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Pergolide mesylate salt

Pergolide mesylate salt
Pergolide mesylate salt structure
CAS No.
66104-23-2
Chemical Name:
Pergolide mesylate salt
Synonyms
MPE;Nopar;Permax;Celance;Veceral;Pergolin;ly127809;NSC 319773;PERGOLIDE MESYLATE;Pergolide mesilate CRS
CBNumber:
CB9455089
Molecular Formula:
C20H30N2O3S2
Formula Weight:
410.59
MOL File:
66104-23-2.mol

Pergolide mesylate salt Properties

Melting point:
252-254°C
alpha 
aD20 between -18.0° and -23.0° (c = 10 mg/ml in DMF)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
ethanol: soluble2mg/mL
form 
solid
pka
pKa (66% DMF) 7.8(at 25℃)
color 
white
optical activity
[α]20/D 35°, c = 0.2 in pyridine(lit.)
CAS DataBase Reference
66104-23-2(CAS DataBase Reference)
FDA UNII
55B9HQY616
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P301+P310
Hazard Codes  T+
Risk Statements  28
Safety Statements  28-36/37-45
RIDADR  UN 1544
WGK Germany  3
RTECS  KE6345000
HS Code  2939690000

Pergolide mesylate salt price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P8828 Pergolide mesylate salt ≥98%, solid 66104-23-2 25mg $56.6 2018-11-13 Buy
Sigma-Aldrich 1510845 Pergolide mesylate United States Pharmacopeia (USP) Reference Standard 66104-23-2 200mg $434 2021-03-22 Buy
Cayman Chemical 26085 Pergolide (mesylate) ≥95% 66104-23-2 25mg $45 2021-03-22 Buy
Cayman Chemical 26085 Pergolide (mesylate) ≥95% 66104-23-2 50mg $86 2021-03-22 Buy
Sigma-Aldrich P8828 Pergolide mesylate salt ≥98%, solid 66104-23-2 100mg $169 2018-11-13 Buy

Pergolide mesylate salt Chemical Properties,Uses,Production

Description

Pergolide mesylate is a potent, long-acting dopamine agonist useful in the treatment of Parkinson’s disease and hyperprolactinemia, Compared with lergotrile, pergolide mesylate has shown less toxicity and lower propensity for inducing psychosis.

Chemical Properties

White to Off-White Solid

Originator

Lilly (USA)

Uses

A dopaminergic agonist that also decrease plasma prolactin concentrations. An antiparkinsonian agent

Uses

glucocorticoid, antiinflammatory

Uses

dopamine receptor agonist, anti-Parkinson's agent

Definition

ChEBI: A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it i used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.

Manufacturing Process

Dimethyl disulfide (73.6 ml, 0.79 mol) and tri-n-butylphosphine (79.6 ml, 0.32 mol) were added to a solution of 9,10-dihydrolysergol in (8.1 g, 0.032 mol) in the 150 ml of anhydrous DMF and were stirred at room temperature for 6 hours under a nitrogen atmosphere. Dimethyl disulfide of the reaction mixture was removed under vacuo. A solution of the residue in ethyl acetate was extracted with 3.7% HCl (aq.). The aqueous layer was basified with ammonium hydroxide to a pH of 10 and then extracted with ethyl acetate. Removal of ethyl acetate followed by a silica gel column purification eluting with 10% MeOH/CH2Cl2 gave5.5.g of D-6-methyl-8β(methylthiomethyl)ergoline (60%).
A solution of D-6-methyl-8β-(methylthiomethyl)ergoline (0.4 g, 0.0014 mol) and NaI (0.63 g, 0.0042 mol) in 10 ml of propionic anhydride was refluxed for 40 hours. The reaction mixture was guenched with a 10% Na2CO3 solution and extracted by ethyl acetate. The combined organic layers were washed with a saturated brine solution, dried with magnesium sulfate and concentrated to produce oil. The oil was purified by silica gel column, eluting with 10% MeOH/CH2Cl2 to give 0.33 g of D-1,6-dipropionyl-8β(methylthiomethyl)ergoline.
LiAlH4 (0.6 g, 0.0156 mol) was slowly added to a solution of D-1,6dipropionyl-8β-(methylthiomethyl)ergoline in the 20 ml anhydrous THF at 0°C under nitrogene atmosphere. The mixture was stirred at 0°C for 30 min and then at room temperature for 4 hours. The reaction was cooled to 0°C and 0.6 ml of water was slowly added. The mixture was stirred at 0°C for 10 min and 1.8 ml of 15% NaOH (aq.) and 2.5 ml of water were added respectively. The mixture was stirred for 30 min at room temperature and then filtered. Excess of the solvent was removed under reduced pressure to give 150 mg of 8β-((methylthio)methyl)-6-propyl-ergoline or pergolide (yield: 68%). Ergoline,8-((methylthio)methyl)-6-propyl-, monomethanesulfonate, (8β)- may be prepared by mixing of components in solution.

brand name

Permax (Valeant).

Therapeutic Function

Dopamine agonist

Pergolide mesylate salt Preparation Products And Raw materials

Raw materials

Preparation Products


Pergolide mesylate salt Suppliers

Global( 120)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 4149 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29986 58

View Lastest Price from Pergolide mesylate salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Pergolide mesylate salt
66104-23-2
US $0.00-0.00 / KG 5mg 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
2020-02-26 Pergolide mesylate salt
66104-23-2
US $0.00-0.00 / KG 100g 99%+ 10 tons Shaanxi Dideu Medichem Co. Ltd
2019-07-06 Pergolide mesylate salt
66104-23-2
US $1.00 / KG 1G 98% 100KG career henan chemical co

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