ALPHA-APO-OXYTETRACYCLINE
- CAS No.
- 18751-99-0
- Chemical Name:
- ALPHA-APO-OXYTETRACYCLINE
- Synonyms
- β-Apooxytetracycline;b-Apo-oxytetracycline;β-Apo-oxytetracycline;BETA-APO-OXYTETRACYCLINE;Apooxytetracycline, beta-;ALPHA-APO-OXYTETRACYCLINE;Oxytetracycline Impurity E;β-Apo-oxytetracycline, >85%;Oxytetracycline EP Impurity E;β-Apo-oxytetracycline, EvoPure?
- CBNumber:
- CB9455892
- Molecular Formula:
- C22H22N2O8
- Molecular Weight:
- 442.42
- MDL Number:
- MFCD00062827
- MOL File:
- 18751-99-0.mol
- MSDS File:
- SDS
| Melting point | 200-204 °C |
|---|---|
| Boiling point | 742.4±60.0 °C(Predicted) |
| Density | 1.62±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated) |
| form | Powder |
| pka | 1.62±0.58(Predicted) |
| color | Yellow-brown to brown |
| Stability | Unstable in basic solution |
| FDA UNII | 7HSY5812F9 |
| EPA Substance Registry System | 1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0) |
ALPHA-APO-OXYTETRACYCLINE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27099 | β-Apooxytetracycline | 18751-99-0 | 1mg | $76 | 2024-03-01 | Buy |
| Cayman Chemical | 27099 | β-Apooxytetracycline | 18751-99-0 | 10mg | $583 | 2024-03-01 | Buy |
| Cayman Chemical | 27099 | β-Apooxytetracycline | 18751-99-0 | 500μg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 27099 | β-Apooxytetracycline | 18751-99-0 | 5mg | $312 | 2024-03-01 | Buy |
| Usbiological | 002804 | β-Apo-oxytetracycline | 18751-99-0 | 1mg | $340 | 2021-12-16 | Buy |
ALPHA-APO-OXYTETRACYCLINE Chemical Properties,Uses,Production
Description
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.
Chemical Properties
yellow-brown to brown powder
Uses
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.
Uses
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability.
Uses
Oxytetracycline metabolite (absolute stereochemistry unknown)
ALPHA-APO-OXYTETRACYCLINE Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA-APO-OXYTETRACYCLINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| BEST-REAGENT | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11726 | 57 |
View Lastest Price from ALPHA-APO-OXYTETRACYCLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-29 | ALPHA-APO-OXYTETRACYCLINE USP/EP/BP
18751-99-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-26 | ALPHA-APO-OXYTETRACYCLINE
18751-99-0
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
-
- ALPHA-APO-OXYTETRACYCLINE USP/EP/BP
18751-99-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- ALPHA-APO-OXYTETRACYCLINE
18751-99-0
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co