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PROTAMINE

PROTAMINE
PROTAMINE structure
CAS No.
9012-00-4
Chemical Name:
PROTAMINE
Synonyms
HSDB 3251;PROTAMINE;protamines;PROTAMINE USP/EP/BP;protamine from salmon;protamine free base grade iv
CBNumber:
CB9468351
Molecular Formula:
Formula Weight:
0
MOL File:
Mol file

PROTAMINE Properties

storage temp. 
-20°C
solubility 
H2O: clear
EWG's Food Scores
1
FDA UNII
72G3UY6T4N
ATC code
V03AB14
SAFETY
  • Risk and Safety Statements
WGK Germany  3
RTECS  UK9440000

PROTAMINE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P4005 Protamine from salmon Grade IV, Histone, free(Millon test) 9012-00-4 1g $258 2021-03-22 Buy
Sigma-Aldrich P4005 Protamine from salmon Grade IV, Histone, free(Millon test) 9012-00-4 5g $932 2021-03-22 Buy
Sigma-Aldrich P4005 Protamine from salmon Grade IV, Histone, free(Millon test) 9012-00-4 250mg $77.2 2021-03-22 Buy

PROTAMINE Chemical Properties,Uses,Production

Chemical Properties

Water soluble, producing basic solu- tions.

Definition

protamine: Any of a group of proteinsof relatively low molecularweight found in association with thechromosomal DNA of vertebratesperm cells. They contain a singlepolypeptide chain comprising about67% arginine. Protamines are thoughtto protect and support the chromosomes.

Definition

Simplest proteins, without sulfur, molecular weights about ~3000.

Mechanism of action

Protamine sulfate has been approved in the United States as a specific antagonist to heparin since 1968. Protamines are an arginine-rich, highly basic group of simple proteins derived from salmon sperm. The highly acidic heparin polysaccharides exhibit their anticoagulant activity through binding to antithrombin III. Because of the basicity of protamine, heparin has an increased affinity for protamine relative to antithrombin III. In fact, its binding affinity for protamine is so much greater than that of antithrombin III that protamine actually will induce dissociation of the heparin/antithrombin III complex. If protamine is administered in the absence of heparin, it can have marked effects on coagulation. Protamine is not completely selective for heparin and, in vivo, also interacts with fibrinogen, platelets, and other plasma proteins causing anticoagulation. For this reason, use of the minimal amount of protamine necessary to antagonize heparin-associated bleeding should be employed (usually 1 mg of protamine intravenously for every 100 U of heparin remaining in the patient).

Side effects

Anaphylaxis also has been associated with the use of protamine. Although development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protaminecontaining insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.

PROTAMINE Preparation Products And Raw materials

Raw materials

Preparation Products


PROTAMINE Suppliers

Global( 40)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Hubei Ipure Biology Co., Ltd
+8618062405514
18062427325 ada@ipurechemical.com;ada@ipurechemical.com China 10352 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9475 58
Shijiazhuang Tongyang Import and Export Co., LTD

admin@sjztongyang.com CHINA 995 58
BOC Sciences 16314854226
info@bocsci.com United States 21113 65
XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD. 86-029-85456576
86-029-85456576-808 daisy_wang@vip.163.com China 293 55
Wuhan Dahua Pharmaceutical Co., Ltd. 027-59262863 13277907145 QQ:3091977954
027-59420980 dh.luna@whdhwy.com China 4957 58
Hubei Jusheng Technology Co.,Ltd 18871490274 027-59599241-
027-59599241 1400878000@qq.com;1400868000@qq.com China 9841 58

View Lastest Price from PROTAMINE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-14 PROTAMINE
9012-00-4
1g 99 50ton Shijiazhuang tongyang Import and Export Co., LTD
2021-08-10 PROTAMINE
9012-00-4
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-08-06 PROTAMINE USP/EP/BP
9012-00-4
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

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