 antagonist.

Uses

Plerixafor 8HCl (AMD3100 8HCl) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively - See more at: http://www.selleckchem.com/products/plerixafor-8hcl-db06

General Description

A symmetrical bicyclam compound that antagonizes CXCL12 (SDF1) binding to CXCR4 (IC₅₀ = 108 and 245 nM using rat and human CXCR4, respectively) and inhibits SDF1-induced Ca²⁺ flux (by 100% at 100 ng/ml in SUP-T1 and THP-1 cultures) as well as CXCR4-, but not CCR5-, mediated HIV infection (IC₅₀ ≤200 nM), while enhancing the binding of SDF1 to CXCR7 (by ~60% at 1 mM with CXCR7-expressing HEK293T cells) and SDF1-induced β-arrestin recruitment to CXCR7 (EC₅₀ = 6.48 and 11.8 nM, in the presence and absence of 10 μM AMD3100, respectively). Administration AMD3100 via intravenous infusion is also reported to result in hematopoietic stem cell mobilization in humans, dogs, and mice in vivo. Exhibits no inhibitory effects against chemokine-induced signaling via CXCR1/2/3 or CCR1/2/3/4/5/6/7/8/9.

Biological Activity

Highly selective CXCR4 chemokine receptor antagonist (IC 50 values are 0.02 - 0.13 and > 25 μ M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC 50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo .

Biochem/physiol Actions

Cell permeable: yes

Clinical Use

Plerixafor hydrochloride, a chemokine CXCR4 (SDF-1) antagonist, was launched by Genzyme for the treatment of enhancing mobilization of hematopoietic stem cells for autologous transplantation in patients with lymphoma and enhancing mobilization of hematopoietic stem cells for transplantation in patients with multiple myeloma. Being a CXCR4 antagonist, a specific cellular chemokine receptor, plerixafor triggers the rapid movement of stem cells out of the bone marrow and into circulating blood where the stem cells can be collected for use in stem cell transplants. Regarding its use for cardiac applications, some clinical data suggests that the presence of stem cells circulating in the bloodstream or directly injected into the hearts of patients who have suffered a heart attack may result in improved cardiac function.

Synthesis

A concise one-pot synthesis was achieved by a rather novel nitrogen protecting strategy. Tetraazacyclotetradecane 88 was protected as its phosphorotriamide 89 by reaction with POCl3 and Et3N in hot DMF. Without isolation, compound 89 was bis-alkylated with dibromide 90 in the presence of sodium carbonate in refluxing DMF overnight to give bis-phosphoramide 91. The crude dimeric bis-phosphoramide was hydrolyzed with 3 M HCl to afford plerixafor hydrochloride (XV) in 62¨C68% yield.

Synthesis_155148-31-5

storage

-20°C (desiccate)

References

1) Donzella, et al. (1998), AMD3100, A Small Molecule Inhibitor of HIV-1 Entry via the CXCR4 Co-Receptor; Nat. Med. 4 72 2) Hatse et al. (2002), Chemokine Receptor Inhibition by AMD3100 Is Strictly Confined to CXCR4; FEBS Lett. 527 255 3) Bridger et al. (1995), Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the aromatic Linker; J. Med. Chem. 38 366 4) Wang et al. (2020), CXCR4 antagonist AMD3100 (plerixafor): from an impurity to a therapeutic agent; Pharmacol. Res. 159 105010

Plerixafor 8HCl (AMD3100 8HCl) Preparation Products And Raw materials

Raw materials

Preparation Products

Plerixafor 8HCl (AMD3100 8HCl) Suppliers

Global( 188)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7377	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12431	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	+8615065888978	admin@hsnordpharma.com	China	92	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hebei Guanlang Biotechnology Co., Ltd.	58
career henan chemical co	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from Plerixafor 8HCl (AMD3100 8HCl) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-16	Plerixafor 8HCl (AMD3100 8HCl) 155148-31-5	US $3.00-1.00 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-08-02	Plerixafor 8HCl (AMD3100 8HCl) 155148-31-5	US $50.00 / kg	1kg	99.9%	10000MT	Henan Bao Enluo International TradeCo.，LTD
2023-07-01	Plerixafor 8HCl (AMD3100 8HCl) 155148-31-5	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Plerixafor 8HCl (AMD3100 8HCl)
155148-31-5
US $3.00-1.00 / kg
99%
Henan Fengda Chemical Co., Ltd

Plerixafor 8HCl (AMD3100 8HCl)
155148-31-5
US $50.00 / kg
99.9%
Henan Bao Enluo International TradeCo.，LTD

Plerixafor 8HCl (AMD3100 8HCl)
155148-31-5
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Plerixafor 8HCl (AMD3100 8HCl) Spectrum

Plerixafor 8HCl (AMD3100 8HCl)(155148-31-5)MS Plerixafor 8HCl (AMD3100 8HCl)(155148-31-5)¹HNMR

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Plerixafor PROTRIPTYLINE HYDROCHLORIDE Pramipexole Impurity 4 PLERIXAFOR Tetradecane

METHYL-2-PYRROLIDONE 1-Benzyl-1,4,8,11-tetraazacyclotetradecane 1,4,8,11-TETRAAZACYCLOTETRADECANE

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SID791 AMD3100 BISCYCLAM JM3100 AMD3100 OCTAHYDROCHLORIDE HYDRATE ANHYDROUS amd3100 octahydrochloride hydrate 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride, min. 95 % (NMR) AMD3100 hydrate octahydrochloride JM3100, SID791, 1,1μ-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] 1,1'-[1,4-PHENYLENEBIS(METHYLENE)]BIS-1,4,8,11-TETRAAZACYCLOTETRADECANE OCTAHYDROCHLORIDE 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-, octahydrochloride Bicyclam Plerixafor hydrochloride Plerixafor hcl Plerixafor (hydrochloride hydrate) Plerixafor HCL(JM 3100) Plerixafor 8HCl (DB06809) Plerixafor (octahydrochloride) Plerixafor 8HCl (AMD3100 8HCl) Plerixafor(SynonyM: AMD3100 octahydrochloride hydrate) 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8) JM 3100 8HCl AMD 3100 octahydrochloride(8HCl) AMD 3100 octahydrochloride, >=98% Plerixafor 8HCl 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride hydrate AMD3100 HCl JM3100 octahydrochloride SID791 octahydrochloride InSolution? CXCR4 Antagonist I, AMD3100 CXCR4 Antagonist I, AMD3100 AMD3100 OCTAHYDROCHLORIDE AMD3100 OCTAHYDROCHLORIDE;AMD-3100; AMD 3100 CS-907 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] hydrochloride (1:8) InSolution CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 - Calbiochem Plerixafor-d8 8HCl AMD3100 8HCl Plerixafor Hydrochloride (1:8) 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene Octahydrochloride Plerixafor 8HCl (AMD3100 8HCl) USP/EP/BP Plerixafor hydrochloride salt AMD 3100 octahydroch Plerixafor 8HCl (AMD3100) 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclo... 1-[[4-(1,4,8,11-Tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecaneoctahydrochloride Plerixafor 13C6 Hydrochloride Plerixafore 8HCl Plerixafor (AMD3100) 8HCl SID791 8HCl 155148-31-5 C28H54N8 C28H54N88HClxH2O C28H54N88HCl C28H62Cl8N8 Cell Signaling and Neuroscience