GUANABENZ ACETATE
- CAS No.
- 23256-50-0
- Chemical Name:
- GUANABENZ ACETATE
- Synonyms
- br750;Wytens;WY-8678;FLA-137;Tenelid;Wytensin;Wy 8678 acetate;GUANABENZ ACETATE;GuanabenzAcetate>GUANABENZACETATE,USP
- CBNumber:
- CB9491023
- Molecular Formula:
- C10H12Cl2N4O2
- Molecular Weight:
- 291.13
- MDL Number:
- MFCD00153801
- MOL File:
- 23256-50-0.mol
| Melting point | 227-229℃ (decomposition) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: 11 mg/mL |
| form | solid |
| color | white |
| Merck | 14,4558 |
| Stability | Hygroscopic |
| FDA UNII | 443O19GK1A |
| NCI Drug Dictionary | guanabenz acetate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | MF0382000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2928002500 |
GUANABENZ ACETATE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1301404 | Guanabenz acetate United States Pharmacopeia (USP) Reference Standard | 23256-50-0 | 200mg | $250 | 2024-03-01 | Buy |
| Sigma-Aldrich | 370625 | Guanabenz Acetate - CAS 23256-50-0 - Calbiochem A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator. | 23256-50-0 | 250mg | $219 | 2023-06-20 | Buy |
| TCI Chemical | G0456 | Guanabenz Acetate >98.0%(HPLC)(T) | 23256-50-0 | 200mg | $34 | 2024-03-01 | Buy |
| TCI Chemical | G0456 | Guanabenz Acetate >98.0%(HPLC)(T) | 23256-50-0 | 1g | $99 | 2024-03-01 | Buy |
| Sigma-Aldrich | G110 | Guanabenz acetate salt powder | 23256-50-0 | 25mg | $64.4 | 2024-03-01 | Buy |
GUANABENZ ACETATE Chemical Properties,Uses,Production
Uses
antihypertensive
Uses
α2-adrenergic agonist and IGRS selective ligand
Definition
ChEBI: Guanabenz acetate is a dichlorobenzene. It has a role as a geroprotector.
brand name
Wytensin (Wyeth).
General Description
Guanabenz acetate, [(2,6-dichlorobenzylidene)amino]guanidine monoacetate (Wytensin), is acentral 2-adrenergic agonist that reduces the release of norepinephrinefrom the neuron when stimulated. The effect ofthe drug results in decreased sympathetic tone in the heart,kidneys, and peripheral blood vessels. The drug does not produceorthostatic hypotension.
Biological Activity
α 2 -adrenergic agonist and IGRS (imidazoline I 2 binding site) selective ligand.
Biochem/physiol Actions
Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.
Pharmacokinetics
The oral bioavailability of guanabenz is 70 to 80%. Following an oral dose, the hypotensive effect of guanabenz begins
within 1 hour, peaks within 2 to 7 hours, and is diminished within 6 to 8 hours. It has an elimination half-life averaging
4 to 14 hours. The blood pressure response can persist for at least 12 hours. Following IV dosing, guanabenz is
distributed into the CNS, with brain concentrations 3 to 70 times higher than concurrent plasma concentrations.
Guanabenz is approximately 90% bound to plasma proteins. In patients with hepatic or renal impairment, its elimination
half-life may be prolonged.
Guanabenz is metabolized principally by hydroxylation to its inactive metabolite, 4-hydroxyguanabenz, which is
eliminated in the urine as its glucuronide (major) and sulfate conjugates. Guanabenz and its inactive
metabolites are excreted principally in urine, with approximately 70 to 80% of its oral dose excreted in urine within 24
hours and approximately 10–30% in feces via enterohepatic cycling. Approximately 40% of an oral dose of guanabenz
is excreted in urine as 4-hydroxyguanabenz and its glucuronide, and less than 5% is excreted unchanged. The
remainder is excreted as unidentified metabolites and their conjugates.
Clinical Use
Overall, the therapeutic applications for guanabenz are similar to those of clonidine and other α2-adrenergic agonists. One advantage for guanabenz is its once-a-day dosing schedule. Guanabenz has been used in diabetic patients with hypertension without adverse effect on the control of or therapy for diabetes, and it has been effective in hypertensive patients with chronic obstructive pulmonary disease, including asthma, chronic bronchitis, or emphysema. Guanabenz has been used alone or in combination with naltrexone in the management of opiate withdrawal in patients physically dependent on opiates and undergoing detoxification. Guanabenz also has been used as an analgesic in a limited number of patients with chronic pain
Side effects
Overall, the frequency of adverse effects produced by guanabenz is similar to that produced by clonidine and the other α2-adrenergic agonists, but the incidence is lower. As with the other centrally active sympatholytics (e.g., clonidine), abrupt withdrawal of guanabenz may result in rebound hypertension, but the withdrawal syndrome symptoms appear to be less severe.
storage
Store at RT
GUANABENZ ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1206 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9604 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29525 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from GUANABENZ ACETATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | GUANABENZ ACETATE USP/EP/BP
23256-50-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-07-13 | Guanabenz Acetate
23256-50-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Guanabenz Acetate
23256-50-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- GUANABENZ ACETATE USP/EP/BP
23256-50-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Guanabenz Acetate
23256-50-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Guanabenz Acetate
23256-50-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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