Anti-Prion Protein antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-Prion Protein antibody, Mouse monoclonal
- Synonyms
- Anti-Prion Protein antibody, Mouse monoclonal
- CBNumber:
- CB94669604
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-Prion Protein antibody, Mouse monoclonal price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P0110 | Anti-Prion Protein antibody, Mouse monoclonal clone 8H4, purified from hybridoma cell culture | 200μL | $607 | 2024-03-01 | Buy | |
Sigma-Aldrich | P0110 | Anti-Prion Protein antibody, Mouse monoclonal clone 8H4, purified from hybridoma cell culture | 25μL | $143 | 2022-05-15 | Buy |
Anti-Prion Protein antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-Prion Protein antibody, mouse monoclonal may be used in:
- immunoblotting
- flow cytometry
- immunocytochemistry
- immunoprecipitation
- immunoelectron microscopy
- immunohistochemistry
- enzyme linked immunosorbent assay
General Description
Anti-Prion Protein antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the hybridoma 8H4 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from Prnp-/- mice immunized with recombinant murine PrPc. Prion protein (PrP) is mapped to human chromosome 20p13. PrP is constitutively expressed in brain and other tissues of healthy humans and animals and is present in high levels at the synapse.
Biochem/physiol Actions
Prion-related diseases are fatal neurodegenerative disorders also known as transmissible spongiform encephalopathies (TSEs). Prion plaques are of three types: unicentric (single, compact core), multicentric (two or more cores and definite border), and diffuse plaques without a definite central core. Disease-associated prion protein specifically inhibits the proteolytic β-subunits of the 26S proteasome. This may clarify the mechanism of cell death by the prion protein. Prion protein may be involved in copper utilization, serving to buffer copper at the synaptic cleft or to mediate re-uptake of copper into the presynapse. Alternatively, bound copper may influence PrP binding characteristics. The PrP-copper complex may be crucial for synaptic homeostasis as a result of its antioxidant activity.
Anti-Prion Protein antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Prion Protein antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |