CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem
- CAS No.
- Chemical Name:
- CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem
- Synonyms
- CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem
- CBNumber:
- CB94816974
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem price More Price(1)
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable, bioavailable propenone compound that specifically targets TNF receptor-associated factor 6 (TRAF6; Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40. A six-week treatment of C57BL/6 mice fed high fat diet (HFD) with this compound show significant improvement in insulin sensitivity and hepatosteatosis without affecting HFD-induced weight gain. Also reported to reduce gonadal adipose tissue inflammation and diminish the number of CD11b+F4/80+CD11c+ M1 macrophages. Inhibits NF-κB activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (IC50 15.9 μM) and reduce IL-1β and IL-6 expression in anti-CD40 antibody FGK45-stimulated primary bone marrow-derived macrophages.
Biochem/physiol Actions
Cell permeable: yes
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem