ChemicalBook
Chinese Japanese Germany Korea

Altretamine

Altretamine
Altretamine structure
CAS No.
645-05-6
Chemical Name:
Altretamine
Synonyms
HTM;HMM;Hemel;NC 195;Hexalen;Hexylen;Hexastat;ent50852;nsc13875;ENT050852
CBNumber:
CB9480937
Molecular Formula:
C9H18N6
Formula Weight:
210.28
MOL File:
645-05-6.mol

Altretamine Properties

Melting point:
171-175 °C(lit.)
Boiling point:
339.81°C (rough estimate)
Density 
1.0441 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Refrigerator
pka
pKa 10.3 (Uncertain)
form 
solid
Water Solubility 
Insoluble
Merck 
13,318
CAS DataBase Reference
645-05-6(CAS DataBase Reference)
NIST Chemistry Reference
Altretamine(645-05-6)
EPA Substance Registry System
1,3,5-Triazine-2, 4,6-triamine, N,N,N',N',N'', N''-hexamethyl- (645-05-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P305+P351+P338-P261
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  OS1050000
HS Code  2933690000
Toxicity LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper)

Altretamine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 549835 2,4,6-Tris(dimethylamino)-1,3,5-triazine 96% 645-05-6 25g $329 2018-11-13 Buy
Sigma-Aldrich 1017105 Altretamine United States Pharmacopeia (USP) Reference Standard 645-05-6 500mg $352.8 2018-11-13 Buy
Cayman Chemical 23662 Altretamine ≥98% 645-05-6 50mg $35 2018-11-19 Buy
Cayman Chemical 23662 Altretamine ≥98% 645-05-6 100mg $63 2018-11-19 Buy
Cayman Chemical 23662 Altretamine ≥98% 645-05-6 250mg $88 2018-11-19 Buy

Altretamine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

antimalarial

Uses

As experimental insect chemosterilant.

Uses

An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.

Indications

Although both DNA and RNA synthesis are inhibited in cells exposed to hexamethylmelamine (Hexalen), the molecular mechanisms of these effects are not known.

Definition

A hexamethyl-2,4,6- triamine derivative of 1,3,5-triazine.

brand name

Hexalen (Millot Laboratories, France).

General Description

Altretamine is available in 50-mg capsules for oraladministration as a second-line treatment for ovarian cancer.The mechanism of action has not been firmly established, althoughthe spectrum of activity is similar to that for otheralkylating agents; however, cross-resistance is not seen.Cytotoxicity has been correlated with metabolism to give thecarbinolamines, which may form imines capable of crosslinking,or decompose to give formaldehyde, which may reactwith nucleophiles on DNA or proteins. The agent is well absorbedupon oral administration, well distributed, and highly(90%) plasma protein bound. The agent is extensively metabolizedin the liver by CYP to give demethylated metabolites via the previously mentioned carbinolamines. Elimination occursprimarily in the urine as mostly demethylated metaboliteswith a terminal elimination half-life of 4 to 10 hours.Myleosuppression and nausea/vomiting are dose-limitingtoxicities. Other adverse effects include lethargy, agitation,hallucinations, skin rash, and elevations in transaminase levels,flulike symptoms, abdominal cramps, and diarrhea.

General Description

Colorless crystalline solid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Altretamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic.

Mechanism of action

Hexamethylmelamine is readily absorbed after oral administration, with peak plasma levels achieved after 1 hour.The drug is readily metabolized to form a number of demethylated metabolites. Urinary elimination is the primary route of drug excretion.

Clinical Use

Hexamethylmelamine is useful for the treatment of ovarian adenocarcinoma and is frequently combined with cyclophosphamide, cisplatin, and doxorubicin in the treatment of this tumor. It also has some activity against small cell lung cancer.

Side effects

Nausea and vomiting are the major toxicities associated with hexamethylmelamine administration. Myelosuppression and a peripheral neuropathy also may occur.

Altretamine Preparation Products And Raw materials

Raw materials

Preparation Products


Altretamine Suppliers

Global( 126)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9920 62
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19977 64

View Lastest Price from Altretamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-25 Altretamine
645-05-6
US $8.00 / KG 1KG 99% 10tons career henan chemical co

645-05-6(Altretamine)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved