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Vincristine sulfate

Vincristine sulfate
Vincristine sulfate structure
Chemical Name:
Vincristine sulfate
VCR;oncovin;onkovin;nsc67574;NovopharM;Vincrisul;V5 PEPTIDE;lilly37231;vincristin;VCR SULFATE
Molecular Formula:
Formula Weight:
MOL File:

Vincristine sulfate Properties

Melting point:
300 °C
D26 +8.5° (c = 0.8)
Boiling point:
273-281 °C
storage temp. 
methanol: soluble20mg/mL
lyophilized powder
white to off-white
Water Solubility 
>=1 g/100 mL at 24 ºC
EWG's Food Scores
NCI Dictionary of Cancer Terms
Oncovin; vincristine sulfate
Proposition 65 List
Vincristine Sulfate
EPA Substance Registry System
Vincristine sulfate (2068-78-2)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H300-H341-H361fd-H360
Precautionary statements  P280-P264-P281-P301+P310-P201-P301+P310a-P308+P313-P405-P501a
Hazard Codes  T
Risk Statements  61-36/37/38-63-23/24/25-68-62-25
Safety Statements  22-24/25-53-45-37/39-26-36/37/39-36/37
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  OH6340000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29399990
Toxicity LD50 intraperitoneal in mouse: 3mg/kg

Vincristine sulfate price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1714007 Vincristine sulfate United States Pharmacopeia (USP) Reference Standard 2068-78-2 50mg $1080.45 2019-12-02 Buy
Sigma-Aldrich 1714018 Vincristine sulfate (assay) United States Pharmacopeia (USP) Reference Standard 2068-78-2 29.8mg $1080.45 2019-12-02 Buy
Alfa Aesar J60907 Vincristine sulfate 97+% 2068-78-2 10mg $147 2020-06-24 Buy
Alfa Aesar J60907 Vincristine sulfate 97+% 2068-78-2 25mg $293 2020-06-24 Buy
Cayman Chemical 11764 Vincristine (sulfate) ≥95% 2068-78-2 5mg $32 2020-06-24 Buy

Vincristine sulfate Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid


An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.




Vincristin sulfate USP (Oncovin) is used to treat acute leukemia in children; lymphocytic leukemia; Hodgkin’s disease; non-Hodgkin’s lymphomas; Wilm’s tumor; neuroblastoma; rhabdomyosarcoma.

brand name

Oncovin (Lilly); Vincasar (Sicor).

General Description

Vincristine sulfate is available as a 1-mg/mL solution in 1-,2-, and 5-mL vials for IV administration in acute leukemiaand as part of a multidrug regime for Hodgkin’s and neuroblastoma, Ewing sarcoma, Wilms tumor, soft tissuesarcoma, testicular cancer, liver cancer, and head and neckcancers. It has also been utilized in treating pediatric cancer.Vincristine is highly protein bound (75%) and may also bindto platelets that contain large amounts of tubulin. Numerousmetabolites have been detected and several have been identified,one of which is the 4-O-desacetyl derivative. The metabolismthat does occur is believed to largely be mediatedby CYP3A. Elimination occurs primarily in the bile with aterminal elimination half-life of 23 to 85 hours. The mostcommonly seen toxicity for vincristine is a dose-limitingneurotoxicity caused by effects on axonal microtubules.Symptoms are variable and include peripheral neuropathy,ataxia, seizure, bone pain, and coma. Constipation is also acommonly seen toxicity, and laxatives may be used prophylactically.Other toxicities include alopecia, skin rash, mildmyelosuppression, secretion of antidiuretic hormone,azospermia, and amenorrhea.

General Description

An anticancer drug. White to slightly yellow, amorphous or crystalline powder. Sensitive to light. Odorless. pH (0.1% solution) 3.5 - 4.5.

Air & Water Reactions

Very hygroscopic. Water soluble.

Reactivity Profile

Sensitive to hydrolysis, oxidation and heat. Incompatible with strong oxidizing agents. .

Fire Hazard

Flash point data for Vincristine sulfate are not available; however, Vincristine sulfate is probably combustible.

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Veterinary Drugs and Treatments

Vincristine is used as an antineoplastic primarily in combination drug protocols in dogs and cats in the treatment of lymphoid and hematopoietic neoplasms. In dogs, it may be used alone in the therapy of transmissible venereal neoplasms.
Because vincristine can induce thrombocytosis (at low doses) and has some immunosuppressant activity, it may also be employed in the treatment of immune-mediated thrombocytopenia.

Purification Methods

The salt is recrystallised from MeOH. It has UV max at 220, 255 and 296nm (log  4.65, 4.21 and 4.18). It is a monoamine oxidase inhibitor and is used in cancer research [Son et al. J Med Chem 33 1845 1990, Horio et al. Proc Natl Acad Sci USA 85 3580 1988].

Vincristine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

Vincristine sulfate Suppliers

Global( 340)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22625 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Hebei Chisure Biotechnology Co., Ltd.
0311 66567340 CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
Chengdu Greenpure Biopharma CO.,Ltd
18283602253 CHINA 1257 58
career henan chemical co
+86-371-86658258 CHINA 30043 58
Chengdu GLP Biotech Co., Ltd
13350802083 CHINA 1008 58
0086-13720134139 CHINA 968 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897 CHINA 2645 58

View Lastest Price from Vincristine sulfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-16 Vincristine Sulfate
US $0.00-0.00 / KG 1g 99% 50kg/month Beijing Yibai Biotechnology Co., Ltd
2019-07-05 Vincristine Sulfate
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-12-23 Vincristine sulfate
US $0.00 / mg 5mg ≥90%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.

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