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Cereblon Ligand 1

Cereblon Ligand 1 structure

CAS No.: 1061605-21-7

Chemical Name:: Cereblon Ligand 1

Synonyms: 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid;TC E3 5031;Thalidomide-O-COOH;Thalidomide-Acid;Cereblon Ligand 1;Cereblon ligand 3;Thalidomide-4-O-C1-COOH;Thalidomide-4-O-CH2-COOH;Thalidomide-4-hydroxyacetate;Pomalidomide Related Compound 1

CBNumber:: CB94666380

Molecular Formula:: C15H12N2O7

Molecular Weight:: 332.27

MDL Number:: MFCD31560477

MOL File:: 1061605-21-7.mol

Last updated:2024-07-02 08:55:42

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Cereblon Ligand 1 Properties

Boiling point	660.5±55.0 °C(Predicted)
Density	1.606±0.06 g/cm3(Predicted)
solubility	Soluble in DCM
form	A crystalline solid
pka	2.95±0.10(Predicted)
color	White to off-white
InChI	InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
InChIKey	ZVWIXIGBWIEDFO-UHFFFAOYSA-N
SMILES	C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

2933998090

NFPA 704

	0
2		0

Cereblon Ligand 1 price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21589	Cereblon Ligand 1 ≥98%	1061605-21-7	10mg	$81	2024-03-01	Buy
Cayman Chemical	21589	Cereblon Ligand 1 ≥98%	1061605-21-7	100mg	$475	2024-03-01	Buy
Tocris	6466	TCE35031 ≥98%(HPLC)	1061605-21-7	100	$439	2021-12-16	Buy
BroadPharm	BP-24447	Thalidomide-Acid 98%	1061605-21-7	250mg	$540	2021-12-16	Buy
BroadPharm	BP-24447	Thalidomide-Acid 98%	1061605-21-7	500mg	$890	2021-12-16	Buy

Product number	Packaging	Price	Buy
21589	10mg	$81	Buy
21589	100mg	$475	Buy
6466	100	$439	Buy
BP-24447	250mg	$540	Buy
BP-24447	500mg	$890	Buy

Cereblon Ligand 1 Chemical Properties,Uses,Production

Description

Thalidomide-Acid (Cereblon Ligand 1) is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.

Uses

Thalidomide-4-hydroxyacetate (Cereblon Ligand 1) is a proteolysis targeting chimeras which allows for the optical control of protein degradation.

Solubility in organics

DMF: 30 mg/ml
DMSO: 30 mg/ml
PBS (pH 7.2): 1 mg/ml

storage

Store at RT

Cereblon Ligand 1 Preparation Products And Raw materials

Raw materials

Preparation Products

Cereblon Ligand 1 Suppliers

Global( 95)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29888	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19536	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	4088	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	9205	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9316	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58

Supplier	Advantage
Shanghai finete Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Baoji Guokang Bio-Technology Co., Ltd.	58
BOC Sciences	58

View Lastest Price from Cereblon Ligand 1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Thalidomide-O-COOH 1061605-21-7	US $0.00-0.00 / mg	10mg	>95.00%	10g	Xian confluore Biological Technology Co., Ltd.
2022-09-24	Cereblon Ligand 1 1061605-21-7	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	Cereblon Ligand 1 1061605-21-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Thalidomide-O-COOH
1061605-21-7
US $0.00-0.00 / mg
>95.00%
Xian confluore Biological Technology Co., Ltd.

Cereblon Ligand 1
1061605-21-7
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Cereblon Ligand 1
1061605-21-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1061605-21-7(Cereblon Ligand 1)Related Search:

1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-PEG4-Propargyl Thalidomide-linker 10

Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc

tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20 4-Hydroxy ThalidoMide Protein degrader 1 (TFA)

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

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Cereblon Ligand 1 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid Cereblon ligand 3 Pomalidomide Related Compound 1 Thalidomide-Acid Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- 2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetic acid Thalidomide-4-hydroxyacetate 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid TC E3 5031 Thalidomide-O-COOH Thalidomide-O-COOH(Cereblon ligand 3) Eereblon Ligand 1/E3 ligase Ligand 3 Thalidomide-4-O-CH2-COOH inhibit,Ligands for E3 Ligase,ThalidomideOCOOH,Inhibitor,Thalidomide O COOH,Cereblon ligand3,E3 ligase-recruiting Moiety,Cereblon ligand-3 2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetic acid 2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]oxy]acetic Acid 2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid Thalidomide-4-O-C1-COOH 1061605-21-7 81061605-21-7