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Methyl cyanoacetate

CAS No.
105-34-0
Chemical Name:
Methyl cyanoacetate
Synonyms
Methyl 2-cyanoacetate;2-cyanopropanoate;CYANOACETIC ACID METHYL ESTER;MCYA;usafkf-22;USAF kf-22;25KG,100KG,1T;Methylcyanacetat;METHYL CYANOACETATE;MetthylCyanoacetate
CBNumber:
CB9485583
Molecular Formula:
C4H5NO2
Lewis structure
c4h5no2 lewis structure
Molecular Weight:
99.09
MDL Number:
MFCD00001939
MOL File:
105-34-0.mol
MSDS File:
SDS
Last updated:2023-11-28 16:31:44

Methyl cyanoacetate Properties

Melting point -13 °C
Boiling point 204-207 °C(lit.)
Density 1.123 g/mL at 25 °C(lit.)
vapor density 3.41 (vs air)
vapor pressure 0.2 mm Hg ( 20 °C)
refractive index n20/D 1.417(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility 54g/l
form Liquid
pka 2.75±0.10(Predicted)
color Clear colorless to very slightly yellow
Water Solubility 54 g/L (20 ºC)
Sensitive Light Sensitive
BRN 773945
Dielectric constant 29.4(21℃)
LogP -0.47 at 25℃
CAS DataBase Reference 105-34-0(CAS DataBase Reference)
FDA UNII A28RI36V30
NIST Chemistry Reference Acetic acid, cyano-, methyl ester(105-34-0)
EPA Substance Registry System Acetic acid, cyano-, methyl ester (105-34-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  1
RTECS  AG4375000
Hazard Note  Irritant
TSCA  Yes
HS Code  29269095
Toxicity guinea pig,LDLo,skin,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 920, 1986.
NFPA 704
1
2 0

Methyl cyanoacetate price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 108421 Methyl cyanoacetate 99% 105-34-0 25g $57.4 2024-03-01 Buy
Sigma-Aldrich 108421 Methyl cyanoacetate 99% 105-34-0 2kg $209 2023-06-20 Buy
TCI Chemical C0442 Methyl Cyanoacetate >99.0%(GC) 105-34-0 25mL $34 2024-03-01 Buy
TCI Chemical C0442 Methyl Cyanoacetate >99.0%(GC) 105-34-0 500mL $75 2024-03-01 Buy
Alfa Aesar A15555 Methyl cyanoacetate, 99% 105-34-0 250g $43.2 2024-03-01 Buy
Product number Packaging Price Buy
108421 25g $57.4 Buy
108421 2kg $209 Buy
C0442 25mL $34 Buy
C0442 500mL $75 Buy
A15555 250g $43.2 Buy

Methyl cyanoacetate Chemical Properties,Uses,Production

Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Chemical Properties

clear colorless to very slighlty yellow liquid

Uses

pharmaceutical intermediate

Uses

Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Definition

ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester.

General Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Kn?venagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters.

Purification Methods

Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]

Global( 506)Suppliers
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View Lastest Price from Methyl cyanoacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl cyanoacetate pictures 2024-03-29 Methyl cyanoacetate
105-34-0
US $0.00 / KG 1KG 99.5% 500mt/year Jinan Finer Chemical Co., Ltd
Methyl cyanoacetate pictures 2023-08-16 Methyl cyanoacetate
105-34-0
US $1.00 / KG 1KG >99% 3000T Weijer International Trade (Hebei) Co., Ltd
Methyl Cyanoacetate pictures 2023-03-06 Methyl Cyanoacetate
105-34-0
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
Methyl cyanoethanoate methyl2-cyanoacetate methylcyanoethanoate Methylester kyseliny kyanoctove methylesterkyselinykyanoctove USAF kf-22 usafkf-22 Aceticacid,cyano-,methylester cyano-aceticacimethylester Malonic methyl ester nitrile Malonicacidmononitrilemethylester Methylcyanacetat METHYL CYANOACETATE MCYA MALONIC ACID METHYL ESTER NITRILE MetthylCyanoacetate (Methoxycarbonyl)acetonitrile Methyl cyanoacetate,97% Methyl cyanoacetate, 97% 250ML Methyl cyanoacetate, 99.5% 3-Methoxy-3-oxopropanenitrile, Methyl 2-cyanoethanoate Methyl cyanoacetate 99% 3-Methoxy-3-oxopropanenitrile Tofacitinib Impurity 198 Pemetrexed disodium Impurity 12 25KG,100KG,1T Acetic acid, 2-cyano-, methyl ester Methyl Cyanoacetate > Methyl cyanoacetate, 99%, for synthesis Milrinone Impurity 25 (Methyl cyanoacetate) Methyl cyanoacetate ISO 9001:2015 REACH Milrinone Impurities7 Methyl cyanoacetate intermediate Methyl 2-cyanoacetate CYANOACETIC ACID METHYL ESTER 2-cyanopropanoate 105-34-0 105-35-7 NCCH2CO2CH3 NCCH2COOCH3 ISOCYANATE Carbonyl Compounds C2 to C5 Building Blocks Organic Building Blocks Esters organic chemical Piperazines C2 to C5 Carbonyl Compounds Esters